Please sign in to follow a disease.
Connective tissue disorder
MONDO:0003900A disease involving the connective tissue.
Also known as: connective tissue disease, connective tissue disease or disorder, connective tissue diseases, connective tissue disorder, connective tissue disorders, disease of connective tissue, disease or disorder of connective tissue, disease, connective tissue
4637 clinical trials for this condition and its sub-types, 70 tagged with Connective tissue disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Connective tissue disorder
-
Connective tissue neoplasm 1 trial · 2,404 incl. sub-types
13 sub-types
- Bone neoplasm 26 trials · 2,116 incl. sub-types Sub-types →
- Fibroblastic neoplasm 0 trials · 210 incl. sub-types Sub-types →
- Tumor of adipose tissue 1 trial · 98 incl. sub-types Sub-types →
- Chondrosarcoma 39 trials · 44 incl. sub-types Sub-types →
- Tenosynovial giant cell tumor 12 trials · 16 incl. sub-types Sub-types →
- Chondroma 4 trials Sub-types →
- Cholangiolocellular carcinoma 1 trial
- Solitary fibrous tumor/hemangiopericytoma 1 trial
- Angiomyxoma 0 trials
- Cartilage cancer 0 trials
- Dartoic leiomyoma 0 trials
- Lipofibromatosis-like neural tumor 0 trials
- Scirrhous adenocarcinoma 0 trials
-
Rheumatic disorder 90 trials · 1,792 incl. sub-types
30 sub-types
- Rheumatoid arthritis 576 trials · 795 incl. sub-types Sub-types →
- Lupus erythematosus 39 trials · 548 incl. sub-types Sub-types →
- Scleroderma 47 trials · 305 incl. sub-types Sub-types →
- Autoinflammatory syndrome 21 trials · 207 incl. sub-types Sub-types →
- Juvenile idiopathic arthritis 107 trials · 115 incl. sub-types Sub-types →
- Dermatomyositis 81 trials · 100 incl. sub-types Sub-types →
- Polymyalgia rheumatica 30 trials
- Rheumatic fever 16 trials
- Mixed connective tissue disease 15 trials
- Reactive arthritis 6 trials
- Camptodactyly-arthropathy-coxa vara-pericarditis syndrome 4 trials
- Gorham-Stout disease 2 trials
- Sweet syndrome 2 trials
- Palindromic rheumatism 1 trial
- Rheumatic disease of mitral valve 1 trial
- IL10-related early-onset inflammatory bowel disease 0 trials Sub-types →
- LAMA5-related multisystemic syndrome 0 trials
- Reye syndrome 0 trials
- Wissler syndrome 0 trials
- Acroosteolysis dominant type 0 trials
- Chondrocalcinosis 2 0 trials
- Fibroblastic rheumatism 0 trials
- Idiopathic juvenile osteoporosis 0 trials
- Intermittent hydrarthrosis 0 trials
- Interstitial granulomatous dermatitis with arthritis 0 trials
- Isolated sternocostoclavicular hyperostosis 0 trials
- Myalgia-eosinophilia syndrome associated with tryptophan 0 trials
- Progeria-associated arthropathy 0 trials
- Rheumatic pulmonary valve disease 0 trials
- Unexplained long-lasting fever/inflammatory syndrome 0 trials
-
Hereditary disorder of connective tissue 0 trials · 1,311 incl. sub-types
88 sub-types
- Systemic lupus erythematosus 516 trials · 522 incl. sub-types Sub-types →
- Chronic myelogenous leukemia, BCR-ABL1 positive 211 trials · 253 incl. sub-types Sub-types →
- Uterine corpus leiomyoma 104 trials · 109 incl. sub-types Sub-types →
- Acquired polycythemia vera 90 trials
- Chondrosarcoma 39 trials · 44 incl. sub-types Sub-types →
- Type 2 collagenopathy 0 trials · 39 incl. sub-types Sub-types →
- CHILD syndrome 37 trials
- Desmoid tumor 36 trials Sub-types →
- Familial isolated pituitary adenoma 1 trial · 31 incl. sub-types Sub-types →
- Inherited acute myeloid leukemia 1 trial · 25 incl. sub-types Sub-types →
- Hereditary periodic fever syndrome 5 trials · 24 incl. sub-types Sub-types →
- Marfan and Marfan-related disorder 1 trial · 22 incl. sub-types Sub-types →
- VEXAS syndrome 18 trials
- Hypermobility spectrum disorder 16 trials
- Peyronie disease 12 trials
- Aicardi-Goutieres syndrome 9 trials Sub-types →
- Autosomal recessive inherited pseudoxanthoma elasticum 7 trials
- Ewing sarcoma of bone 5 trials
- TREX1-related type 1 interferonopathy 0 trials · 5 incl. sub-types Sub-types →
- Camptodactyly-arthropathy-coxa vara-pericarditis syndrome 4 trials
- Chronic recurrent multifocal osteomyelitis 3 trials · 4 incl. sub-types Sub-types →
- Blau syndrome 3 trials
- Ollier disease 3 trials
- Autoimmune interstitial lung disease-arthritis syndrome 3 trials Sub-types →
- Deficiency of adenosine deaminase 2 3 trials
- Hereditary multiple osteochondromas 3 trials Sub-types →
- Inherited torticollis 3 trials
- Maffucci syndrome 2 trials
- STING-associated vasculopathy with onset in infancy 2 trials
- Familial chilblain lupus 2 trials Sub-types →
- Proteosome-associated autoinflammatory syndrome 2 trials Sub-types →
- Sweet syndrome 2 trials
- ADAR-related type 1 interferonopathy 0 trials · 1 incl. sub-types Sub-types →
- Singleton-Merten dysplasia 1 trial Sub-types →
- Arterial tortuosity syndrome 1 trial
- Cherubism 1 trial Sub-types →
- Hyperparathyroidism 2 with jaw tumors 1 trial
- Infantile myofibromatosis 1 trial Sub-types →
- Neonatal severe primary hyperparathyroidism 1 trial
- Ossification of the posterior longitudinal ligament of the spine 1 trial
- EMILIN-1-related connective tissue disease 0 trials
- Ehlers-Danlos syndrome, kyphoscoliotic type 1 0 trials
- IFIH1-related type 1 interferonopathy 0 trials Sub-types →
- IL10-related early-onset inflammatory bowel disease 0 trials Sub-types →
- LAMA5-related multisystemic syndrome 0 trials
- MASS syndrome 0 trials
- Pelger-Huet-like anomaly and episodic fever with abdominal pain 0 trials
- RNASEH2A-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2B-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2C-related type 1 interferonopathy 0 trials Sub-types →
- RNU7-1-related type 1 interferonopathy 0 trials Sub-types →
- SAMHD1-related type 1 interferonopathy 0 trials Sub-types →
- Sharpin-related autoinflammatory syndrome 0 trials
- Spondyloenchondrodysplasia with immune dysregulation 0 trials
- X-linked reticulate pigmentary disorder 0 trials
- Acroosteolysis dominant type 0 trials
- Aneurysmal bone cyst 0 trials
- Arterial tortuosity-bone fragility syndrome 0 trials
- Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation 0 trials
- Autoinflammatory disease, X-linked 0 trials
- Autoinflammatory disease, multisystem, with immune dysregulation, X-linked 0 trials Sub-types →
- Autoinflammatory disease, systemic, with vasculitis 0 trials
- Autoinflammatory syndrome with immunodeficiency 0 trials
- Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis 0 trials
- Autoinflammatory syndrome, familial, Behcet-like 0 trials Sub-types →
- Bone fragility with contractures, arterial rupture, and deafness 0 trials
- Brittle cornea syndrome 0 trials Sub-types →
- Chondrocalcinosis 2 0 trials
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome 0 trials
- Diaphyseal medullary stenosis-bone malignancy syndrome 0 trials
- Encephalocraniocutaneous lipomatosis 0 trials
- Familial ossifying fibroma 0 trials
- Hyperparathyroidism 1 0 trials
- Hyperparathyroidism 3 0 trials
- Hyperparathyroidism 4 0 trials
- Idiopathic juvenile osteoporosis 0 trials
- Jugulotympanic paraganglioma 0 trials Sub-types →
- Juvenile hyaline fibromatosis 0 trials
- Linkeropathy 0 trials Sub-types →
- Multiple epiphyseal dysplasia due to collagen 9 anomaly 0 trials Sub-types →
- Multiple symmetric lipomatosis 0 trials Sub-types →
- Neonatal inflammatory skin and bowel disease 0 trials Sub-types →
- Progeroid and marfanoid aspect-lipodystrophy syndrome 0 trials
- Pseudo-TORCH syndrome 2 0 trials
- Psoriasis 14, pustular 0 trials
- Pyogenic arthritis-pyoderma gangrenosum-acne syndrome 0 trials
- Thrombocytopenia 6 0 trials
- Trichohepatoenteric syndrome 0 trials Sub-types →
-
Disease of the tendon 126 trials · 192 incl. sub-types
3 sub-types
- Tendinitis 24 trials · 77 incl. sub-types Sub-types →
- Tendon sheath disorder 0 trials · 30 incl. sub-types Sub-types →
- Tendinosis 17 trials
-
Benign connective and soft tissue neoplasm 0 trials · 101 incl. sub-types
5 sub-types
- Bone benign neoplasm 1 trial · 70 incl. sub-types Sub-types →
- Benign soft tissue neoplasm 0 trials · 16 incl. sub-types Sub-types →
- Benign lipomatous neoplasm 0 trials · 15 incl. sub-types Sub-types →
- Benign osteogenic neoplasm 0 trials Sub-types →
- Lipofibromatosis 0 trials
-
Fasciitis 7 trials · 97 incl. sub-types
6 sub-types
- Plantar fasciitis 85 trials
- Necrotizing fasciitis 7 trials
- Eosinophilic fasciitis 1 trial
- Ischemic fasciitis 0 trials
- Nodular fasciitis 0 trials Sub-types →
- Proliferative fasciitis 0 trials
-
Collagenopathy 3 trials · 42 incl. sub-types
3 sub-types
- Type 2 collagenopathy 0 trials · 39 incl. sub-types Sub-types →
- Disseminated eosinophilic collagen disease 0 trials
- Multiple epiphyseal dysplasia due to collagen 9 anomaly 0 trials Sub-types →
-
Interstitial cystitis 39 trials
-
Periostitis 0 trials · 16 incl. sub-types
2 sub-types
- Alveolar periostitis 16 trials
- Orbital periostitis 0 trials
-
Synovitis 15 trials
1 sub-type
- Gonococcal synovitis 0 trials
-
Overlapping connective tissue disease 2 trials · 15 incl. sub-types
2 sub-types
- Mixed connective tissue disease 15 trials
- MASS syndrome 0 trials
-
Panniculitis 3 trials · 6 incl. sub-types
6 sub-types
- Lipodermatosclerosis 1 trial
- Nodular non-suppurative panniculitis 1 trial
- Panniculitis and localized lipodystrophy 1 trial
- Cytophagic histiocytic panniculitis 0 trials
- Erythema nodosum 0 trials
- Lupus erythematosus panniculitis 0 trials
-
Enthesopathy 2 trials · 4 incl. sub-types
5 sub-types
- Enthesitis 2 trials
- Fibular collateral ligament bursitis 0 trials
- Olecranon bursitis 0 trials
- Pes anserinus tendinitis or bursitis 0 trials
- Tibial collateral ligament bursitis 0 trials
-
Ochronosis disorder 1 trial
1 sub-type
- Exogenous ochronosis 0 trials
-
Ainhum 0 trials
-
Interstitial keratitis 0 trials
1 sub-type
- Diffuse interstitial keratitis 0 trials
Most studied deeper sub-types
-
New lupus pill shows promise in Mid-Stage trial
Disease control CompletedThis study tested four doses of cenerimod, a daily pill that calms the immune system, against a placebo in 427 adults with moderate-to-severe lupus. The main goal was to see if cenerimod could reduce lupus disease activity over six months. Researchers also checked for safety and …
Phase 2 • Sponsor: Viatris Innovation GmbH • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
-
New PAH pill aims to delay worsening in large trial
Disease control CompletedThis study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…
Phase 3 • Sponsor: United Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
-
New combo therapy aims to improve lung function in stubborn lung disease
Disease control CompletedThis study tested whether adding rituximab (a drug that calms certain immune cells) to standard mycophenolate mofetil treatment helps people with interstitial lung disease whose lungs are not responding to initial therapy. 122 adults with various ILD types received either rituxim…
Phase 3 • Sponsor: University Hospital, Tours • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
-
Can flu shots protect autoimmune patients?
Disease control CompletedThis study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…
Phase 4 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
-
Scientists hunt for genetic and environmental triggers of rare muscle diseases
Knowledge-focused CompletedThis study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …
Sponsor: National Institute of Environmental Health Sciences (NIEHS) • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
-
Researchers observe bone disorders to expand knowledge
Knowledge-focused CompletedThis study looked at people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was to learn more about these conditions, train doctors, and collect samples for future research. Participants received stand…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
-
Stretchy skin may reveal heart risks in rare genetic condition
Knowledge-focused CompletedThis study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC
-
Gene hunt: scientists probe rare connective tissue variants
Knowledge-focused CompletedThis completed study looked at 32 people with known genetic changes in connective tissue genes to better understand how these changes affect overall health. Participants underwent a range of medical tests and exams over 3-5 days. The goal was to gather information, not to test a …
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
-
Tiny study tests best way to fill gaps after tooth extraction and implant
Knowledge-focused CompletedThis small pilot study looked at 8 adults who needed a single tooth replaced with an immediate dental implant. Researchers compared two methods to manage the gap between the implant and the cheek bone: a bone mineral graft or a soft tissue graft. They used scans and X-rays to mea…
Sponsor: Saint-Joseph University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
-
Immune clues in rare lung disease explored
Knowledge-focused CompletedThis completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
-
New blood tests could help monitor Flare-Ups in kids with arthritis
Knowledge-focused CompletedThis study measured two newer blood markers (calprotectin and serum amyloid protein) alongside standard tests in 20 children with juvenile arthritis and related conditions. The goal was to see if these markers could better track disease flare-ups in everyday clinic visits. The st…
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
-
Blood cell counts may reveal clues about autoimmune diseases
Knowledge-focused CompletedThis study looked at specific cells in the blood of 40 women with either Sjögren's syndrome or systemic sclerosis. The goal was to see if counting these cells could help understand the diseases better. No treatment was given; it was purely an observational study to explore potent…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC