Childhood acute lymphoblastic leukemia

This study tests a new way to treat children and teens with acute lymphoblastic leukemia (ALL), the most common childhood cancer. Researchers are using updated risk factors to decide how strong chemotherapy should be and adjusting doses of a key drug based on blood levels. The go…

This study tests a precise radiation method called total marrow and lymphoid irradiation (TMLI) given with two chemotherapy drugs (etoposide and cyclophosphamide) before a donor stem cell transplant. The goal is to safely deliver higher radiation doses to the bone marrow to wipe …

This trial investigates a new type of immunotherapy called CAR T-cell therapy that targets two proteins, CD19 and CD22, found on B-cell leukemia cells. The therapy is given along with chemotherapy to children and young adults whose leukemia has come back or has not responded to s…

This study looks at whether children and teens being treated for acute lymphoblastic leukemia can follow a low-glycemic (low-sugar) diet for six months. The goal is to see if this diet is practical and helps manage weight during cancer treatment. About 88 participants will track …

This study was designed to test the safety and best dose of the drug revumenib in children and young adults with certain types of leukemia (ALL, AML, or mixed phenotype) after they have received a stem cell transplant. The goal was to see if revumenib could help prevent the cance…

This study tests whether using a special augmented reality (AR) game called Little NIRVANA, along with numbing cream, can help children ages 2 to 8 feel less pain and anxiety when getting an IV in the emergency room. About 130 kids will be randomly assigned to get either the AR g…

This trial tests whether a smartphone-based virtual reality tool (VR-PAT) can reduce pain during at-home burn dressing changes in children aged 6 to 17. Half of the 200 participants will use VR-PAT during their daily dressing changes, while the other half will not. Researchers wi…

This study tests a quick, non-invasive brain scan called Magnetic Resonance Fingerprinting (MRF) in children and young adults with acute leukemia. The goal is to see if the scan can detect early brain changes caused by chemotherapy. Participants also take a fun, game-like memory …

This study looks at whether a computer-based test can reveal how young adult survivors of childhood leukemia feel about exercise. About 125 survivors will take the test before and after a stress test and share their thoughts in an interview. The goal is to see if this approach is…

This study looks at how different infant diets affect gut bacteria in healthy, full-term babies. Researchers are comparing a standard formula, a new formula designed to be more like breast milk (Enfamil NeuroPro), and breast milk itself. They will track changes in gut bacteria, g…

This study looks back at the medical records of 102 adults with B-cell acute lymphoblastic leukemia who received the drug inotuzumab ozogamicin. The goal is to see how well the drug worked and how safe it was. No new treatments are given; researchers are just gathering existing d…