Vitamin k pills could unclog arteries, new study hints
NCT ID NCT05259046
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking vitamin K (menaquinone-7) supplements can reduce calcium buildup in heart arteries and improve artery flexibility. Researchers will give 450 adults with early signs of artery calcification either vitamin K or a placebo for a period. The goal is to see if this simple supplement can lower heart disease risk.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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450 people
The number who actually took part.
- Started
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Jun 2022
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Detectable CAC (Agatson score \>=10) assessed by Cardiac Computed Tomography (CT) scan in the Inter99 20-year follow-up study Exclusion Criteria: * Manifest CVD (prior cerebral infarct, prior myocardial infarct, prior percutaneous coronary intervention or prior coronary artery bypass surgery) * Noise on the CT scan, which complicates an accurate assessment of CAC and interpretation of the CT scan. An example is a pacemaker * Current treatment with Vitamin K antagonist (VKA). * History of coagulation disorders (hemophilia, von Willebrand disease, sickle cell anemia) * Active malignant disease (ongoing treatment) * Previous surgical removal of the thyroid gland, or one or more of the parathyroid glands * Regular use of vitamin K supplements other than trial tablets * Pregnancy or breastfeeding
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Center for Clinical Research and Prevention
Copenhagen, Glostrup, DK-2600, Denmark
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Other studies related to the condition(s) this trial covers.
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