Coronary atherosclerosis

This study tests a new device that uses shock waves to break up calcium deposits in heart arteries before placing a stent. About 335 adults with coronary artery disease will receive this treatment at up to 55 US sites. The goal is to see if the device helps stents work better and…

This study is testing a device that uses sound waves (intravascular lithotripsy) to break up hard calcium deposits in the heart arteries of women with coronary artery disease. The goal is to make it easier to place stents and improve outcomes. About 400 women are being followed t…

This study tests if a drug called inclisiran can reduce fatty plaque buildup in the arteries of people who recently had a heart attack and have high cholesterol. About 318 adults will receive either inclisiran or standard care, and doctors will use special imaging to measure plaq…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study tests a new laser-based device that breaks up calcium deposits in the heart's arteries before placing a stent. About 426 adults with coronary artery disease will receive the treatment. The goal is to see if the device safely improves stent delivery and reduces complica…

This study compares a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time, to a standard permanent metal stent. About 1,859 people with coronary artery disease will receive one of the two stents. The goal is to see if the dissolving stent …

This study tests whether a high-intensity statin and a low-dose anti-inflammatory drug (colchicine) can slow the buildup of artery plaque in people with a high genetic risk for heart disease. Researchers will use CT scans to measure changes in plaque over one year. The trial invo…

This study tests whether advanced CT imaging can help doctors plan better coronary bypass surgery for 200 people with heart disease. Participants get a CT scan before and after surgery to measure blood flow changes. The goal is to improve surgical decisions and reduce chest pain,…

This early study tests a new freezing treatment for people who recently had a heart attack or unstable chest pain. The treatment uses a special balloon to freeze high-risk plaque in the heart's arteries that could rupture and cause another heart attack. The goal is to stabilize t…

This study is tracking 251 patients with symptomatic coronary heart disease who received the EucaLimus stent, a sirolimus-coated device designed to keep arteries open. The goal is to see how well the stent works and how safe it is over the long term in real-world use. Researchers…

This study tests whether taking vitamin K (menaquinone-7) supplements can reduce calcium buildup in heart arteries and improve artery flexibility. Researchers will give 450 adults with early signs of artery calcification either vitamin K or a placebo for a period. The goal is to …

This study tests whether using a shockwave device (intravascular lithotripsy) along with standard artery preparation can improve outcomes for people with moderate to severe coronary artery calcification. About 1,096 participants will be split into two groups: one gets standard pr…

This study looks at whether a special laser can help open heart arteries that are too hard or blocked for standard balloon treatment. About 230 adults with severe coronary artery disease will receive the laser procedure and be followed for one year. The goal is to see if the lase…

This study is looking at people hospitalized for a heart attack (STEMI or NSTEMI) who undergo a procedure to open blocked heart arteries, called percutaneous coronary intervention (PCI) or angioplasty. It compares two groups: those having a standard (non-complex) PCI and those ha…

This study is sequencing the genes of 1665 people aged 45 to 65 to learn how genetic changes relate to health, especially heart disease. Participants provide blood samples and undergo heart tests. The goal is to improve methods for interpreting genetic data and understand how res…

This study compares two procedures—rotational atherectomy and intravascular lithotripsy—used to treat severe calcium deposits in heart arteries. The goal is to see how each technique affects the tiny blood vessels (microcirculation) of the heart and whether one leads to better lo…

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study looks at three ways to treat severely hardened heart arteries before placing a stent: using sound waves (lithotripsy), a high-pressure balloon, or a tiny rotating device (orbital atherectomy). The goal is to see how each method affects the small blood vessels in the he…

This study looks at how combining blood tests (proteomics and genomics) with CT scans can help predict the worsening of coronary artery disease. Researchers will follow 310 adults aged 50-75 who have early signs of plaque in their heart arteries but no symptoms. The goal is to be…