Central nervous system neoplasm
MONDO:0006130A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia.
Also known as: CNS neoplasm, CNS tumor, CNS tumour, brain/spinal cord tumor, brain/spinal cord tumour, central nervous system neoplasm, central nervous system neoplasm (disease), central nervous system tumor
3348 clinical trials for this condition and its sub-types, 51 tagged with Central nervous system neoplasm itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system neoplasm
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Central nervous system cancer 130 trials · 1,699 incl. sub-types
20 sub-types
- Malignant glioma 250 trials · 915 incl. sub-types Sub-types →
- Brain cancer 680 trials · 900 incl. sub-types Sub-types →
- Primary central nervous system lymphoma 92 trials · 103 incl. sub-types Sub-types →
- Central nervous system sarcoma 2 trials · 74 incl. sub-types Sub-types →
- Spinal cord cancer 21 trials · 57 incl. sub-types Sub-types →
- Central nervous system primitive neuroectodermal neoplasm 8 trials · 24 incl. sub-types Sub-types →
- Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor 1 trial · 22 incl. sub-types Sub-types →
- Malignant tumor of meninges 0 trials · 14 incl. sub-types Sub-types →
- Malignant adrenal gland pheochromocytoma 11 trials
- Central nervous system germinoma 2 trials · 4 incl. sub-types Sub-types →
- Central nervous system melanocytic neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
- Choriocarcinoma of the central nervous system 0 trials Sub-types →
- Embryonal carcinoma of the central nervous system 0 trials Sub-types →
- Malignant carotid body paraganglioma 0 trials
- Malignant central nervous system mesenchymal, non-meningothelial neoplasm 0 trials Sub-types →
- Malignant jugulotympanic paraganglioma 0 trials
- Mixed germ cell tumor of central nervous system 0 trials Sub-types →
- Pheochromocytoma/paraganglioma syndrome 2 0 trials
- Pheochromocytoma/paraganglioma syndrome 5 0 trials
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Brain neoplasm 246 trials · 1,077 incl. sub-types
17 sub-types
- Brain cancer 680 trials · 900 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 114 incl. sub-types Sub-types →
- Infratentorial neoplasm 6 trials · 114 incl. sub-types Sub-types →
- Brainstem neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Primary brain neoplasm 87 trials · 92 incl. sub-types Sub-types →
- Hypothalamic neoplasm 3 trials · 85 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Choroid plexus neoplasm 5 trials · 18 incl. sub-types Sub-types →
- Neoplasm of cerebral hemisphere 3 trials · 14 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cerebellopontine angle tumor 1 trial Sub-types →
- Dysembryoplastic neuroepithelial tumor 1 trial
- Childhood brain meningioma 0 trials
- Olfactory groove meningioma 0 trials
- Optic tract meningioma 0 trials Sub-types →
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Tumor of meninges 1 trial · 123 incl. sub-types
5 sub-types
- Meningioma 108 trials · 122 incl. sub-types Sub-types →
- Malignant tumor of meninges 0 trials · 14 incl. sub-types Sub-types →
- Benign neoplasm of meninges 0 trials · 5 incl. sub-types Sub-types →
- Diffuse leptomeningeal melanocytosis 0 trials
- Familial multiple meningioma 0 trials
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Central nervous system hematopoietic neoplasm 0 trials · 107 incl. sub-types
4 sub-types
- Primary central nervous system lymphoma 92 trials · 103 incl. sub-types Sub-types →
- Central nervous system leukemia 4 trials
- Intracranial cavernous angioma 0 trials
- Pituitary gland basophil adenoma 0 trials
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Spinal cord neoplasm 36 trials · 77 incl. sub-types
8 sub-types
- Spinal cord cancer 21 trials · 57 incl. sub-types Sub-types →
- Childhood spinal cord tumor 1 trial
- Benign neoplasm of spinal cord 0 trials Sub-types →
- Cervicomedullary junction neoplasm 0 trials
- Conus medullaris neoplasm 0 trials
- Neurofibroma of spinal cord 0 trials
- Spinal cord dermoid cyst 0 trials
- Spinal meningioma 0 trials
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Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types
3 sub-types
- Paraganglioma 53 trials · 57 incl. sub-types Sub-types →
- Ganglioneuroma 5 trials Sub-types →
- Sympathetic neurilemmoma 0 trials
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Central nervous system organ benign neoplasm 1 trial · 57 incl. sub-types
13 sub-types
- Craniopharyngioma 29 trials Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Benign neoplasm of meninges 0 trials · 5 incl. sub-types Sub-types →
- Central nervous system hemangioma 0 trials · 2 incl. sub-types Sub-types →
- Multinodular and vacuolating neuronal tumor 2 trials
- Diffuse leptomeningeal glioneuronal tumor 1 trial
- Polymorphous low grade neuroepithelial tumor of the young 1 trial
- Benign neoplasm of peripheral nervous system 0 trials Sub-types →
- Benign neoplasm of spinal cord 0 trials Sub-types →
- Central nervous system chondroma 0 trials
- Central nervous system leiomyoma 0 trials
- Central nervous system lipoma 0 trials Sub-types →
- Myxoid glioneuronal tumor 0 trials
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Central nervous system germ cell tumor 6 trials · 9 incl. sub-types
6 sub-types
- Central nervous system germinoma 2 trials · 4 incl. sub-types Sub-types →
- Malignant pineal area germ cell neoplasm 2 trials · 3 incl. sub-types Sub-types →
- Central nervous system nongerminomatous germ cell tumor 2 trials Sub-types →
- Childhood central nervous system germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Adult central nervous system germ cell tumor 0 trials Sub-types →
- Mixed germ cell tumor of central nervous system 0 trials Sub-types →
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Epidural abscess 5 trials
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Optic nerve neoplasm 1 trial · 4 incl. sub-types
3 sub-types
- Optic nerve glioma 2 trials · 3 incl. sub-types Sub-types →
- Optic nerve sheath meningioma 1 trial
- Bilateral meningioma of optic nerve 0 trials
Most studied deeper sub-types
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Can a Two-Drug combo beat tough childhood cancers?
Disease control CompletedThis phase 2 trial is testing whether combining two chemotherapy drugs, gemcitabine and oxaliplatin, can shrink tumors in children and adolescents with certain solid cancers that have come back or not responded to standard treatment. The study includes patients with medulloblasto…
Phase 2 • Sponsor: Gustave Roussy, Cancer Campus, Grand Paris • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New hope for kids with resistant tumors? early trial tests CUDC-907
Disease control CompletedThis early-phase study tested a new drug called CUDC-907 in 26 children and young adults (ages 1-21) with cancers that had come back or stopped responding to treatment, including solid tumors, brain tumors, and lymphoma. The main goal was to find a safe dose and check for side ef…
Phase 1 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Glow-in-the-Dark dye could help surgeons spot hidden brain tumors
Disease control CompletedThis completed Phase 1 trial tested whether a dye called indocyanine green (ICG) can make brain tumor cells glow during surgery, helping surgeons see and remove them more completely. 363 adults with brain tumors received an ICG injection before surgery, and special cameras captur…
Phase 1 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New hope for kids with rare cancers: targeted drug shows promise
Disease control CompletedThis study tested a drug called avapritinib in 29 children aged 2 to 18 with advanced solid tumors that have specific genetic changes (KIT or PDGFRA). The goal was to see if the drug is safe and can shrink or control the tumors. Participants took the drug by mouth, and researcher…
Phase 1/2 • Sponsor: Blueprint Medicines Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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New Gadolinium-Free MRI dye shows promise for brain scans
Diagnosis CompletedThis study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…
Phase 2 • Sponsor: Reveal Pharmaceuticals Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 08:06 UTC
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Simple skin care may shield kids from cancer drug side effects
Symptom relief CompletedThis study tested a preventive skin care routine in 14 children (ages 6 months to 18 years) with brain tumors who were receiving targeted therapy (BRAF, MEK, or Pan-RAF inhibitors). The goal was to see if gentle skin care and sun protection could reduce or prevent skin reactions …
Phase 2 • Sponsor: Dana-Farber Cancer Institute • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
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Can a phone call help cancer survivors get the genetic answers they need?
Knowledge-focused CompletedThis study looked at whether offering genetic counseling by phone or video could help more childhood cancer survivors get genetic testing. About 391 survivors took part, comparing remote counseling to usual care. The goal was to see if remote services increase testing uptake and …
Sponsor: University of Chicago • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Genetic testing could unlock new treatments for kids with brain cancer
Knowledge-focused CompletedThis study tested whether a detailed genetic analysis of tumor tissue could find treatment targets in 80 children with recurrent or very high-risk brain tumors. The goal was to see if this approach is practical and can help doctors choose personalized therapies. No new drugs were…
Sponsor: Masaryk University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Brain tumor drug implant under the microscope: how safe is it?
Knowledge-focused CompletedThis study followed 272 people with brain tumors who received Gliadel Wafer, a chemotherapy implant placed during surgery. Researchers tracked how long patients lived and whether the tumor came back, as well as any side effects. The goal was to see how the treatment works in real…
Sponsor: Arbor Pharmaceuticals, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Proton Therapy's Long-Term effects on Kids' brains under the microscope
Knowledge-focused CompletedThis study followed 155 children with brain or central nervous system tumors who received proton radiation therapy at Massachusetts General Hospital. Researchers measured changes in thinking skills, behavior, and use of special education services one year or more after treatment.…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC