Craniosynostosis
MONDO:0015469Craniosynostosis is defined as the premature fusion of one or more cranial sutures leading to secondary distortion of skull shape resulting in skull deformities with a variable presentation. Craniosynostosis may occur in an isolated setting or as part of a syndrome.
Also known as: craniosynostosis syndrome, premature closure of cranial sutures, CSO
39 clinical trials for this condition and its sub-types, 17 tagged with Craniosynostosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Craniosynostosis
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Syndromic craniosynostosis 1 trial · 22 incl. sub-types
40 sub-types
- Acrocephalosyndactyly 0 trials · 13 incl. sub-types Sub-types →
- Crouzon syndrome-acanthosis nigricans syndrome 4 trials
- Antley-Bixler syndrome 2 trials Sub-types →
- Muenke syndrome 2 trials
- Crouzon syndrome 1 trial Sub-types →
- Shprintzen-Goldberg syndrome 1 trial
- Pseudoaminopterin syndrome 1 trial
- Baller-Gerold syndrome 0 trials
- Beare-Stevenson cutis gyrata syndrome 0 trials
- C syndrome 0 trials
- Curry-Jones syndrome 0 trials
- Hunter-McAlpine craniosynostosis 0 trials
- Lowry-MacLean syndrome 0 trials
- Summitt syndrome 0 trials
- TCF12-related craniosynostosis 0 trials
- Weiss-Kruszka syndrome 0 trials
- X-linked intellectual disability-plagiocephaly syndrome 0 trials
- Acrocephalopolydactyly 0 trials
- Autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome 0 trials
- Cardiocranial syndrome, Pfeiffer type 0 trials
- Cloverleaf skull-asphyxiating thoracic dysplasia syndrome 0 trials
- Cloverleaf skull-multiple congenital anomalies syndrome 0 trials
- Cranioectodermal dysplasia 0 trials Sub-types →
- Craniomicromelic syndrome 0 trials
- Craniosynostosis 2 0 trials
- Craniosynostosis 4 0 trials
- Craniosynostosis and dental anomalies 0 trials
- Craniosynostosis, Herrmann-Opitz type 0 trials
- Craniosynostosis, Philadelphia type 0 trials
- Craniosynostosis-anal anomalies-porokeratosis syndrome 0 trials
- Craniosynostosis-cataract syndrome 0 trials
- Craniosynostosis-fibular aplasia syndrome 0 trials
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome 0 trials
- Craniosynostosis-intracranial calcifications syndrome 0 trials
- Craniotelencephalic dysplasia 0 trials
- Familial scaphocephaly syndrome 0 trials Sub-types →
- Holoprosencephaly-craniosynostosis syndrome 0 trials
- Lethal occipital encephalocele-skeletal dysplasia syndrome 0 trials
- Osteosclerosis-developmental delay-craniosynostosis syndrome 0 trials
- Trigonocephaly-broad thumbs syndrome 0 trials
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Isolated craniosynostosis 1 trial · 3 incl. sub-types
4 sub-types
- Isolated oxycephaly 0 trials · 2 incl. sub-types Sub-types →
- Isolated cloverleaf skull syndrome 0 trials
- Isolated trigonocephaly 0 trials Sub-types →
- Non-syndromic unisutural craniosynostosis 0 trials
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Craniosynostosis syndrome, autosomal recessive 0 trials · 2 incl. sub-types
2 sub-types
- Antley-Bixler syndrome 2 trials Sub-types →
- Cranioectodermal dysplasia 0 trials Sub-types →
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Iida Kannari syndrome 0 trials
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Craniosynostosis Fontaine type 0 trials
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Craniosynostosis autosomal dominant 0 trials
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Craniosynostosis contractures cleft 0 trials
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Craniosynostosis with ectopia lentis 0 trials
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Craniosynostosis, Adelaide type 0 trials
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Mehta lewis patton syndrome 0 trials
Most studied deeper sub-types
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New bladder cancer drug delivery system tested in small japanese study
Disease control OngoingThis early-stage study tests a new treatment called TAR-210 in 5 Japanese patients with a type of bladder cancer that has specific genetic changes (FGFR mutations). The treatment is placed directly into the bladder to deliver the drug erdafitinib. The main goal is to see if it is…
Phase 1 • Sponsor: Janssen Pharmaceutical K.K. • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Can a pill target Hard-to-Treat bile duct cancers? a new drug puts FGFR2 mutations to the test
Disease control OngoingThis early-stage trial is testing an experimental oral drug, TYRA-200, in people with advanced bile duct cancer (intrahepatic cholangiocarcinoma) and other solid tumors that have specific changes in the FGFR2 gene. The study aims to find a safe and effective dose and to see wheth…
Phase 1 • Sponsor: Tyra Biosciences, Inc • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Can a simple drug cut blood loss in Kids' skull surgery?
Disease control OngoingThis study tests whether a medicine called Amicar (EACA) can reduce blood loss in children aged 2 to 36 months who need skull reconstruction for a condition called craniosynostosis. The trial involves 22 children, half receiving Amicar and half receiving a placebo (salt water). T…
Phase 2 • Sponsor: Children's National Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Blood pressure drug may offer clues to chronic pain relief
Knowledge-focused OngoingThis early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for t…
Early phase 1 • Sponsor: University of Kansas Medical Center • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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Hidden danger in the ICU: study reveals how often staff face assault
Knowledge-focused OngoingThis study examines how often healthcare workers in a hospital's intensive care unit (ICU) experience physical, verbal, or sexual assaults from patients or their relatives. Researchers will review medical records of 865 adults who were in the ICU and had a reported incident of vi…
Sponsor: University Hospital, Basel, Switzerland • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New sinus test could change how we treat chronic sinusitis
Knowledge-focused OngoingThis study aims to develop a new way to measure how well the sinuses work in people with chronic sinusitis. About 30 adults with chronic sinusitis and a recent bacterial infection will take the drug ivacaftor. The main goal is to see if a special test can detect changes in sinus …
Sponsor: University of Alabama at Birmingham • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Scientists hunt for hidden genes behind aortic aneurysms
Knowledge-focused OngoingThis study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC