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Congenital syphilis
MONDO:0005714A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia.
Also known as: MTCT of syphilis, congenital syphilis, mother-to-child transmission of syphilis
16 clinical trials for this condition and its sub-types, 7 tagged with Congenital syphilis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Congenital syphilis
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Early congenital syphilis 0 trials
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Late congenital syphilis 0 trials
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New antibiotic shows promise for newborns with dangerous infections
Disease control CompletedThis study looked at how the antibiotic cefiderocol works in hospitalized infants under 3 months old with suspected or confirmed gram-negative bacterial infections. Researchers measured drug levels in the blood and checked for side effects in 30 babies. The goal was to find the r…
Phase 2 • Sponsor: Shionogi • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New antibiotic shows promise for kids with tough infections
Disease control CompletedThis study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…
Phase 2 • Sponsor: Shionogi • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New antibiotic shows promise for kids with tough infections
Disease control CompletedThis study tested a new antibiotic called MK-7655A in 115 children from birth to 18 years old who had serious bacterial infections. The goal was to see if the drug is safe and works better than standard treatments. Children were randomly assigned to receive either the new drug or…
Phase 2/3 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Rapid dual test for HIV and syphilis could save newborns in guatemala
Diagnosis CompletedThis study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…
Sponsor: The University of Texas Health Science Center, Houston • Aim: Diagnosis
Last updated Aug 30, 2026 00:00 UTC
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Can a pill and a vaccine stop STIs in High-Risk men?
Prevention CompletedThis study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if the…
Phase 3 • Sponsor: ANRS, Emerging Infectious Diseases • Aim: Prevention
Last updated Jun 27, 2026 12:04 UTC