Complement deficiency
MONDO:0003832A genetic deficiency of any of the component of the complement system (including the classical, alternative, and terminal pathway components), that can either be acquired or inherited.
Also known as: complement activation disease, complement deficiency, disorder of complement activation, immunodeficiency due to a complement cascade component deficiency
68 clinical trials for this condition and its sub-types, 2 tagged with Complement deficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Complement deficiency
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Atypical hemolytic-uremic syndrome 19 trials
4 sub-types
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Classic complement early component deficiency 0 trials · 7 incl. sub-types
13 sub-types
- C1 inhibitor deficiency 5 trials
- Complement component 3 deficiency 2 trials
- Complement component 2 deficiency 0 trials
- Complement component 4a deficiency 0 trials
- Complement component 4b deficiency 0 trials
- Complement component 5 deficiency 0 trials
- Complement component 6 deficiency 0 trials
- Complement component 7 deficiency 0 trials
- Complement component 9 deficiency 0 trials
- Complement component C1r/C1s deficiency 0 trials
- Complement component C1s deficiency 0 trials
- Type I complement component 8 deficiency 0 trials
- Type II complement component 8 deficiency 0 trials
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Disorder of lectin complement activation pathway 0 trials · 1 incl. sub-types
3 sub-types
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Complement factor I deficiency 0 trials
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Complement receptor deficiency 0 trials
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6 sub-types
- C1Q deficiency 0 trials Sub-types →
- Complement component 2 deficiency 0 trials
- Complement component 4a deficiency 0 trials
- Complement component 4b deficiency 0 trials
- Complement component C1r/C1s deficiency 0 trials
- Complement component C1s deficiency 0 trials
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6 sub-types
- Complement component 5 deficiency 0 trials
- Complement component 6 deficiency 0 trials
- Complement component 7 deficiency 0 trials
- Complement component 9 deficiency 0 trials
- Type I complement component 8 deficiency 0 trials
- Type II complement component 8 deficiency 0 trials
Most studied deeper sub-types
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New drug aims to stop rare blood disorder in its tracks
Disease control Not yet recruitingThis Phase II trial tests a drug called NM8074 in 12 adults with atypical hemolytic uremic syndrome (aHUS), a rare condition that causes blood clots, low platelets, and kidney injury. The drug is given by IV infusion over several weeks. The goal is to see if NM8074 can bring bloo…
Phase 2 • Sponsor: NovelMed Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Could a stool sample replace a spinal tap? new study tests Non-Invasive infection detection
Diagnosis Not yet recruitingThis study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like bloo…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis
Last updated Jun 27, 2026 12:36 UTC
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Which infusion pump do patients prefer? new study aims to find out
Symptom relief Not yet recruitingThis study looks at how patients with primary or secondary immunodeficiency feel about using mechanical versus electronic infusion pumps for their immunoglobulin therapy. About 52 adults who have used electronic pumps will try a mechanical pump for three months and then report th…
Sponsor: KORU Medical Systems, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Can a Life-Saving transplant leave hidden scars on a Child's mind?
Knowledge-focused Not yet recruitingThis study looks at children aged 6 to 8 who had a stem cell transplant at least two years ago to treat a primary immunodeficiency—a genetic condition that weakens the immune system. Researchers will use standardized tests and interviews to measure the children's thinking skills,…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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New study aims to unravel mysteries of immune disorder complications
Knowledge-focused Not yet recruitingThis study looks back at medical records of about 60 people with primary immune deficiencies who also developed lymphoproliferative disorders (abnormal growth of immune cells). The goal is to track their health over time, including risks of death, cancer, or organ damage. By iden…
Sponsor: Central Hospital, Nancy, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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New study to measure how immune disorders impact Kids' happiness
Knowledge-focused Not yet recruitingThis study looks at how children aged 6 to 18 with inborn errors of immunity (a condition where the immune system doesn't work properly) feel about their quality of life. Researchers will compare their answers to those of healthy children using a special questionnaire. The goal i…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC