Castleman disease
MONDO:0015564Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.
Also known as: AFLH, Castleman disease, Castleman's disease, Castleman's tumor, Castleman's tumour, GLNH, angiofollicular ganglionic hyperplasia, angiofollicular lymph hyperplasia
64 clinical trials for this condition and its sub-types, 8 tagged with Castleman disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Castleman disease
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Multicentric Castleman disease 13 trials
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1 sub-type
- Castleman-Kojima disease 0 trials
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Localized Castleman disease 1 trial
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Pediatric Castleman disease 0 trials
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New hope for rare immune disorder: ruxolitinib trial targets castleman disease
Disease control Recruiting nowThis study tests the drug ruxolitinib in 14 adults with idiopathic multicentric Castleman disease (iMCD) whose condition did not improve with standard therapies like siltuximab or tocilizumab. The goal is to see if ruxolitinib can improve symptoms such as fatigue, fever, and nigh…
Phase 2 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Banking blood and bone marrow to decode plasma cell disorders
Knowledge-focused Recruiting nowResearchers at Peking University First Hospital are building a prospective cohort of 2,000 people with plasma cell disorders, including multiple myeloma, amyloidosis, and related conditions. Participants give blood, bone marrow, and urine samples before and after treatment, and t…
Sponsor: Peking University First Hospital • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists hunt for genetic clues in Virus-Linked cancers
Knowledge-focused Recruiting nowThis study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Massive castleman disease registry launches to unlock secrets of rare illness
Knowledge-focused Recruiting nowThis study is a global registry for people with Castleman disease, a rare lymph node disorder. Researchers will collect medical records, lab results, and patient surveys from up to 1,000 participants to better understand symptoms, treatments, and outcomes. No experimental drug or…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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New registry aims to unlock secrets of rare blood disorders
Knowledge-focused Recruiting nowThis study creates a registry for adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Researchers will collect health information and optional blood samples to better understand these conditions. The goal is to gather data that could support future resear…
Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC