Erythromelalgia
MONDO:0016028A rare neurovascular peripheral pain disorder due to the intermittent blockage of the blood vessels, usually in the lower extremities or hands. This causes hyperemia and inflammation at the origin of burning pain and skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia may occur either as a primary or secondary disorder. Primary erythromelalgia is caused by gene mutations. Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, essential thrombocytemia, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders.
15 clinical trials for this condition and its sub-types, 3 tagged with Erythromelalgia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Erythromelalgia
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Primary erythermalgia 8 trials
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Secondary erythromelalgia 0 trials
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Fingertip wrinkle test may spot nerve damage
Diagnosis CompletedThis study looked at whether a 15-minute hand soak in warm water can help diagnose small fiber neuropathy, a condition that causes pain, numbness, and problems with automatic body functions. Researchers tested 38 adults and compared the wrinkling pattern of their fingertips to st…
Sponsor: HOSPITAL BRITANICO DE BUENOS AIRES • Aim: Diagnosis
Last updated Jun 27, 2026 08:02 UTC
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Can a home tablet catch wound infections before they send patients back to the hospital?
Prevention CompletedResearchers are testing whether a home telehealth system can prevent complications after vascular surgery that involves a groin incision. Patients scheduled for these procedures are randomly assigned to receive either standard discharge instructions or a tablet with a weight scal…
Sponsor: CAMC Health System • Aim: Prevention
Last updated Sep 11, 2026 00:00 UTC
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Could hidden nerve damage explain pain in kids with developmental delays?
Knowledge-focused CompletedThis completed study looked at whether children with neurodevelopmental disorders (like mitochondrial disease, cerebral palsy, or developmental delay) have fewer small nerve fibers in their skin, which could cause pain. Researchers took small skin biopsies from 203 children—some …
Sponsor: Heinrich-Heine University, Duesseldorf • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC