Epidermal disease
MONDO:0019268A skin disease that involves the epidermis.
Also known as: epidermal disease, rare epidermal disease
131 clinical trials for this condition and its sub-types, 0 tagged with Epidermal disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Epidermal disease
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Ichthyosis 13 trials · 41 incl. sub-types
3 sub-types
- Inherited ichthyosis 6 trials · 33 incl. sub-types Sub-types →
- Acquired ichthyosis 0 trials
- Ichthyosis, follicular 0 trials
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Inherited epidermolysis bullosa 5 trials · 38 incl. sub-types
4 sub-types
- Epidermolysis bullosa dystrophica 23 trials · 30 incl. sub-types Sub-types →
- Junctional epidermolysis bullosa 6 trials · 8 incl. sub-types Sub-types →
- Epidermolysis bullosa simplex 6 trials Sub-types →
- Kindler syndrome 0 trials Sub-types →
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Palmoplantar pustulosis 22 trials
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Hereditary palmoplantar keratoderma 0 trials · 13 incl. sub-types
8 sub-types
- Diffuse palmoplantar keratoderma 0 trials · 12 incl. sub-types Sub-types →
- Olmsted syndrome 1 trial Sub-types →
- Focal palmoplantar keratoderma 0 trials · 1 incl. sub-types Sub-types →
- Palmoplantar keratoderma, epidermolytic 0 trials · 1 incl. sub-types Sub-types →
- Alopecia congenita keratosis palmoplantaris 0 trials
- Palmoplantar keratoderma i, striate, focal, or diffuse 0 trials
- Palmoplantar keratoderma, nonepidermolytic, focal or diffuse 0 trials
- Punctate palmoplantar keratoderma 0 trials Sub-types →
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Erythrokeratoderma 0 trials · 12 incl. sub-types
6 sub-types
- Pityriasis rubra pilaris 2 trials · 12 incl. sub-types Sub-types →
- MEDNIK syndrome 0 trials
- Cardiomyopathy, dilated, with wooly hair, keratoderma, and tooth agenesis 0 trials
- Erythrokeratoderma en cocardes 0 trials
- Erythrokeratodermia variabilis 0 trials Sub-types →
- Spinocerebellar ataxia type 34 0 trials
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Hailey-Hailey disease 4 trials
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Keratosis pilaris atrophicans 2 trials
4 sub-types
- Atrophoderma vermiculata 0 trials
- Keratosis follicularis spinulosa decalvans 0 trials Sub-types →
- Keratosis pilaris atrophicans faciei 0 trials
- Ulerythema ophryogenesis 0 trials
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Darier disease 1 trial
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Hereditary poikiloderma 1 trial
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13q12.3 microdeletion syndrome 0 trials
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Hyperkeratosis lenticularis perstans 0 trials
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Keratolytic winter erythema 0 trials
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2 sub-types
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Phrynoderma 0 trials
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Porokeratosis 0 trials
4 sub-types
- Disseminated superficial actinic porokeratosis 0 trials Sub-types →
- Linear porokeratosis 0 trials
- Porokeratosis of Mibelli 0 trials Sub-types →
- Porokeratosis plantaris palmaris et disseminata 0 trials
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Psoriasis 14, pustular 0 trials
Most studied deeper sub-types
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Experimental drug for rare skin disease fails to reach goal
Disease control Stopped earlyThis early-stage trial tested a drug called DS-2325a in 9 adults with Netherton syndrome, a rare genetic condition causing severe skin redness, scaling, and allergies. The study aimed to check safety and whether the drug could help control the disease. However, the trial was term…
Phase 1/2 • Sponsor: Daiichi Sankyo • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Promising drug for hand and foot blisters falls short in early trial
Disease control Stopped earlyThis study tested a daily pill called deucravacitinib in 3 adults with palmoplantar pustulosis (PPP), a painful skin condition causing blisters on palms and soles. The goal was to see if the drug could reduce disease severity by at least 50% over 24 weeks. However, the trial was …
Phase 4 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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New drug hope for painful hand and foot pustules
Disease control Stopped earlyThis trial tested the drug deucravacitinib in people with moderate-to-severe palmoplantar pustulosis, a skin condition causing painful pustules on the palms and soles. The study planned to enroll 25 participants who would take the drug daily for 16 weeks, but it was terminated ea…
Sponsor: Peking University First Hospital • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Hope for rare skin disease: new drug shows promise in trial
Disease control Stopped earlyThis study tested a medicine called spesolimab for people with Netherton syndrome, a rare genetic skin condition causing severe redness and scaling. About 43 people aged 12 and older took part, receiving either the drug or a placebo. The goal was to see if spesolimab could reduce…
Phase 2/3 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Spesolimab shows promise for Long-Term control of painful hand and foot pustules
Disease control Stopped earlyThis study looks at the long-term safety of spesolimab for people with palmoplantar pustulosis, a chronic skin condition causing painful pustules on hands and feet. Participants who benefited from spesolimab in earlier trials can continue treatment for up to 5 years, with monthly…
Phase 2 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Promising ichthyosis drug trial stalls after just 5 patients
Disease control Stopped earlyThis study tested a drug called imsidolimab (ANB019) in people with ichthyosis, a condition that causes dry, scaly, and red skin. The trial aimed to see if the drug could improve skin symptoms compared to a placebo. However, the study was stopped early and only enrolled 5 partici…
Phase 2 • Sponsor: Vanda Pharmaceuticals • Aim: Disease control
Last updated Jun 26, 2026 17:50 UTC
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Can an eczema drug calm a rare genetic skin disease?
Symptom relief Stopped earlyNetherton syndrome is a rare genetic disorder that causes red, scaly, inflamed skin and intense itching. No targeted treatments exist, so researchers are testing dupilumab, an injectable drug already used for eczema, against a placebo in 10 adults with moderate to severe Netherto…
Phase 2/3 • Sponsor: University Hospital, Toulouse • Aim: Symptom relief
Last updated Sep 21, 2026 14:00 UTC
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Can a blood injection boost carpal tunnel surgery results?
Symptom relief Stopped earlyThis study looked at whether adding platelet-rich plasma (PRP) to standard carpal tunnel release surgery helps people with severe carpal tunnel syndrome. The trial planned to enroll 15 adults with severe nerve damage. It compared surgery with PRP to surgery alone. The study was t…
Sponsor: Michael Fredericson, MD • Aim: Symptom relief
Last updated Jun 27, 2026 12:26 UTC
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Psoriasis drug trial for sensitive areas halted early
Symptom relief Stopped earlyThis study tested the drug deucravacitinib (SOTYKTU) in 130 people with psoriasis on the palms, soles, and genitals. The goal was to see if it improves skin clearance and reduces symptoms. The trial was terminated early, so final results are limited.
Phase 4 • Sponsor: Bristol-Myers Squibb • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Rare skin disease study seeks to understand netherton syndrome
Knowledge-focused Stopped earlyThis study aimed to collect real-world data on Netherton Syndrome, a rare genetic skin disorder. Researchers planned to follow 4 participants over 52 weeks, measuring skin severity and other symptoms. The study was terminated early, so results are limited.
Sponsor: Boehringer Ingelheim • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC