Head and neck neoplasm
MONDO:0005586A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.
Also known as: craniocervical region neoplasm, craniocervical region neoplasm (disease), craniocervical region tumor, craniocervical region tumour, head and neck neoplasm, head and neck neoplasm (excluding central nervous system), head and neck tumor, head and neck tumour
3510 clinical trials for this condition and its sub-types, 79 tagged with Head and neck neoplasm itself.
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Sub-types of Head and neck neoplasm
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Head and neck cancer 637 trials · 2,004 incl. sub-types
16 sub-types
- Head and neck carcinoma 73 trials · 1,415 incl. sub-types Sub-types →
- Malignant tumor of neck 14 trials · 505 incl. sub-types Sub-types →
- Ocular cancer 10 trials · 168 incl. sub-types Sub-types →
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Skull cancer 0 trials · 38 incl. sub-types Sub-types →
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Nasal cavity cancer 5 trials · 14 incl. sub-types Sub-types →
- Malignant cranial nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Malignant ear neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Angiosarcoma of the scalp 0 trials
- Malignant carotid body paraganglioma 0 trials
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Neoplasm of neck 1 trial · 505 incl. sub-types
4 sub-types
- Malignant tumor of neck 14 trials · 505 incl. sub-types Sub-types →
- Benign neoplasm of neck 0 trials
- Cervical dermoid cyst 0 trials
- Cervical neuroblastoma 0 trials
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Neoplasm of oropharynx 3 trials · 279 incl. sub-types
2 sub-types
- Oropharynx cancer 149 trials · 279 incl. sub-types Sub-types →
- Benign neoplasm of oropharynx 0 trials
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Nasopharyngeal neoplasm 37 trials · 226 incl. sub-types
3 sub-types
- Malignant tumor of nasopharynx 9 trials · 213 incl. sub-types Sub-types →
- Benign neoplasm of nasopharynx 0 trials
- Nasopharyngeal teratoma 0 trials
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Eye neoplasm 3 trials · 192 incl. sub-types
13 sub-types
- Ocular cancer 10 trials · 168 incl. sub-types Sub-types →
- Uvea neoplasm 1 trial · 103 incl. sub-types Sub-types →
- Retina neoplasm 2 trials · 36 incl. sub-types Sub-types →
- Conjunctival tumor 1 trial · 23 incl. sub-types Sub-types →
- Benign neoplasm of eye 0 trials · 19 incl. sub-types Sub-types →
- Cornea neoplasm 0 trials · 17 incl. sub-types Sub-types →
- Eyelid neoplasm 3 trials · 7 incl. sub-types Sub-types →
- Intraocular medulloepithelioma 1 trial
- Ocular surface squamous neoplasia 1 trial
- Combined hamartoma of the retina and retinal pigment epithelium 0 trials
- Lacrimal gland neoplasm 0 trials Sub-types →
- Orbital leiomyoma 0 trials
- Ring dermoid of cornea 0 trials
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Skull neoplasm 0 trials · 161 incl. sub-types
7 sub-types
- Skull base neoplasm 12 trials · 124 incl. sub-types Sub-types →
- Skull cancer 0 trials · 38 incl. sub-types Sub-types →
- Paranasal sinus neoplasm 5 trials · 29 incl. sub-types Sub-types →
- Neoplasm of jaw 1 trial · 9 incl. sub-types Sub-types →
- Orbit neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Jugular foramen meningioma 0 trials
- Schwannoma of jugular foramen 0 trials
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Neoplasm of hypopharynx 0 trials · 100 incl. sub-types
3 sub-types
- Hypopharynx cancer 50 trials · 100 incl. sub-types Sub-types →
- Benign neoplasm of hypopharynx 0 trials Sub-types →
- Epiglottis neoplasm 0 trials Sub-types →
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Tumor of salivary gland 9 trials · 85 incl. sub-types
4 sub-types
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Neoplasm of major salivary gland 0 trials · 17 incl. sub-types Sub-types →
- Benign neoplasm of salivary gland 1 trial · 5 incl. sub-types Sub-types →
- Neoplasm of minor salivary gland 0 trials Sub-types →
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Nasal cavity and paranasal sinus neoplasm 0 trials · 44 incl. sub-types
1 sub-type
- Nasal cavity and paranasal sinus carcinoma 21 trials · 44 incl. sub-types Sub-types →
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Tongue neoplasm 2 trials · 35 incl. sub-types
2 sub-types
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Benign neoplasm of tongue 0 trials
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Lip neoplasm 1 trial · 15 incl. sub-types
2 sub-types
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Benign neoplasm of lip 0 trials
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Nasal cavity neoplasm 1 trial · 15 incl. sub-types
3 sub-types
- Nasal cavity cancer 5 trials · 14 incl. sub-types Sub-types →
- Benign neoplasm of nasal cavity 1 trial Sub-types →
- Nasal cavity inverting papilloma 0 trials
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Benign epithelial tumor of salivary glands 0 trials · 12 incl. sub-types
1 sub-type
- Pleomorphic adenoma 12 trials
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Recurrent respiratory papillomatosis 8 trials · 9 incl. sub-types
1 sub-type
- Laryngeal papillomatosis 1 trial
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Cranial nerve neoplasm 0 trials · 8 incl. sub-types
12 sub-types
- Malignant cranial nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Abducens nerve neoplasm 0 trials
- Facial nerve neoplasm 0 trials
- Glossopharyngeal nerve neoplasm 0 trials Sub-types →
- Hypoglossal nerve neoplasm 0 trials Sub-types →
- Oculomotor nerve neoplasm 0 trials Sub-types →
- Spinal accessory nerve neoplasm 0 trials
- Trigeminal nerve neoplasm 0 trials Sub-types →
- Trochlear nerve neoplasm 0 trials
- Vestibulocochlear nerve neoplasm 0 trials Sub-types →
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Tonsil neoplasm 0 trials · 8 incl. sub-types
2 sub-types
- Tonsil cancer 5 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of tonsil 0 trials Sub-types →
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Odontogenic neoplasm 0 trials · 5 incl. sub-types
4 sub-types
- Keratocystic odontogenic tumor 3 trials
- Ameloblastoma 2 trials Sub-types →
- Ameloblastic carcinoma 0 trials
- Calcifying epithelial odontogenic tumor 0 trials
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Ocular adnexal lymphoma 4 trials
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Malignant epithelial tumor of salivary glands 0 trials · 4 incl. sub-types
1 sub-type
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Ear neoplasm 0 trials · 3 incl. sub-types
5 sub-types
- Malignant ear neoplasm 0 trials · 2 incl. sub-types Sub-types →
- External ear neoplasm 0 trials · 1 incl. sub-types Sub-types →
- Inner ear neoplasm 0 trials · 1 incl. sub-types Sub-types →
- Neoplasm of middle ear 0 trials · 1 incl. sub-types Sub-types →
- Benign neoplasm of ear 0 trials Sub-types →
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Familial thyroglossal duct cyst 2 trials
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Buccal mucosa neoplasm 0 trials · 2 incl. sub-types
2 sub-types
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of buccal mucosa 0 trials Sub-types →
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Gingival neoplasm 0 trials · 2 incl. sub-types
3 sub-types
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of gum 0 trials Sub-types →
- Congenital epulis 0 trials
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Neoplasm of floor of mouth 0 trials · 2 incl. sub-types
2 sub-types
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Benign neoplasm of floor of mouth 0 trials
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Palatal neoplasm 0 trials · 2 incl. sub-types
4 sub-types
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Soft palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Benign neoplasm of hard palate 0 trials
- Benign neoplasm of soft palate 0 trials
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Head and neck paraganglioma 1 trial
4 sub-types
- Carotid body paraganglioma 0 trials Sub-types →
- Jugulotympanic paraganglioma 0 trials Sub-types →
- Tympanic paraganglioma 0 trials
- Vagus nerve paraganglioma 0 trials
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Cavernous hemangioma of face 0 trials
1 sub-type
- Cavernous hemangioma of retina 0 trials
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Epignathus 0 trials
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Facial dermoid cyst 0 trials
2 sub-types
- Nasal dermoid cyst 0 trials
- Orbital dermoid cyst 0 trials
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Gasserian ganglion meningioma 0 trials
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Laryngeal neuroendocrine neoplasm 0 trials
1 sub-type
- Laryngeal small cell carcinoma 0 trials
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Laryngotracheal angioma 0 trials
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Lipoma of face 0 trials
1 sub-type
- Lipoma of the conjunctiva 0 trials
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Nasal ganglioglioma 0 trials
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Nasal glial heterotopia 0 trials
Most studied deeper sub-types
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New combo injection targets Hard-to-Treat head and neck tumors
Disease control Recruiting nowThis early-phase trial is testing a new approach for people with head and neck cancer that has returned or spread after standard chemotherapy. The treatment combines a gene therapy injection (EDS01) given directly into a tumor with an immunotherapy drug (toripalimab) given throug…
Phase 1 • Sponsor: West China Hospital • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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New hope for frail seniors with head and neck cancer: easier treatment regimen tested
Disease control Recruiting nowThis study tests a milder combination of chemotherapy, immunotherapy, and radiation for adults aged 65 and older with head and neck cancer who are considered frail. The goal is to see if more patients can complete the full treatment course. The regimen is tailored based on a biom…
Phase 3 • Sponsor: Brown University • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Could less radiation be enough for head and neck cancer?
Disease control Recruiting nowThis study tests whether giving lower doses of radiation to certain head and neck cancer patients can still effectively treat the cancer while causing fewer side effects. Participants receive chemotherapy and radiation, and doctors use a special PET scan to decide who can get the…
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New enzyme shot takes aim at Hard-to-Treat tumors
Disease control Recruiting nowThis trial tests a new drug called N17350, a modified enzyme injected directly into tumors, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find the safest and most effective dose, and to see if the drug can shrink or stop tu…
Phase 1/2 • Sponsor: Onchilles Pharma Inc • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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New hope for head and neck cancer: drug may prevent recurrence after chemoradiation
Disease control Recruiting nowThis study tests whether the drug dostarlimab, given after standard chemoradiation, can help prevent head and neck cancer from coming back or spreading. About 864 adults with advanced but not surgically removable head and neck cancer will receive either dostarlimab or a placebo. …
Phase 3 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Blood test guides chemo timing in head and neck cancer trial
Disease control Recruiting nowThis phase 2 study tests whether adding occasional chemotherapy to the immunotherapy drug pembrolizumab (Keytruda) can improve outcomes for people with recurrent or metastatic head and neck cancer. A blood test that measures tumor DNA helps doctors decide when to give the chemo. …
Phase 2 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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New combo aims to shrink radiation damage in head and neck cancer
Disease control Recruiting nowThis study tests two ideas at once: adding a drug called ATRA (Vesanoid) to standard treatment, and using a smaller radiation area that targets the tumor more precisely. It includes 460 adults with certain types of head and neck cancer that haven't spread across the midline. The …
Phase 3 • Sponsor: Centre Leon Berard • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New cocktail of cancer drugs targets Hard-to-Treat head and neck tumors
Disease control Recruiting nowThis early-stage trial is testing a new three-drug combination for people with head and neck cancer that has come back or spread. The drugs include a targeted therapy (zanzalintinib), an immunotherapy (pembrolizumab), and another targeted antibody (cetuximab). The main goal is to…
Phase 1 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Gene test could make chemo safer by tailoring doses
Disease control Recruiting nowThis study tests whether adjusting the dose of chemotherapy drugs (fluorouracil or capecitabine) based on a person's DPYD gene test can lower the risk of severe side effects. About 100 cancer patients with a specific gene variant will receive either a reduced starting dose or sta…
Phase 4 • Sponsor: Rutgers, The State University of New Jersey • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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One drop, many cancers? a rapid test aims to spot cancer signals in blood, urine, or saliva
Diagnosis Recruiting nowThis study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …
Sponsor: Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo • Aim: Diagnosis
Last updated Aug 05, 2026 00:00 UTC
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New imaging tool helps doctors see brain tumors more clearly
Diagnosis Expanded accessThis program offers a special PET scan using a radioactive tracer called methionine to help doctors better see and manage central nervous system (brain, spine) and head/neck tumors in children and young adults. The scan provides extra information that can guide treatment decision…
Sponsor: St. Jude Children's Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 12:23 UTC
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Can a frankincense cream shield skin from radiation burns?
