Chronic otitis media

This early-phase trial tested a special insulin gel applied directly to the ear drum after surgery to repair a long-standing hole. Fifty adults with dry ear drum perforations received either the insulin gel or a plain foam control. The insulin group showed significantly better he…

This trial tests whether a daily supplement containing omega-3s, Spirulina, magnesium, and vitamin B6 can help adults with persistent middle ear fluid — a condition that can cause hearing loss and ear fullness. Over 500 adults aged 18 to 70 with confirmed otitis media with effusi…

This study tested whether using a patient's own platelet-rich plasma (PRP) during eardrum repair surgery improves healing. 48 adults with chronic ear infections and eardrum holes were split into two groups: one got PRP-soaked sponges placed in the ear during surgery, the other go…

This study compared two ways of preparing a tissue graft (temporalis fascia) for repairing holes in the eardrum caused by chronic ear infections. 92 adults aged 18–60 received either a wet or dry graft during tympanoplasty surgery. Researchers checked hearing improvement and graf…

This study compares two surgical techniques for repairing large eardrum holes caused by chronic ear infections. The interlay method places the graft between eardrum layers, while the underlay method places it beneath. Researchers measured hearing improvement in 60 adults to see w…

This study tested a low-cost, smartphone-connected device that checks middle ear health. Researchers compared it to standard equipment in 30 adults and children. The goal is to make ear screening affordable and easy for rural communities, reducing preventable hearing loss.

This study tested whether laser acupuncture, a painless procedure using low-level laser light on specific points, can improve middle ear function in children aged 2-10 with otitis media with effusion (fluid behind the eardrum). Thirty-two children received either real or sham las…

This study tested whether a device called AirOFit PRO, which guides children through blowing exercises, can help clear fluid behind the eardrum. Fifty-one children with otitis media with effusion (OME) used the device three times daily. The goal was to see if the exercises improv…

This study looked at whether placing small tubes in the ears of children aged 1-4 with chronic ear fluid (otitis media with effusion) improves their sleep and quality of life. Sixty children were randomly assigned to either receive ear tubes or not. Sleep was measured with a wris…

This study tested two drugs used to reverse muscle relaxants after surgery: sugammadex and a combination of neostigmine and glycopyrrolate. The goal was to see which one better prevents urinary retention in 124 patients having ear, nose, or throat surgery who were at high risk du…

This study tested whether a low dose of tranexamic acid, a drug that helps blood clot, could reduce bleeding during middle ear surgery. 100 adults undergoing microscopic or endoscopic ear surgery received either the drug or a placebo. The goal was to see if the drug improved the …

This study looks at children aged 8 to 18 having surgery to repair a hole in the eardrum, a procedure called type 1 tympanoplasty. Researchers want to know if the size of the mastoid and middle ear spaces affects how well the surgery works. They will compare two graft materials, …