High altitude pulmonary edema
MONDO:0031257A rare pulmonary condition characterized by non-cardiogenic pulmonary edema occurring in otherwise healthy individuals within days of an ascent above 2500-3000 m. Early symptoms include exertional dyspnea, non-productive cough, chest tightness, and reduced exercise performance, followed by dyspnea at rest and possibly orthopnea, as well as gurgling in the chest and pink frothy sputum in advanced cases. Clinical signs are cyanosis, tachypnea, tachycardia, crackles or wheezing, and elevated body temperature (generally not exceeding 38.5°C). Signs of concomitant high-altitude cerebral edema may also be observed. Chest x-rays typically show patchy opacities predominantly in the right middle lobe.
38 clinical trials for this condition and its sub-types, 5 tagged with High altitude pulmonary edema itself.
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One-Size-Fits-All oxygen may be outdated: new trial tests personalized targets
Disease control By invitation onlyThis study is testing whether giving each patient on a ventilator a personalized oxygen target (based on their unique health data) leads to better outcomes than standard care. Researchers will compare death rates and time spent on the ventilator between the two groups. The trial …
Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Ultrasound peek at diaphragm could guide breathing support
Knowledge-focused OngoingThis study observes how the diaphragm works in 100 adults with acute respiratory failure who need non-invasive breathing support or high-flow oxygen. Researchers use ultrasound to measure diaphragm movement and thickness at different support levels. The goal is to understand how …
Sponsor: Foro Internacional en Cuidado Crítico • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC