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Brain recordings during awake surgery aim to read patients' thoughts

NCT ID NCT07499479

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether speech can be decoded from brain activity recorded during awake brain tumor surgery. Twenty adult patients will have a special graphene electrode grid placed on their brain surface for up to two hours while they name pictures. Researchers will use machine learning to see if they can predict which picture the patient named from the brain signals alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
INBRAIN Graphene Cortical Interface (high-density graphene ECoG grid)
What this could lead to
If successful, this could lead to better ways to map language areas during brain surgery, potentially improving surgical outcomes.
What could go wrong
This is a very early, small study (20 participants) focused on recording, not treatment. The decoding may not work as hoped, and results may not apply to other patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Oct 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 84 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients 18 years of age or older. 2. Patients with a brain tumor requiring surgery under "awake" conditions with intraoperative placement of ECoG electrodes at Lariboisière Hospital. 3 -Patients with tumor locations close to language processing areas. 4 -Patients having given consent during the interview with the neurosurgeon. Exclusion Criteria: 1. Patients with severe cognitive impairments that would prevent understanding and performing the image-naming task, 2. Patients with major psychiatric disorders that could affect their ability to participate in the research, 3. Patients with inoperable tumors, 4. Patients with tumor locations incompatible with safe or effective placement of ECoG electrodes, 5. Females that are breastfeeding or females with childbearing potential with positive urine pregnancy test or not using adequate contraception, 6. Patients unable to provide informed consent due to cognitive or language limitations, 7. Patients who have any electrical stimulator or any active implanted medical device that uses high magnetic or electrical currents (e.g. patients with pacemaker defibrillator, neurostimulator, drugs pumps, retinal and cochlear device), 8. Any wearable medical device that may cause troubles to the investigational devices and injuries to the participants, 9. Patients with medical contraindications to general or local anesthesia required for surgery, 10. Patients with an active infection or infectious skin lesions on the scalp, 11. Patients with a current use or a recent history of illicit drug(s) use or alcohol abuse (defined as frequent or daily consumption of more than four alcoholic drinks per day), 12. Patients with contraindications to any surgical procedure, 13. Patients undergoing treatment with anticoagulants, platelet aggregation inhibitors, or non-steroidal anti-inflammatory drugs, 14. Patients who decline to participate in the study, 15. Any specially protected person: adults protected by law; persons hospitalized without their consent, at the request of a third party or ex officio; persons deprived of their liberty by a judicial decision, 16. Participation in another interventional study or being in the exclusion period at the end of a previous study.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Department of neurosurgery Lariboisière hospital-APHP

    Paris, Île-de-France Region, 75010, France

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