Dysplasia of cervix

This phase 1 trial tests a DNA vaccine designed to target HPV16, a virus that can cause high-grade cervical lesions (CIN2/3). The vaccine is given by injection into the muscle followed by a mild electrical pulse to help cells take up the DNA. The study includes both HIV-negative …

This phase 2 trial tests a DNA vaccine called PVX4 in 138 women with HPV16-related high-grade cervical dysplasia (CIN2/3). The vaccine is given as a shot with a small electrical pulse to help it enter cells. The goal is to see if it can clear the virus and make abnormal cervical …

This study in El Salvador tests a new thermal ablation device (IRIS™) to treat cervical precancer and an AI algorithm to help decide who needs treatment. About 5,000 HPV-positive women aged 30-49 will receive the treatment and be followed for one year to see if the precancer is c…

This early-stage trial tests whether a mushroom-based vaginal gel (Papilocare) can help clear HPV and reverse mild to moderate cervical dysplasia (CIN1/CIN2). Seventy women aged 30-50 will either use the gel for 6 months or follow the standard 'watch and wait' approach. The study…

This early-phase study is testing whether fenofibrate, a drug normally used to lower cholesterol, can help treat HPV-related cervical cancer and high-grade cervical dysplasia. Researchers will give the drug to 24 adults before their planned surgery and then examine tissue samples…

This study tests a supplement called Papillex® to see if it can help reverse abnormal cervical cells caused by HPV. Researchers will compare Papillex® to a placebo in 60 women with mild to moderate cervical changes (CIN 1 or 2). Participants take the supplement daily for 180 days…

This study tests whether a vaginal suppository called Dysplasix can help women clear high-risk human papillomavirus (HPV) and reverse low-grade cervical abnormalities. About 45 women with HPV and mild cervical changes will use the suppository or a placebo for 19 days. Researchers…

This phase II trial is testing whether the immunotherapy drug pembrolizumab (Keytruda) can treat high-grade cervical precancer (CIN 2/3 or carcinoma in situ). The study will enroll 25 women and measure how many have a complete response at 6 months. The goal is to see if this drug…

This phase II trial tests whether artesunate, a drug originally used for malaria, can reverse cervical pre-cancer (CIN2/3) when given as a vaginal insert. About 78 women with high-grade cervical lesions will receive either artesunate or a placebo for three 5-day cycles. The main …

This study aims to develop a screening test that uses a vaginal swab and blood sample to find DNA markers for endometrial, ovarian, and cervical cancers. Researchers at Mayo Clinic will enroll over 3,000 women to see if the test can accurately detect these cancers at an early sta…

This study is testing whether giving women a simple self-sampling kit to use at home can increase the number of women who get screened for cervical cancer. The trial will enroll 15,000 women in Czech Republic, especially those who haven't had a Pap smear in over 3 years. Particip…

This study compares the standard Pap smear with a new blood test that looks for three proteins to detect early cervical changes and cancer. About 558 women aged 18-85 will participate. The goal is to see if the blood test is as good or better at finding problems early.

This study is testing a new, low-cost screening tool for cervical cancer that uses artificial intelligence to analyze digital images of the cervix. It does not require a lab and can be used at the point of care. The goal is to see if this AI tool can accurately detect precancerou…

This study is testing a blood test called NavDx that looks for tiny pieces of HPV DNA shed by cancer cells. The goal is to see if this simple blood draw can accurately detect cervical cancer and precancer, and monitor how patients respond to treatment. The study will enroll 100 w…

This study compares three different surgical methods for removing abnormal cervical tissue (conization) to see which one causes the least heat-related damage. The goal is to improve the accuracy of lab analysis after surgery. 150 women needing this procedure will take part, and p…

This study is testing whether liquid biopsies (blood tests that look for bits of HPV and tumor DNA) can help doctors monitor treatment and spot early signs of cancer returning in people with HPV-related cervical and oropharyngeal cancers. Researchers will follow 480 participants …

This study explores whether a simple at-home HPV test can help women in war-torn Ukraine get screened for cervical cancer. About 1,000 women aged 30-60 who haven't had a recent negative HPV test will receive a self-sampling kit. The goal is to see if this approach is practical an…