Erectile dysfunction
MONDO:0005362Persistent or recurrent inability to achieve or to maintain an erection during sexual activity.
Also known as: erectile dysfunction, erectile dysfunction (disease), male erectile Disorder, sexual impotence (finding), dysfunction, erectile, impotence, impotence, male, impotence, male sexual
126 clinical trials for this condition and its sub-types, 121 tagged with Erectile dysfunction itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Erectile dysfunction
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Vasculogenic impotence 9 trials
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Priapism 4 trials
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New registry to monitor penile implant success in 450 men
Disease control By invitation onlyThis study is a registry that collects real-world information on the safety and effectiveness of Boston Scientific penile implants for erectile dysfunction. It will enroll 450 men who are already scheduled to receive the implant. Researchers will track changes in erectile functio…
Sponsor: Boston Scientific Corporation • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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AI-Crafted supplement aims to restore testosterone naturally
Disease control By invitation onlyThis trial tests whether a daily nutritional supplement, designed with artificial intelligence to target gut bacteria, can increase testosterone production in men aged 30-65 with functional secondary hypogonadism—a condition where the body doesn't make enough testosterone despite…
Sponsor: Varol TUNALI • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Could a single rinse replace antibiotic cocktails in penile implant surgery?
Disease control OngoingThis study compares two methods to prevent infections during first-time penile implant surgery for erectile dysfunction. One group receives the standard antibiotic rinse, the other uses Irrisept, a simpler cleaning solution. Researchers will follow 200 men for one year after surg…
Phase 3 • Sponsor: Rush University Medical Center • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Could a placental wrap help men recover erections faster after prostate cancer surgery?
Disease control OngoingThis trial tests whether placing a dehydrated human amnion chorion membrane (dHACM) over the nerves during robot-assisted prostate removal helps men recover erectile function and urinary control sooner. The study enrolls men aged 40 to 80 with localized prostate cancer who have g…
Phase 2 • Sponsor: University of Miami • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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Could stem cells restore erectile function? new trial tests the idea
Disease control OngoingThis study tests whether stem cells from a patient's own bone marrow or fat can improve erectile dysfunction better than platelet-rich plasma or standard treatments. One hundred men with organic ED who did not respond to pills will receive one of these therapies. The goal is to s…
Phase 2 • Sponsor: National Scientific Medical Center, Kazakhstan • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Can a few extra pills prevent implant infections?
Disease control OngoingThis study looks at whether taking oral antibiotics for 6 extra days after getting a penile implant can lower the chance of infection. Researchers are following 800 men for one year after surgery. The goal is to see if this simple step reduces the need for another surgery to remo…
Early phase 1 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Could a blood injection treat erectile dysfunction? new trial investigates
Disease control By invitation onlyThis study compares platelet-rich plasma (PRP) injections to the standard drug alprostadil (Caverject) for treating moderate to severe erectile dysfunction. Sixty men will receive both treatments in a crossover design, with each treatment given as six weekly injections. The main …
Sponsor: Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Could a tiny nerve zap restore erectile function?
Symptom relief OngoingThis study tests whether low-dose electrical stimulation of the pudendal nerve can improve erectile function in men with mild to moderate erectile dysfunction. Twenty-four men will receive a 20-minute stimulation session, and researchers will measure changes in erection hardness,…
Sponsor: Camilo Jose Cela University • Aim: Symptom relief
Last updated Jul 31, 2026 00:00 UTC
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Could a simple nerve zap treat erectile dysfunction?
Symptom relief OngoingThis study tests whether stimulating the pudendal nerve with a small electrical current can improve erections in men with erectile dysfunction. 72 men aged 18-60 will receive either real stimulation or a sham procedure. Researchers will measure changes in erectile function, hardn…
Sponsor: Camilo Jose Cela University • Aim: Symptom relief
Last updated Jul 31, 2026 00:00 UTC
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Fenugreek extract put to the test as a natural remedy for erectile dysfunction
Symptom relief OngoingThis phase 3 trial is testing whether Testofen, a standardized fenugreek extract, can improve erectile function in healthy men aged 40 to 75 with mild to moderate erectile dysfunction. Participants take either 300 mg or 600 mg of Testofen or a placebo daily for 12 weeks. The stud…
Phase 3 • Sponsor: RDC Clinical Pty Ltd • Aim: Symptom relief
Last updated Jul 29, 2026 00:00 UTC
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New home device aims to treat erectile dysfunction without drugs
Symptom relief OngoingThis study tests a device called VERTICA® that uses radio frequency energy to treat erectile dysfunction (ED). About 98 men with mild to moderate ED will use the device at home for 6 months, either the real device or a sham version. The goal is to see if the device improves erect…
Sponsor: OHH-MED Medical Ltd • Aim: Symptom relief
Last updated Jul 25, 2026 00:00 UTC
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Liquid vs tablet: which sildenafil form do men prefer?
Symptom relief OngoingThis study looks at whether men with mild-to-moderate erectile dysfunction are more satisfied with sildenafil in a liquid suspension form compared to tablets that dissolve in the mouth. Researchers will review records of men who took each form for three months. The goal is to see…
Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico • Aim: Symptom relief
Last updated Jul 04, 2026 00:00 UTC
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Nerve-Sparing radiation may help men keep sexual function after prostate cancer treatment
Symptom relief OngoingThis phase 2 trial is testing whether a special type of radiation therapy (SAbR) that avoids the nerves involved in erections can help preserve sexual function in men with localized prostate cancer. About 124 men will be randomly assigned to receive standard SAbR or a version tha…
Phase 2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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New combo therapy aims to boost erections without drugs
Symptom relief OngoingThis study tests whether combining platelet-rich plasma (PRP) injections with shock wave therapy can improve erections in men with moderate erectile dysfunction. 116 men will receive either the real treatment or a placebo over 9 weeks, then be followed for 6 months. The goal is t…
Sponsor: Elexial Research Limited • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Prostate Surgery's hidden toll: study probes lasting impact on Men's lives
Knowledge-focused By invitation onlyThis study looks at men who had their prostate removed for cancer at least one year ago. Researchers want to understand how common and severe problems like urine leakage and erectile dysfunction are, and how these issues affect quality of life, self-esteem, and relationships. Par…
Sponsor: University of Valencia • Aim: Knowledge-focused
Last updated Jul 15, 2026 00:00 UTC
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Large registry launched to measure penile implant success
Knowledge-focused OngoingThis study is a registry that collects information from over 1000 men who have surgery to get a penile implant for erectile dysfunction. The main goal is to measure how satisfied patients and their partners are after the procedure. The study does not test a new treatment, but rat…
Sponsor: European Association of Urology Research Foundation • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Depression's hidden toll on male sexual function revealed
Knowledge-focused OngoingThis study looks at how the severity of depression relates to erectile dysfunction and premature ejaculation in 100 married men aged 25–60 in the Sohag region of Egypt. Participants are clinically diagnosed with depression and sexually active. Researchers will use standard questi…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Holistic education study for stress withdrawn before starting
Knowledge-focused CancelledThis study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …
Sponsor: Goddess Zena I. Jones • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Scientists investigate link between blood fats and sickle cell crises
Knowledge-focused OngoingThis study looks at how different types of fats in the blood (like cholesterol) are linked to complications in adults with sickle cell disease. Researchers will follow 116 participants from the French Caribbean islands to track their fat levels over time and during acute events l…
Sponsor: Centre Hospitalier Universitaire de la Guadeloupe • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC