Complement deficiency

MONDO:0003832

A genetic deficiency of any of the component of the complement system (including the classical, alternative, and terminal pathway components), that can either be acquired or inherited.

Also known as: complement activation disease, complement deficiency, disorder of complement activation, immunodeficiency due to a complement cascade component deficiency

68 clinical trials for this condition and its sub-types, 2 tagged with Complement deficiency itself.

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Where it sits in the disease tree

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Part of

↑ Immunodeficiency disease (776) ↑ Inborn error of immunity (343)

Sub-types of Complement deficiency

Atypical hemolytic-uremic syndrome 19 trials
4 sub-types
Classic complement early component deficiency 0 trials · 7 incl. sub-types
13 sub-types
- C1 inhibitor deficiency 5 trials
- Complement component 3 deficiency 2 trials
- Complement component 2 deficiency 0 trials
- Complement component 4a deficiency 0 trials
- Complement component 4b deficiency 0 trials
- Complement component 5 deficiency 0 trials
- Complement component 6 deficiency 0 trials
- Complement component 7 deficiency 0 trials
- Complement component 9 deficiency 0 trials
- Complement component C1r/C1s deficiency 0 trials
- Complement component C1s deficiency 0 trials
- Type I complement component 8 deficiency 0 trials
- Type II complement component 8 deficiency 0 trials
Disorder of lectin complement activation pathway 0 trials · 1 incl. sub-types
3 sub-types
- Mannose-binding lectin deficiency 1 trial
- Immunodeficiency due to MASP-2 deficiency 0 trials
- Immunodeficiency due to ficolin3 deficiency 0 trials
Complement factor I deficiency 0 trials
Complement receptor deficiency 0 trials
Immunodeficiency due to a classical component pathway complement deficiency 0 trials
6 sub-types
- C1Q deficiency 0 trials Sub-types →
- Complement component 2 deficiency 0 trials
- Complement component 4a deficiency 0 trials
- Complement component 4b deficiency 0 trials
- Complement component C1r/C1s deficiency 0 trials
- Complement component C1s deficiency 0 trials
Immunodeficiency due to a late component of complement deficiency 0 trials
6 sub-types
- Complement component 5 deficiency 0 trials
- Complement component 6 deficiency 0 trials
- Complement component 7 deficiency 0 trials
- Complement component 9 deficiency 0 trials
- Type I complement component 8 deficiency 0 trials
- Type II complement component 8 deficiency 0 trials
Recurrent Neisseria infections due to factor D deficiency 0 trials

Most studied deeper sub-types

Atypical hemolytic-uremic syndrome with B factor anomaly (0) Atypical hemolytic-uremic syndrome with C3 anomaly (0) Atypical hemolytic-uremic syndrome with I factor anomaly (0) Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly (0) Atypical hemolytic-uremic syndrome with thrombomodulin anomaly (0) C1Q deficiency 1 (0) C1Q deficiency 2 (0) C1Q deficiency 3 (0)

Including sub-types (68) Tagged with Complement deficiency (2)

Trials to join now! 34 Not yet recruiting 6 Not yet finished but already full! 11 Completed 15 Terminated 2

Complement deficiency

Where it sits in the disease tree

Most studied deeper sub-types

Could a daily pill stop hereditary angioedema attacks?

Promising aHUS drug trial stalls after only 6 patients enrolled