Chronic rapidly progressive glomerulonephritis

This trial tests whether repeated, brief periods of reduced blood flow to the leg—created by inflating a blood pressure cuff—can improve blood pressure, heart rate, and markers of inflammation in people with chronic kidney disease. The procedure, called ischemic preconditioning, …

This study tests whether a carefully controlled low protein diet (about 0.6 grams of protein per kilogram of body weight each day) can help people with advanced chronic kidney disease delay the need for dialysis or a kidney transplant. The study enrolls adults with stage 4-5 or f…

This study tests whether giving two common drugs, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with chronic kidney disease or acute kidney injury. About 100 adults having noncardiac surgery will be randomly assigned to receive one or both drugs…

This study looks at whether lowering high parathyroid hormone levels can help protect bone density in people with advanced chronic kidney disease. About 70 adults aged 50 and older with kidney failure not on dialysis will be assigned to different treatment targets for their hormo…

This study tests whether canagliflozin, a drug used for diabetes, can improve heart structure in people with advanced kidney disease (stage 4 or 5) or on dialysis. About 92 participants will receive either the drug or a placebo for 12 months, with heart changes measured by MRI. T…

This study is testing an artificial intelligence model that reads kidney biopsy images to diagnose chronic kidney disease. Researchers will compare the AI's results to the standard diagnosis made by pathologists. About 2,900 patients with chronic glomerulonephritis will participa…

This study looks at whether levels of a molecule called inorganic pyrophosphate (PPi) in the blood are linked to blood vessel damage in children with chronic kidney disease (CKD). Researchers will compare PPi levels in children with CKD (including those on dialysis or with a kidn…

This study looks at how well the immune system works in people with end-stage kidney disease. Researchers will take blood samples from 100 patients and healthy donors to study T-cells, a key part of the immune system. They also plan to test a lab technique to restore T-cell funct…

This study is testing a new ultrasound method to look at tiny blood vessels in the kidneys of people with nephritis (kidney inflammation). Researchers will use contrast-enhanced ultrasound and ultrasound localization microscopy to create detailed images of kidney blood flow. The …