Brain recordings during awake surgery aim to read patients' thoughts
NCT ID NCT07499479
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether speech can be decoded from brain activity recorded during awake brain tumor surgery. Twenty adult patients will have a special graphene electrode grid placed on their brain surface for up to two hours while they name pictures. Researchers will use machine learning to see if they can predict which picture the patient named from the brain signals alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- INBRAIN Graphene Cortical Interface (high-density graphene ECoG grid)
- What this could lead to
- If successful, this could lead to better ways to map language areas during brain surgery, potentially improving surgical outcomes.
- What could go wrong
- This is a very early, small study (20 participants) focused on recording, not treatment. The decoding may not work as hoped, and results may not apply to other patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 84 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients 18 years of age or older. 2. Patients with a brain tumor requiring surgery under "awake" conditions with intraoperative placement of ECoG electrodes at Lariboisière Hospital. 3 -Patients with tumor locations close to language processing areas. 4 -Patients having given consent during the interview with the neurosurgeon. Exclusion Criteria: 1. Patients with severe cognitive impairments that would prevent understanding and performing the image-naming task, 2. Patients with major psychiatric disorders that could affect their ability to participate in the research, 3. Patients with inoperable tumors, 4. Patients with tumor locations incompatible with safe or effective placement of ECoG electrodes, 5. Females that are breastfeeding or females with childbearing potential with positive urine pregnancy test or not using adequate contraception, 6. Patients unable to provide informed consent due to cognitive or language limitations, 7. Patients who have any electrical stimulator or any active implanted medical device that uses high magnetic or electrical currents (e.g. patients with pacemaker defibrillator, neurostimulator, drugs pumps, retinal and cochlear device), 8. Any wearable medical device that may cause troubles to the investigational devices and injuries to the participants, 9. Patients with medical contraindications to general or local anesthesia required for surgery, 10. Patients with an active infection or infectious skin lesions on the scalp, 11. Patients with a current use or a recent history of illicit drug(s) use or alcohol abuse (defined as frequent or daily consumption of more than four alcoholic drinks per day), 12. Patients with contraindications to any surgical procedure, 13. Patients undergoing treatment with anticoagulants, platelet aggregation inhibitors, or non-steroidal anti-inflammatory drugs, 14. Patients who decline to participate in the study, 15. Any specially protected person: adults protected by law; persons hospitalized without their consent, at the request of a third party or ex officio; persons deprived of their liberty by a judicial decision, 16. Participation in another interventional study or being in the exclusion period at the end of a previous study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of neurosurgery Lariboisière hospital-APHP
Paris, Île-de-France Region, 75010, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Mapping the hidden toll of brain radiation on young minds