Diabetic kidney disease

This trial compares three approaches for treating painful diabetic neuropathy: oral medications, topical treatments, and cognitive behavioral therapy. Researchers will enroll 600 adults with diabetes and nerve pain, randomly assigning them to one of these options for four months.…

This study tests two drugs, finerenone and empagliflozin, in 30 African American veterans with diabetic kidney disease. The goal is to see if these drugs reduce kidney cell damage by measuring specific proteins in urine. Participants will take one or both drugs for 4 months to ch…

This trial is testing whether adding two newer medications—finerenone and mazdutide—to a standard two-drug regimen can better protect the kidneys in people with type 2 diabetes and early kidney disease. About 820 adults will be randomly assigned to one of four treatment groups, a…

This trial tests whether infusions of stem cells from human umbilical cord blood can safely help people with type 2 diabetic nephropathy, a serious kidney complication of diabetes. Participants receive multiple intravenous infusions of these stem cells alongside their standard ca…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This study tests whether an oral medication that removes lead from the body can slow kidney function decline in people with type 2 diabetes and high lead levels. Participants take dimercaptosuccinic acid (DMSA) capsules for up to 3 months, then are followed for 12 months. The goa…

This study tests whether a drug that removes lead from the blood can slow the worsening of kidney function in people with type 2 diabetes who also have higher-than-normal lead levels. Participants receive intravenous infusions of calcium disodium edetate, and their kidney functio…

This study tests a smart computer system that helps primary care doctors screen for and manage diabetic kidney disease in adults with type 2 diabetes. The tool automatically calculates kidney function, reminds doctors to order urine tests, and gives personalized treatment advice.…

This trial investigates whether adding Naoxintong Capsule, a traditional Chinese medicine made from 16 herbal and animal ingredients, to standard therapy can slow the progression of diabetic nephropathy in people with type 2 diabetes. The study involves 410 participants who will …

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This pilot study will test whether adding a traditional Chinese herbal formula (DKD-1) to standard care can improve kidney function in people with diabetic kidney disease. Sixty-six adults with type 2 diabetes and moderate-to-severe chronic kidney disease will be randomly assigne…

This study compares a two-drug combination (dapagliflozin plus finerenone) against dapagliflozin alone in 88 adults with type 2 diabetes and chronic kidney disease. The goal is to see if the combo better reduces protein in urine, a key sign of kidney damage. Participants take pil…

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study tests a Traditional Chinese Medicine (TCM) herbal formula, Jiajian Yishen Xiaozheng Qufeng Granules, combined with AI-driven diagnostics to treat diabetic nephropathy (kidney disease from type 2 diabetes). About 198 adults with mild-to-moderate kidney damage will recei…

This early-stage study tests whether injecting human umbilical cord stem cells can prevent narrowing of the arm vein used for dialysis in people with end-stage diabetic kidney disease. About 54 participants will receive the stem cell treatment after fistula surgery. The goal is t…

This study tests whether the drug finerenone can slow kidney function decline and lower heart failure risk in 120 adults with type 2 diabetes and chronic kidney disease. Participants must already be on standard blood pressure medications. The study will measure changes in kidney …

This early-stage trial tests whether a single intravenous infusion of stem cells from donated umbilical cord tissue can safely improve kidney function in 32 adults with stage 3 or 4 chronic kidney disease caused by diabetes or high blood pressure. Participants will be randomly as…

This phase 2 trial tests whether combining dapagliflozin (a diabetes drug) with SC0062 (a blood vessel drug) can better protect kidneys in adults with type 1 diabetes and chronic kidney disease. Thirty-six participants will try each treatment alone and together in a cross-over de…

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

This study looks at whether routine blood test markers—like the Systemic Immune-Inflammation Index and platelet ratios—can help identify diabetic kidney disease in people with type 2 diabetes. Researchers will compare these markers across patients with different levels of albumin…

This study looks at whether measuring a hormone called irisin in the blood can help find diabetic kidney disease early and track how it gets worse. Researchers will compare irisin levels in 200 adults with type 2 diabetes to healthy people. The goal is to see if irisin can be a s…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study looks at whether two blood markers—DEL-1, an anti-inflammatory protein, and thromboxane A2, a sign of platelet activity—are linked to diabetic nephropathy, a common kidney complication of diabetes. Researchers will measure these markers in 80 adults, including patients…

This study investigates whether psychological well-being and social support influence how well people with diabetic kidney disease manage their own health. Adults with type 2 diabetes and diabetic kidney disease who are not on dialysis will fill out questionnaires about their emo…

This study follows 425 adults with type 2 diabetes and chronic kidney disease who are taking finerenone, a standard medication. Researchers collect blood and urine samples over four months to look for biomarkers that predict whether the drug helps reduce kidney damage. The goal i…

This study will check if a specific cholesterol ratio (non-HDL to HDL) is linked to kidney disease in people with diabetes. Researchers will measure this ratio and kidney function in 84 adults. The goal is to better understand risk factors, not to test a new treatment.

This study looks at 270 adults with diabetic kidney disease to see if gut bacteria and blood chemicals influence blood sugar swings and disease progression. Researchers will track participants over time using continuous glucose monitors and stool/blood samples. The goal is to fin…

This observational study will follow 200 hospitalized adults with chronic kidney disease to see how diabetes and related metabolic problems affect their outcomes. Researchers will track deaths, need for dialysis, and major heart events during the hospital stay. The goal is to bet…

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This study will use advanced MRI scans and blood tests to explore how SGLT2i medications protect the kidneys in 100 people with diabetic kidney disease who are at risk of worsening. Participants will already be taking SGLT2i as part of their routine care. The goal is to identify …

This study will check if certain blood markers—like MCP-1, NLR, and hsCRP—can help detect kidney disease early in people with type 2 diabetes. Researchers will measure these markers in 80 adults and compare them to standard kidney tests. The goal is to find a simpler way to ident…