Brain neoplasm

Researchers are testing an experimental therapy called SRN-101 in adults with recurrent high-grade glioma, an aggressive brain cancer that has returned after standard treatment. Participants receive SRN-101 directly into the tumor before planned surgery to remove it. The trial's …

This trial compares three common anesthetics, ciprofol, propofol, and sevoflurane, to see which one best prevents delirium, a sudden state of confusion and memory problems, in older adults after brain tumor surgery. About 381 people aged 65 to 90 will be randomly assigned to rece…

This study explores whether a non-invasive EEG-based technique can map cognitive networks in the brain before, during, and after tumor surgery. The goal is to help surgeons avoid damaging areas critical for memory and thinking. Ten adults with brain glioma will undergo neuropsych…

This study tests whether the anti-inflammatory drug ulinastatin can prevent strokes in people having brain tumor removal. About 1,370 patients will receive either ulinastatin or a placebo before and after surgery. The goal is to see if the drug lowers the chance of having a strok…

This study tests whether taking memantine (a memory drug) plus raloxifene (a bone drug) can help prevent memory loss in adults receiving radiation for brain tumors. About 108 participants will be followed with MRI scans to see if their brain's memory center stays healthier. The g…

This early study tests a new approach for people with slow-growing brain tumors located in areas that control movement. A small device placed on the skull delivers mild electrical stimulation while patients do physical therapy, aiming to retrain the brain so that critical functio…

This trial tests a new AI device that helps surgeons see brain tumors on ultrasound images during surgery. The AI highlights tumor tissue in real time, which may help remove more of the tumor while protecting healthy brain. The study involves 100 adults scheduled for brain tumor …

Gliomas are the most common primary brain tumors in adults, and knowing whether a tumor is low-grade or high-grade before surgery guides treatment and prognosis. Currently, doctors need a tissue sample from surgery or biopsy to grade a glioma, and standard MRI scans often cannot …

This study tests whether a portable, radiation-free ultrasound performed at the bedside can accurately detect brain injuries in children, compared to the standard head CT scan. Researchers will enroll 220 children aged 2-17 who are already scheduled for a head CT due to suspected…

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

This study looks at 69 past brain scans using a special tracer called [18F]FET to see if it can more accurately tell the difference between a returning tumor and changes caused by previous treatment. Researchers will analyze both still and time-lapse images to find better ways to…

This study tests a new imaging device called cCeLL that uses a fluorescent dye to help surgeons see brain tumor tissue in real time during surgery. Thirty adults with suspected brain tumors will have their tumor tissue examined both by the device and by standard lab analysis. The…

Some brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that makes surgical removal difficult and risky. This study tests whether blocking the tumor's feeding blood vessels with a catheter procedure before surgery reduces blee…

This study tests whether a year of music training can improve thinking, memory, and quality of life in children who have recovered from brain tumors. About 236 children aged 7-16 will either receive regular care or join a ukulele program with weekly group and online sessions. Res…

This study tests whether a simple online computer game can help children with brain tumors think faster. 300 kids will do 15 minutes of cognitive training, 5 times a week for 8 weeks. Researchers will check if the training is easy to do at home and if it actually improves process…

This Mayo Clinic study will test whether a special ultrasound technique, called shear wave elastography, can measure how stiff brain tumors are compared to healthy brain tissue during surgery. Researchers will enroll 30 adults with newly diagnosed or recurrent brain tumors. The g…

This early study tests whether asciminib, a drug already approved for leukemia, can get into brain tumors in children and young adults (ages 6-25) with recurrent brain tumors. Some participants will also get sildenafil to see if it helps the drug enter the tumor. The main goal is…

This early study tests a new, flexible brain electrode in 5 people having brain surgery for tumors or epilepsy. The electrode is designed to be placed through a small hole in the skull, which may be safer than traditional methods. The main goal is to see if it works well and is s…

This study looks at why some older adults experience delirium, a state of confusion, after brain tumor surgery. Researchers will monitor blood pressure and brain wave activity during surgery in 164 patients to see if these factors are linked to postoperative delirium. The goal is…

This study will follow 40 adults with brain tumors who are scheduled for standard brain radiotherapy. Researchers will collect blood samples, perform brain scans, and give thinking and quality-of-life tests before and after treatment. The goal is to identify biological markers th…

This study uses thin, flexible electrode arrays placed on the brain to record electrical signals in people with epilepsy who are already undergoing surgery. Researchers aim to better understand how the brain processes sensory information, memory, and language, and how epilepsy af…

This study explores whether self-administered digital cognitive tests can accurately measure thinking skills like attention, memory, and processing speed in people with primary central nervous system lymphoma or low-grade gliomas. Participants will complete both digital tests (on…

This study develops an artificial intelligence model that can classify brain tumors into categories, families, and specific diagnoses using only standard stained tissue slides. Researchers will train the AI on 20,000 archived images from two hospitals and test its accuracy agains…

This study tests whether speech can be decoded from brain activity recorded during awake brain tumor surgery. Twenty adult patients will have a special graphene electrode grid placed on their brain surface for up to two hours while they name pictures. Researchers will use machine…

This study tests whether mixed reality glasses can help surgeons plan incisions for brain tumor removal more accurately and quickly than current methods. About 54 adults needing brain surgery will be observed as surgeons use the device during standard care. The goal is to see if …

This study tests whether a camera can record useful video of the brain during neurosurgery to help surgeons tell healthy tissue from diseased tissue. Researchers will record 50 adult patients undergoing brain surgery for tumors, epilepsy, or other conditions. The goal is to see i…

This study will test if a simple eye ultrasound can measure brain pressure in 60 adults before and after brain tumor surgery. The ultrasound looks at the optic nerve sheath diameter, which may change with pressure. If it works, it could offer a safer, non-invasive alternative to …

This study aims to better understand which brain areas handle tasks like memory, language, and perception. 120 patients with brain tumors will perform short cognitive tests before and during awake surgery. By comparing test results, researchers hope to create a map of brain regio…