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Congenital primary aphakia
MONDO:0012456Congenital primary aphakia (CPA) is characterized by an absence of the lens. The prevalence is unknown. CPA can be associated with variable secondary ocular defects (including aplasia/dysplasia of the anterior segment of the eye, microphthalmia, and in some cases absence of the iris, retinal dysplasia, or sclerocornea). CPA results from early developmental arrest, around the 4th-5th week of embryogenesis, which prevents the formation of any lens structure. Mutations in the FOXE3 gene were identified in three affected siblings born to consanguineous parents.
Also known as: anterior segment dysgenesis 2, multiple subtypes, aphakia, congenital primary, congenital absence of lens, congenital aphakia, ASGD2, CPA, anterior segment dysgenesis 2
19 clinical trials for this condition and its sub-types, 17 tagged with Congenital primary aphakia itself.
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New eye lens could let you focus without glasses after cataract surgery
Disease control OngoingThis study is testing a new type of intraocular lens (IOL) that can be adjusted after cataract surgery using laser energy, potentially allowing the eye to focus at different distances. Researchers will enroll 85 adults with cataracts in both eyes to check safety and how well the …
Sponsor: Alcon Research • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Adjustable lens study tracks Long-Term vision results
Disease control By invitation onlyThis study follows about 500 people who already had cataract surgery with a special adjustable lens (RxSight LAL) or a standard lens. Researchers want to see how well the lens works over time, focusing on vision sharpness and correction of astigmatism. Participants just need to c…
Sponsor: RxSight, Inc. • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New lens implants promise clear vision at all distances after cataract surgery
Disease control OngoingThis study tests two types of advanced lens implants (IOLs) for people having cataract surgery in both eyes. The lenses are designed to help see clearly at far, arm's length, and near distances. Researchers will check safety and how well the lenses work in 110 participants over t…
Sponsor: Alcon Research • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New lens tech aims to sharpen sight after cataracts
Symptom relief OngoingThis study tests new versions of Clareon Vivity Pro intraocular lenses (IOLs) to see if they improve vision better than current lenses. About 231 adults with cataracts in both eyes will receive one new lens and one current lens to compare results. The main goal is to measure how …
Sponsor: Alcon Research • Aim: Symptom relief
Last updated Aug 08, 2026 00:03 UTC
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Eye scanner software update put to the test
Knowledge-focused OngoingThis study compares a new software version (1.5) of the ANTERION eye imaging device against the older cleared version (1.2.4). Researchers will check if the new software gives consistent and accurate measurements of eye structures like cornea thickness and lens thickness. The stu…
Sponsor: Heidelberg Engineering GmbH • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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Eye lens implant safety study pulled before starting
Knowledge-focused CancelledThis study was designed to check the long-term safety and performance of AcrySof IQ Vivity lens implants in people who had them in both eyes for 3 to 5 years. It was a real-world observation, not a treatment test. However, the study was withdrawn before enrolling any participants…
Sponsor: Alcon Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:27 UTC