Calcium metabolic disease

This study tests whether a citrate-based dialysis fluid with extra magnesium can slow or prevent blood vessel hardening in adults on long-term hemodialysis. Eighty stable patients will receive either the new fluid or a standard one for 12 months. Researchers will measure blood ma…

This study tests a new drug called EPN-701 for calciphylaxis, a rare condition causing painful skin sores with no approved treatment. About 60 adults with moderate to severe pain and at least one open sore will receive the drug. The main goals are to see if EPN-701 safely reduces…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests a device that uses sound waves (lithotripsy) to break up calcium buildup in the carotid arteries—the main arteries in the neck—before placing a stent to keep them open. The goal is to see if this approach reduces complications like stroke, heart attack, or death …

This trial tests whether tocilizumab, an anti-inflammatory drug, can stop the progression of calciphylaxis—a rare condition where calcium buildup blocks skin blood vessels, causing painful, non-healing wounds. Ten adults with calciphylaxis and end-stage kidney disease will receiv…

This study tests whether a wearable goggle system that makes parathyroid glands glow can help surgeons find and protect them during thyroid removal. About 280 adults having thyroid surgery will take part. The goal is to reduce the risk of low calcium levels after surgery, a commo…

This study compares two methods to treat severely calcified coronary arteries: one uses a special balloon that inflates at very high pressure, and the other combines a rotating burr with sound waves to break up calcium. Researchers will enroll 162 adults with hardened arteries to…

Researchers at Massachusetts General Hospital are studying whether molecular imaging and detailed biological profiling can predict how quickly aortic stenosis gets worse. The trial enrolls 100 adults with mild to moderate calcific aortic stenosis. Participants receive a baseline …

Paraffin disease happens when people inject paraffin oil into muscle for cosmetic enlargement, causing chronic inflammation, high blood calcium, kidney stones, and kidney damage. Researchers are testing whether empagliflozin or losartan, two drugs already used for kidney protecti…

Researchers at Assiut University are studying whether ionized calcium levels, measured from a routine blood sample when a patient enters the ICU, can signal how severe sepsis or septic shock is. The study follows 160 adults admitted to intensive care within 24 hours of presentati…

This study will use ultrasound to check for medial arterial calcification (hardening of the arteries) in 60 healthy endurance athletes. The goal is to find out how common this condition is in this group and see if it relates to their training habits or heart risk factors. Partici…

This study looks at whether having one or two faulty copies of the CYP24A1 gene makes kidney stones more likely. Researchers will compare people with different gene variants to see how often stones occur. The goal is to better understand the genetic factors behind this common and…

This study will translate and test two questionnaires (HPES-Symptom and HPES-Impact) for Greek-speaking adults with chronic hypoparathyroidism. Researchers will enroll 200 patients across several hospitals in Greece. The goal is to ensure the questionnaires accurately capture pat…