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Insulin gel mends ear drums faster in small trial

NCT ID NCT07535827

Disease control Sponsor: Deraya University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 04, 2026 · Updated 6 times

Summary

This early-phase trial tested a special insulin gel applied directly to the ear drum after surgery to repair a long-standing hole. Fifty adults with dry ear drum perforations received either the insulin gel or a plain foam control. The insulin group showed significantly better healing at follow-ups up to two months. While promising, the study is small and early, so more research is needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
insulin gel (applied directly to the ear drum)
What this could lead to
If confirmed in larger trials, this insulin gel could become a simple, low-cost way to help ear drum perforations heal faster after surgery.
What could go wrong
This was a very small, early-phase trial (50 people). The results need to be repeated in larger, longer studies before we know if it really works safely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

50 people

The number who actually took part.

Started

Mar 2026

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * aged 18 years or older, * with a confirmed diagnosis of tubotympanic CSOM without discharge for at least three months, * an intact ossicular chain, normal middle ear mucosa on otoscopic or endoscopic examination, * conductive hearing loss indicated by an air-bone gap less than 30 dB Exclusion Criteria: * unfit for general anesthesia, * had cervical spine disorders limiting operative positioning, * active otorrhea, granulation tissue, or mucosal inflammation

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Conditions

The condition(s) this trial relates to.

chronic purulent otitis media chronic tubotympanic suppurative otitis media Insulin Resistance Tympanic Membrane Perforation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tympanic membrane perforation

Contacts and locations

Locations

  • Minia university hospital

    Minya, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.