Gingivitis

This study looks at whether a toothpaste with a special gum-health ingredient can improve gum health in people with gingivitis. 150 adults will use the test toothpaste for 13 weeks, then switch to a regular fluoride toothpaste for 4 weeks. Researchers will measure gum inflammatio…

This study tests whether a special wipe containing xylitol, a natural sweetener, can reduce dangerous bloodstream infections in children and young adults undergoing stem cell transplants. These infections often start from bacteria in the mouth and can be life-threatening. Partici…

This trial tests whether applying a gel containing hyaluronic acid and chlorhexidine after a minimally invasive deep cleaning can improve gum healing in people with advanced periodontitis (stage III or IV). Participants receive either the deep cleaning alone or the cleaning plus …

This study tests whether a toothpaste with stannous fluoride works better than regular fluoride toothpaste at reducing dental plaque and gum inflammation (gingivitis). About 85 adults with mild to moderate gum disease will brush twice daily for 6 months. Dentists will measure pla…

This study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…

This study in Malawi tests whether chewing xylitol gum three times a day during pregnancy can improve gum health and change the bacteria in the mouth and vagina. Researchers will also check if it reduces pregnancy complications and affects babies' brain development. 80 pregnant w…

This study tests whether motivational interviewing, a supportive counseling method, can help teenagers aged 14-19 with braces improve their oral hygiene. Participants receive short, non-judgmental conversations to set their own goals for brushing and flossing. The goal is to redu…

This study tests whether brushing with stannous fluoride toothpaste twice a day for three months reduces gum bleeding and inflammation better than a standard fluoride toothpaste. 120 adults with mild to moderate gingivitis will be randomly assigned to one of three toothpastes. Th…

This trial tests whether an artificial intelligence model can accurately diagnose gingivitis — early gum disease — by analyzing digital photographs and X-rays. Researchers will compare the AI's assessments to those of dental experts. If it works, this approach could make gum dise…

This study is testing whether artificial intelligence (AI) can accurately diagnose periodontitis (severe gum disease) and monitor gum inflammation using dental records and X-rays. Researchers will develop and validate AI models using data from 900 patients across multiple hospita…

This study tests whether a topical 10% povidone-iodine solution can prevent white spot lesions on the front teeth of teens undergoing fixed orthodontic treatment. Healthy participants aged 10 to 17 will receive either the iodine solution or a placebo applied to all tooth surfaces…

This study tested two ways to teach people with gingivitis (early gum disease) how to clean their teeth better. One group watched a video, the other practiced on a dental model. After one month, both groups showed improved gum health and awareness, with no major difference betwee…

This study tests a numbing method called intraseptal anesthesia for gum surgery. Sixty adults with gum disease will receive a small amount of articaine to see if it effectively blocks pain during the procedure. The goal is to find a less painful alternative to standard numbing te…

This study tested how well different home oral hygiene devices (like interdental brushes and picks) reduce plaque and gum bleeding in 40 adults with gingivitis. Participants used the tools at home and were checked monthly. The goal was to see which device works best for everyday …

This study looks at whether sonic electric toothbrushes or manual toothbrushes are better at reducing gum inflammation in pregnant women. Gum problems are common during pregnancy due to hormone changes. The trial will follow 120 pregnant women aged 18-40 to see which toothbrush t…

This observational study measures three proteins, PTHrP, RANKL, and OPG, in the fluid that seeps from the gums. Researchers will compare levels in 81 adults split into three groups: healthy gums, gingivitis, and periodontitis. During a routine dental exam, they collect fluid samp…

This study explores whether a health app and follow-up digital meetings can motivate teenagers to improve their oral hygiene. Researchers will interview 25 adolescents aged 16-17 who have gum disease (gingivitis) to see if the app helps them build better brushing habits. The goal…

This study looks at how smoking changes the body's immune response in gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link between smoking and infl…

This study looks at how metal and ceramic braces change the bacteria in dental plaque (biofilm) and affect gum health in 80 people with crooked teeth. Researchers will measure the types and amounts of bacteria, plaque buildup, and gum swelling. The goal is to understand how diffe…