Prevention Recruiting nowThis trial tests whether a cream made from Boswellia serrata (Indian olibanum) gum resin can prevent the painful skin irritation that often occurs during radiation therapy for head and neck cancer. Adults with head and neck cancer scheduled for radiation will apply the 2% cream t…
Sponsor: Youssef Hashem Hafez • Aim: Prevention
Last updated Aug 23, 2026 00:00 UTC
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Common pain gel could shield cancer patients from radiation burns
Prevention Recruiting nowThis study tests whether a gel containing diclofenac, a common anti-inflammatory drug, can prevent severe skin irritation caused by radiation therapy. About 156 adults with head/neck or breast cancer will apply the gel or a placebo to the treated skin three times daily during the…
Sponsor: The Second Affiliated Hospital of Hainan Medical University • Aim: Prevention
Last updated Jun 27, 2026 12:03 UTC
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Light therapy app aims to ease dry mouth for cancer survivors
Symptom relief Recruiting nowThis study tests whether a special light therapy (photobiomodulation) combined with a mobile health app can improve dry mouth and quality of life in people who have had head and neck cancer and completed radiation. Sixty participants will receive either real light therapy or a sh…
Sponsor: Universidad de Granada • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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Can tai chi ease the exhaustion of cancer radiotherapy?
Symptom relief Recruiting nowResearchers are testing whether a 12-week Tai Chi program can reduce cancer-related fatigue in people with head and neck cancer who are receiving radiotherapy. The trial enrolls 116 adults who do not exercise regularly. Half join a supervised Yang-style 16-form Tai Chi group alon…
Sponsor: West China Hospital • Aim: Symptom relief
Last updated Sep 17, 2026 00:00 UTC
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New radiation method aims to save swallowing in cancer patients
Symptom relief Recruiting nowThis study tests a new way to give radiation to people with head and neck cancer. The goal is to see if protecting the parts of the throat used for swallowing can help patients eat and drink better after treatment. About 136 adults with certain types of head and neck cancer will …
Phase 3 • Sponsor: All India Institute of Medical Sciences • Aim: Symptom relief
Last updated Sep 13, 2026 00:00 UTC
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Touch and tingle: Non-Drug therapies aim to tame chemo side effects
Symptom relief Recruiting nowThis study tests whether foot reflexology or a mild electrical nerve stimulation on the ear can reduce pain, dry mouth, fatigue, and sleep problems in people with head and neck cancer who are receiving chemoradiotherapy. Participants are randomly assigned to receive the real trea…
Sponsor: Tzu Chi University • Aim: Symptom relief
Last updated Jul 26, 2026 00:00 UTC
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New tool aims to ease the journey for head and neck cancer survivors and caregivers
Symptom relief Recruiting nowThis study tests a program called SNAP that helps head and neck cancer survivors and their caregivers after radiation treatment. The program includes a needs assessment, a personalized care plan, and a mobile app. Researchers want to see if it reduces symptoms for survivors and e…
Sponsor: Medical University of South Carolina • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Daily exercise may ease radiation side effects for head and neck cancer patients
Symptom relief Recruiting nowThis study tests whether a daily physical activity routine, started before and continued during radiotherapy, can improve physical function and quality of life for head and neck cancer patients. 80 patients with tumors of the oropharynx, larynx, or hypopharynx will be randomly as…
Sponsor: Sahlgrenska University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Extra care days after cancer surgery may ease anxiety
Symptom relief Recruiting nowThis study looks at whether adding three extra support visits after surgery can lower anxiety and improve quality of life for people with head and neck cancers. About 60 patients will take part. The goal is to see if more follow-up care helps patients cope better after their oper…
Sponsor: Clinique Pasteur Lanroze • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Could ozone gas soothe cancer Patients' painful mouth sores?
Symptom relief Recruiting nowThis study tests whether applying medical ozone gas to mouth sores can reduce pain and severity in people undergoing radiation or chemotherapy for head and neck cancer. Fifty participants will receive ozone therapy, and half will also use a special toothpaste and mouthwash at hom…
Sponsor: University of Pavia • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Can acupuncture tame Radiation's harsh side effects?
Symptom relief Recruiting nowThis study is testing whether acupuncture can help reduce the painful side effects of radiation therapy in people with head and neck cancer. Sixty participants will receive either acupuncture plus standard care or standard care alone. The goal is to see if acupuncture can lower t…
Sponsor: Masaryk Memorial Cancer Institute • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Can a tiny doppler turn blood flow sounds into pictures to save rebuilt tissue?
Knowledge-focused Recruiting nowResearchers at Mayo Clinic are studying whether an implantable Doppler monitor can record the sound of blood flowing through a free flap and convert it into a visual signal. The trial enrolls 100 adults scheduled for free flap surgery, a procedure that moves tissue to rebuild par…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Sep 21, 2026 13:00 UTC
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Scientists launch massive tissue collection to unlock secrets of head and neck diseases
Knowledge-focused Recruiting nowThis study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover surgical tissue and additional samples like blood, saliva, and cheek swabs to study the…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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Simple test for throat cancer on the horizon?
Knowledge-focused Recruiting nowThis study from Mayo Clinic aims to find biological markers (biomarkers) in blood, tissue, and saliva that can signal the presence or absence of HPV-related oropharyngeal cancer. Researchers will follow 560 participants, including patients with and without the disease, to see if …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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New imaging study aims to sharpen radiotherapy for head and neck cancer
Knowledge-focused Recruiting nowThis study is testing whether advanced PET/MR imaging can help doctors personalize radiotherapy for head and neck cancer. Researchers will scan 390 patients before, during, and after treatment to see if imaging details can predict survival and response. The goal is to improve out…
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Scientists hunt for genetic clues in head and neck cancers
Knowledge-focused Recruiting nowThis study looks at the genetic makeup of head and neck tumors from 1,000 people to find markers that predict how well a patient will respond to treatment and their chances of survival. Researchers will also search for new diagnostic markers. The goal is to better understand why …
Sponsor: Montefiore Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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8,000-Patient study aims to sharpen cancer radiation with Real-Time MRI
Knowledge-focused Recruiting nowThis study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…
Sponsor: UMC Utrecht • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Blood test could predict cancer return after surgery
Knowledge-focused Recruiting nowThis study looks at a blood test that measures tiny bits of tumor DNA floating in the blood. Researchers will enroll 50 adults with head and neck cancer who are planning surgery. They want to see how these DNA levels change after surgery and whether they can help predict if the c…
Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Scientists launch massive biobank to unlock secrets of hearing, smell, and voice disorders
Knowledge-focused Recruiting nowThis study collects leftover tissue samples and additional blood, saliva, and cheek swabs from up to 1,000 people with hearing, balance, smell, taste, voice, or speech disorders. The samples are stored in a biobank for researchers to study the biology of these conditions. No new …
Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD) • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC