Craniosynostosis
MONDO:0015469Craniosynostosis is defined as the premature fusion of one or more cranial sutures leading to secondary distortion of skull shape resulting in skull deformities with a variable presentation. Craniosynostosis may occur in an isolated setting or as part of a syndrome.
Also known as: craniosynostosis syndrome, premature closure of cranial sutures, CSO
39 clinical trials for this condition and its sub-types, 17 tagged with Craniosynostosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Craniosynostosis
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Syndromic craniosynostosis 1 trial · 22 incl. sub-types
40 sub-types
- Acrocephalosyndactyly 0 trials · 13 incl. sub-types Sub-types →
- Crouzon syndrome-acanthosis nigricans syndrome 4 trials
- Antley-Bixler syndrome 2 trials Sub-types →
- Muenke syndrome 2 trials
- Crouzon syndrome 1 trial Sub-types →
- Shprintzen-Goldberg syndrome 1 trial
- Pseudoaminopterin syndrome 1 trial
- Baller-Gerold syndrome 0 trials
- Beare-Stevenson cutis gyrata syndrome 0 trials
- C syndrome 0 trials
- Curry-Jones syndrome 0 trials
- Hunter-McAlpine craniosynostosis 0 trials
- Lowry-MacLean syndrome 0 trials
- Summitt syndrome 0 trials
- TCF12-related craniosynostosis 0 trials
- Weiss-Kruszka syndrome 0 trials
- X-linked intellectual disability-plagiocephaly syndrome 0 trials
- Acrocephalopolydactyly 0 trials
- Autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome 0 trials
- Cardiocranial syndrome, Pfeiffer type 0 trials
- Cloverleaf skull-asphyxiating thoracic dysplasia syndrome 0 trials
- Cloverleaf skull-multiple congenital anomalies syndrome 0 trials
- Cranioectodermal dysplasia 0 trials Sub-types →
- Craniomicromelic syndrome 0 trials
- Craniosynostosis 2 0 trials
- Craniosynostosis 4 0 trials
- Craniosynostosis and dental anomalies 0 trials
- Craniosynostosis, Herrmann-Opitz type 0 trials
- Craniosynostosis, Philadelphia type 0 trials
- Craniosynostosis-anal anomalies-porokeratosis syndrome 0 trials
- Craniosynostosis-cataract syndrome 0 trials
- Craniosynostosis-fibular aplasia syndrome 0 trials
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome 0 trials
- Craniosynostosis-intracranial calcifications syndrome 0 trials
- Craniotelencephalic dysplasia 0 trials
- Familial scaphocephaly syndrome 0 trials Sub-types →
- Holoprosencephaly-craniosynostosis syndrome 0 trials
- Lethal occipital encephalocele-skeletal dysplasia syndrome 0 trials
- Osteosclerosis-developmental delay-craniosynostosis syndrome 0 trials
- Trigonocephaly-broad thumbs syndrome 0 trials
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Isolated craniosynostosis 1 trial · 3 incl. sub-types
4 sub-types
- Isolated oxycephaly 0 trials · 2 incl. sub-types Sub-types →
- Isolated cloverleaf skull syndrome 0 trials
- Isolated trigonocephaly 0 trials Sub-types →
- Non-syndromic unisutural craniosynostosis 0 trials
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Craniosynostosis syndrome, autosomal recessive 0 trials · 2 incl. sub-types
2 sub-types
- Antley-Bixler syndrome 2 trials Sub-types →
- Cranioectodermal dysplasia 0 trials Sub-types →
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Iida Kannari syndrome 0 trials
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Craniosynostosis Fontaine type 0 trials
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Craniosynostosis autosomal dominant 0 trials
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Craniosynostosis contractures cleft 0 trials
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Craniosynostosis with ectopia lentis 0 trials
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Craniosynostosis, Adelaide type 0 trials
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Mehta lewis patton syndrome 0 trials
Most studied deeper sub-types
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Smart sensors in baby helmets could revolutionize flat head treatment
Disease control CompletedThis study tests a custom helmet fitted with temperature and pressure sensors to monitor how long and how well it is worn by infants being treated for flat head syndrome (plagiocephaly or brachycephaly). The goal is to see if the sensors can accurately track wear time and detect …
Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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New drug combo targets tough breast cancer in early trial
Disease control CompletedThis early-phase study tests a new drug called E7090, alone or with other cancer medicines, in people with a common type of advanced breast cancer (ER+, HER2-). The main goal is to find safe doses and understand side effects. About 51 participants will take part to guide future r…
Phase 1 • Sponsor: Eisai Co., Ltd. • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Could your own blood seal a brain leak better than glue?
Disease control CompletedThis study tested whether membranes made from a patient's own blood (L-PRF) can seal the skull base after sinus surgery as well as standard fibrin glues. 220 adults with sellar lesions were randomly assigned to receive either L-PRF or commercial sealants. The main goal was to com…
Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Targeted drug shows promise for rare bile duct cancer
Disease control CompletedThis study tested an experimental drug called E7090 in 63 people with advanced bile duct cancer that has a specific genetic change (FGFR2 fusion). Participants had already tried chemotherapy without success. The goal was to see if the drug could shrink tumors. Results help determ…
Phase 2 • Sponsor: Eisai Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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Gentle hands, round heads: osteopathy may stop baby skull flattening
Prevention CompletedThis study tested whether early osteopathic treatment in newborns with risk factors (like a preferred head turn or muscle tightness) could prevent positional skull deformities (flat head). 101 babies were randomly assigned to receive either osteopathic sessions plus standard advi…
Sponsor: University Hospital, Montpellier • Aim: Prevention
Last updated Jun 27, 2026 07:53 UTC
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New MRI scan could replace painful kidney biopsies for transplant patients
Knowledge-focused CompletedThis study tested a special MRI technique called magnetic resonance elastography (MRE) to see if it can detect scarring in transplanted kidneys. Researchers compared MRE results with traditional biopsy samples from 73 kidney transplant patients. The goal was to find a non-invasiv…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Gene study seeks clues to Longer-Lasting kidney transplants
Knowledge-focused CompletedThis study looked at whether certain gene variations affect how well a transplanted kidney works over time. Researchers checked 80 kidney transplant recipients for specific gene markers and measured their kidney function for up to three years. The goal was to find clues that coul…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Study reveals family experiences with craniosynostosis diagnosis
Knowledge-focused CompletedThis study looked at how families are told their child has craniosynostosis, a condition where skull bones fuse too early. Researchers interviewed and surveyed 574 parents and children to understand the emotional impact and improve the diagnosis process. The goal is to make the a…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Urine test may replace needle biopsy for kidney transplant patients
Knowledge-focused CompletedThis study looked at whether a simple urine test could predict scarring in kidney transplants, instead of using a needle biopsy. Researchers measured certain genetic markers in urine cells from 300 kidney transplant recipients over the first year after transplant. The goal was to…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC