Demyelinating disease
MONDO:0002562A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase traveling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others.
Also known as: demyelinating disorder
931 clinical trials for this condition and its sub-types, 27 tagged with Demyelinating disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Demyelinating disease
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Demyelinating disease of central nervous system 4 trials · 860 incl. sub-types
2 sub-types
- Multiple sclerosis 765 trials · 852 incl. sub-types Sub-types →
- Myelin oligodendrocyte glycoprotein antibody-associated disease 22 trials Sub-types →
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Polyradiculoneuropathy 1 trial · 64 incl. sub-types
4 sub-types
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Demyelinating polyneuropathy 2 trials · 62 incl. sub-types
2 sub-types
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Acute disseminated encephalomyelitis 7 trials · 8 incl. sub-types
3 sub-types
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Central pontine myelinolysis 2 trials
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Balo concentric sclerosis 0 trials
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Schilder disease 0 trials
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Boylan dew greco syndrome 0 trials
Most studied deeper sub-types
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Can a quick strike drug stop MS in its tracks?
Disease control Recruiting nowThis study tests whether giving the drug natalizumab (Tyruko) within two weeks of first MS symptoms can help repair nerve damage. Forty adults with a first episode of MS-like inflammation will receive either the drug or a placebo. The main goal is to see if early treatment improv…
Phase 2 • Sponsor: Queen Mary University of London • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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A new brain scan tracer aims to light up myelin damage
Diagnosis Recruiting nowResearchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…
Phase 1 • Sponsor: Yale University • Aim: Diagnosis
Last updated Sep 11, 2026 00:00 UTC
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Strumming for the brain: could ukulele lessons sharpen minds in MS?
Symptom relief Recruiting nowThis study tests whether a 12-week online ukulele learning program, called Music-4-MS, can improve cognitive function in people with multiple sclerosis (MS). Half the participants will learn to play the ukulele, while the other half will simply listen to music they enjoy. The goa…
Sponsor: University of Texas at Austin • Aim: Symptom relief
Last updated Aug 19, 2026 00:00 UTC
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Can a questionnaire reveal the hidden burden of a rare genetic disease in women?
Knowledge-focused Recruiting nowThis study looks at women who carry the gene for X-linked adrenoleukodystrophy (X-ALD), a rare inherited condition that mainly affects the nervous system. Although the disease is linked to the X chromosome, up to 80% of female carriers may develop symptoms like leg weakness and b…
Sponsor: Leipzig University Medical Center • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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New MRI technique may sharpen diagnosis of multiple sclerosis in older adults
Knowledge-focused Recruiting nowThis study is testing whether an advanced MRI technique called Quantitative Susceptibility Mapping (QSM) can better tell apart brain lesions caused by multiple sclerosis (MS) from those due to normal aging or small vessel disease. Researchers will scan 1,000 people aged 50-70 wit…
Sponsor: Oslo University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:01 UTC
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New registry aims to unlock secrets of rare diseases
Knowledge-focused Recruiting nowThis study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …
Sponsor: Hospital Italiano de Buenos Aires • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC