Coronary atherosclerosis

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

Researchers are studying how heart arteries change after a blocked vessel is opened with a paclitaxel drug-coated balloon instead of a metal stent. The balloon delivers a drug to the artery wall and then is removed, leaving no permanent implant. About 150 adults who had this proc…

This registry will follow 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent. The stent is designed to be easier to deliver and stronger than standard stents. Researchers will track how well the stent works and whether it reduces hear…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This trial tests a new device called the Angimis Atherectomy System, which uses laser energy to break up plaque in coronary arteries that are too narrow or hardened for standard balloon or stent procedures. The study enrolls adults with coronary artery disease who have at least o…

This trial tests whether a specialized scoring balloon, called Naviscore, can better prepare calcified coronary arteries before placing a drug-eluting stent. Hardened plaques often prevent stents from expanding fully, raising risks of re-narrowing or clots. About 200 adults with …

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This study tests a new device called the Shockwave C2 Aero, which uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 200 people with coronary artery disease will be enrolled across 8 U.S. sites. The goal is to see if the device works saf…

This study compares two methods to prepare severely calcified heart arteries before placing a stent: a shockwave device that breaks up calcium versus standard balloon treatment. It also tests whether using a special camera inside the artery or standard X-ray leads to better resul…

This study tests a special balloon that uses shockwaves to break up hardened calcium deposits in heart arteries. About 200 people with severe blockages will receive this treatment to see if it safely improves blood flow and reduces the risk of heart attack or death. The goal is t…

This pilot study tests whether taking a synbiotic supplement (a mix of probiotics and prebiotics) for 10 weeks can lower TMAO levels and improve other heart health markers in 80 adults who recently had a heart attack. The goal is to see if changing gut bacteria can help prevent f…

This study compares two methods to treat severely calcified coronary arteries: one uses a special balloon that inflates at very high pressure, and the other combines a rotating burr with sound waves to break up calcium. Researchers will enroll 162 adults with hardened arteries to…

This study looks at whether older adults (65+) who get a heart stent can safely stop one of their blood thinners (aspirin) after just 7 days instead of the usual 3 to 12 months. The goal is to see if this shorter treatment reduces bleeding risks without increasing heart attacks, …

Researchers are testing whether an open-source artificial intelligence model can measure coronary artery calcium on routine chest CT scans that were not originally taken for heart imaging. The study uses existing scans from about 1,950 people at a German hospital, including patie…

This study explores whether a newer type of SPECT/CT scan can accurately measure blood flow in the heart, similar to the more expensive and less available PET scan. Researchers will compare the two imaging methods in 30 adults with coronary artery disease who are already schedule…

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This trial tests whether cutting out a small fibrous structure called the Ligament of Marshall during minimally invasive heart bypass surgery can prevent new-onset atrial fibrillation (an irregular heartbeat) that often occurs after the operation. The study will include 628 adult…

This study will test two different surgical techniques used during heart bypass surgery to see which one better prevents a common complication called atrial fibrillation (irregular heartbeat). The trial will involve 122 adults having their first planned bypass surgery. Researcher…

Researchers are testing whether squeezing a stress ball during femoral arterial sheath removal after coronary angiography can reduce pain and anxiety and improve patient satisfaction. The trial enrolls 34 adults who had a stent or balloon angioplasty through the femoral artery. H…

This trial asks whether discharge education personalized by artificial intelligence can improve recovery after coronary artery bypass grafting. About 80 adults who have had elective bypass surgery will be randomly assigned to receive either standard discharge education or standar…

This trial tests whether a targeted nerve block, called an adductor canal block, can reduce leg pain after coronary artery bypass grafting (CABG) when a leg vein is used as a graft. About 120 adults scheduled for CABG will receive either the block with a numbing medication or a s…

This study tests whether injecting a long-acting numbing medicine (bupivacaine) through chest tubes can safely reduce pain and lower the need for strong painkillers after heart bypass surgery. Sixty adults will receive either the numbing medicine or a saltwater placebo whenever t…

This study looks at whether the urate crystals that cause gout flare-ups in the feet are linked to plaque buildup in the heart's arteries. Researchers will use two types of CT scans to measure urate deposits in the feet and plaque in the coronary arteries of 200 adults with gout …

This study is a large, real-world registry that will include over 10,000 people with coronary artery disease from more than 50 hospitals across China. The goal is to see how often a software tool called QFR, which analyzes angiogram images to guide treatment decisions, is used in…

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This study will follow 600 adults having off-pump heart bypass surgery to see how often memory and thinking problems occur afterward. Participants take a simple thinking test before and after surgery. The goal is to understand what factors might increase the risk of these problem…

This study tests two different computer alerts designed to encourage doctors to refer heart patients to cardiac rehab. About 7,000 adults who had heart surgery or a stent in the past year will take part. The goal is to see if these simple reminders increase the number of people w…

This study will follow 1000 adults in China with severe coronary artery disease who are too high-risk for bypass surgery and need complex angioplasty. Researchers will collect data on their health, procedures, and outcomes for one year to see what factors affect survival and comp…

This observational study will follow 3000 patients with severely calcified coronary arteries who undergo a procedure to open the blockages (PCI). Researchers will track outcomes like heart attacks and repeat procedures over time. The goal is to learn which techniques work best in…

This study will use AI-guided CT scans to look for signs of heart disease in 100 former high-intensity athletes, like NFL alumni or Division I players, aged 30 and older. The goal is to find out how common coronary artery disease is in this group and understand the types of plaqu…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This study will follow 600 people who need either bypass surgery (CABG) or a stent (PCI) to open blocked heart arteries. Researchers will test memory and thinking skills before the procedure and again at 1 month, 1 year, and 2 years after. The goal is to see if one approach leads…

This study looks at whether a special MRI scan can predict if patients will develop an irregular heartbeat (atrial fibrillation) after heart bypass surgery. About 100 adults scheduled for bypass will get an MRI before surgery and wear a heart monitor for a year. The goal is to fi…

This study looks at ways to help surgeons use more artery grafts instead of vein grafts during heart bypass surgery, since artery grafts last longer. It will involve about 8,700 patients across many hospitals. The study does not test a new drug or device, but rather tests trainin…

This study will compare three different fluids used to protect the heart during coronary artery bypass surgery. Researchers will measure tiny particles and immune system markers in the blood to see which fluid causes the least heart muscle injury. The goal is to find the safest a…

This study will create a national registry to collect data on 3,000 adults undergoing coronary artery bypass graft (CABG) surgery in Saudi Arabia. The goal is to track complications, recovery, and quality of life for one year after surgery. This information will help hospitals im…

This study is looking at a specific type of hard plaque in heart arteries called a calcified nodule, which can cause sudden heart attacks and is hard to treat. Researchers will use special cameras inside the arteries to see these plaques in detail and track how patients do over t…