Brain disorder
MONDO:0005560A disease affecting the brain or part of the brain.
Also known as: brain disease, brain disease or disorder, disease of brain, disease or disorder of brain, disorder of brain, encephalopathy
16709 clinical trials for this condition and its sub-types, 137 tagged with Brain disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Brain disorder
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Mental disorder 250 trials · 7,390 incl. sub-types
14 sub-types
- Anxiety disorder 2,034 trials · 3,121 incl. sub-types Sub-types →
- Mood disorder 184 trials · 2,673 incl. sub-types Sub-types →
- Developmental disorder of mental health 1 trial · 1,590 incl. sub-types Sub-types →
- Psychotic disorder 201 trials · 769 incl. sub-types Sub-types →
- Pain agnosia 146 trials
- Psychosexual disorder 4 trials · 47 incl. sub-types Sub-types →
- Adjustment disorder 34 trials
- Disruptive behavior disorder 34 trials
- Alcohol-induced mental disorder 0 trials · 24 incl. sub-types Sub-types →
- Drug-induced mental disorder 1 trial · 8 incl. sub-types Sub-types →
- Visual agnosia 0 trials · 2 incl. sub-types Sub-types →
- Akinetopsia 0 trials
- Cortical deafness 0 trials
- Tactile agnosia 0 trials
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Cerebrovascular disorder 108 trials · 3,292 incl. sub-types
24 sub-types
- Stroke disorder 2,037 trials · 2,854 incl. sub-types Sub-types →
- Brain ischemia 55 trials · 283 incl. sub-types Sub-types →
- Intracranial arterial disease 26 trials · 206 incl. sub-types Sub-types →
- Brain infarction 26 trials · 151 incl. sub-types Sub-types →
- Carotid artery disorder 41 trials · 114 incl. sub-types Sub-types →
- Vascular dementia 72 trials Sub-types →
- Cerebral artery stenosis 23 trials · 71 incl. sub-types Sub-types →
- Occlusion precerebral artery 0 trials · 25 incl. sub-types Sub-types →
- Pseudotumor cerebri 22 trials
- Cerebral amyloid angiopathy 16 trials · 17 incl. sub-types Sub-types →
- Cerebral sinovenous thrombosis 16 trials
- Intracranial thrombosis 12 trials · 13 incl. sub-types Sub-types →
- Intracranial vasospasm 13 trials
- APP-related brain and vascular amyloidosis 0 trials · 5 incl. sub-types Sub-types →
- Basal ganglia cerebrovascular disorder 5 trials
- Internal carotid artery stenosis 5 trials
- Familial porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Vascular brain injury 3 trials
- HTRA1-related autosomal dominant cerebral small vessel disease 2 trials
- Subclavian steal syndrome 1 trial
- Cathepsin a-related arteriopathy-strokes-leukoencephalopathy 0 trials
- Cerebral arteritis 0 trials
- Microangiopathy and leukoencephalopathy, pontine, autosomal dominant 0 trials
- Precerebral artery stenosis 0 trials
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Basal ganglia disorder 9 trials · 1,322 incl. sub-types
4 sub-types
- Parkinsonian disorder 67 trials · 1,315 incl. sub-types Sub-types →
- Basal ganglia cerebrovascular disorder 5 trials
- Bilateral striopallidodentate calcinosis 1 trial Sub-types →
- Biotin-responsive basal ganglia disease 1 trial
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Brain neoplasm 247 trials · 1,080 incl. sub-types
17 sub-types
- Brain cancer 682 trials · 902 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 115 incl. sub-types Sub-types →
- Infratentorial neoplasm 6 trials · 115 incl. sub-types Sub-types →
- Brainstem neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Primary brain neoplasm 87 trials · 92 incl. sub-types Sub-types →
- Hypothalamic neoplasm 3 trials · 85 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Choroid plexus neoplasm 5 trials · 18 incl. sub-types Sub-types →
- Neoplasm of cerebral hemisphere 3 trials · 14 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cerebellopontine angle tumor 1 trial Sub-types →
- Dysembryoplastic neuroepithelial tumor 1 trial
- Childhood brain meningioma 0 trials
- Olfactory groove meningioma 0 trials
- Optic tract meningioma 0 trials Sub-types →
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Multiple sclerosis 770 trials · 858 incl. sub-types
4 sub-types
- Relapsing-remitting multiple sclerosis 265 trials
- Chronic progressive multiple sclerosis 83 trials · 115 incl. sub-types Sub-types →
- Pediatric multiple sclerosis 5 trials
- Marburg acute multiple sclerosis 0 trials
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Insomnia 823 trials · 827 incl. sub-types
1 sub-type
- Fatal familial insomnia 4 trials
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Cerebral cortex disorder 0 trials · 723 incl. sub-types
6 sub-types
- Cerebral palsy 443 trials · 499 incl. sub-types Sub-types →
- Visual cortex disorder 0 trials · 187 incl. sub-types Sub-types →
- Pick disease 35 trials
- Hippocampal sclerosis of aging 3 trials
- Occipital lobe neoplasm 0 trials
- Primary motor cortex epilepsy 0 trials
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Brain injury 220 trials · 693 incl. sub-types
2 sub-types
- Traumatic brain injury 559 trials
- Vascular brain injury 3 trials
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Epilepsy 461 trials · 645 incl. sub-types
13 sub-types
- Epilepsy syndrome 2 trials · 181 incl. sub-types Sub-types →
- Reflex epilepsy 1 trial · 155 incl. sub-types Sub-types →
- Focal epilepsy 101 trials · 135 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy 29 trials · 98 incl. sub-types Sub-types →
- Generalized epilepsy 9 trials · 39 incl. sub-types Sub-types →
- Monogenic epilepsy 0 trials · 12 incl. sub-types Sub-types →
- Metabolic epilepsy 0 trials · 8 incl. sub-types Sub-types →
- Post-traumatic epilepsy 6 trials
- Structural epilepsy 5 trials
- Immune epilepsy 0 trials · 1 incl. sub-types Sub-types →
- Infantile-onset epilepsy 1 trial Sub-types →
- Epilepsy, unknown whether focal or generalized 0 trials
- Extratemporal epilepsy 0 trials
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Migraine disorder 393 trials · 414 incl. sub-types
2 sub-types
- Migraine with aura 30 trials · 44 incl. sub-types Sub-types →
- Migraine without aura 42 trials
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Cerebellar disorder 9 trials · 271 incl. sub-types
5 sub-types
- Cerebellar degeneration 6 trials · 150 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 115 incl. sub-types Sub-types →
- Dandy-Walker syndrome 1 trial Sub-types →
- Behrens Baumann dust syndrome 0 trials
- Miller Fisher syndrome 0 trials
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Visual pathway disorder 1 trial · 201 incl. sub-types
5 sub-types
- Visual cortex disorder 0 trials · 187 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Coloboma of optic nerve 1 trial Sub-types →
- Retinal nerve fiber layer disorder 1 trial Sub-types →
- Optic tract meningioma 0 trials Sub-types →
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Pituitary gland disorder 18 trials · 175 incl. sub-types
9 sub-types
- Pituitary tumor 23 trials · 83 incl. sub-types Sub-types →
- Anterior pituitary gland disorder 1 trial · 60 incl. sub-types Sub-types →
- Hypopituitarism 5 trials · 46 incl. sub-types Sub-types →
- Neurohypophyseal diabetes insipidus 9 trials
- Inappropriate ADH syndrome 5 trials
- Hypophysitis 2 trials Sub-types →
- Necrosis of pituitary 0 trials · 1 incl. sub-types Sub-types →
- Empty sella syndrome 0 trials
- Pituitary hypoplasia 0 trials
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Thalamic disorder 0 trials · 110 incl. sub-types
3 sub-types
- Hypothalamic disorder 3 trials · 88 incl. sub-types Sub-types →
- Thalamic cancer 1 trial · 24 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
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Intracranial hypertension 51 trials · 97 incl. sub-types
2 sub-types
- Hypertensive encephalopathy 1 trial · 28 incl. sub-types Sub-types →
- Pseudotumor cerebri 22 trials
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Encephalitis 26 trials · 96 incl. sub-types
7 sub-types
- Infectious encephalitis 3 trials · 50 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Anti-NMDA receptor encephalitis 9 trials
- Meningoencephalitis 6 trials
- Limbic encephalitis 1 trial · 2 incl. sub-types Sub-types →
- Paraneoplastic isolated brainstem encephalitis 0 trials
- Post-vaccinal encephalitis 0 trials
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Hydrocephalus 52 trials · 79 incl. sub-types
7 sub-types
- Communicating hydrocephalus 3 trials · 38 incl. sub-types Sub-types →
- Obstructive hydrocephalus 6 trials
- Congenital hydrocephalus 1 trial · 3 incl. sub-types Sub-types →
- Baker Vinters syndrome 0 trials
- Craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome 0 trials
- Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome 0 trials Sub-types →
- Palmer pagon syndrome 0 trials
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Cerebral degeneration 0 trials · 61 incl. sub-types
2 sub-types
- Pick disease 35 trials
- Corticobasal degeneration disorder 28 trials
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Hepatic encephalopathy 45 trials
1 sub-type
- Hepatic coma 0 trials
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Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types
3 sub-types
- Narcolepsy 1 5 trials
- Narcolepsy 3 0 trials
- Narcolepsy 7 0 trials
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Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types
8 sub-types
- Sandhoff disease 13 trials Sub-types →
- Tay-Sachs disease 13 trials Sub-types →
- Gaucher disease type I 12 trials
- Cerebrotendinous xanthomatosis 6 trials
- Juvenile neuronal ceroid lipofuscinosis 6 trials Sub-types →
- Adult Krabbe disease 0 trials
- Adult neuronal ceroid lipofuscinosis 0 trials Sub-types →
- Infantile neuronal ceroid lipofuscinosis 0 trials Sub-types →
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Intracranial hypotension 32 trials
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Cluster headache syndrome 26 trials
1 sub-type
- Cluster headache, familial 0 trials
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Brain edema 23 trials
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Narcolepsy without cataplexy 22 trials
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Encephalomalacia 1 trial · 13 incl. sub-types
1 sub-type
- Periventricular leukomalacia 12 trials
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Olfactory nerve disorder 8 trials · 12 incl. sub-types
1 sub-type
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
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Traumatic encephalopathy 11 trials
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Prion disease 5 trials · 11 incl. sub-types
10 sub-types
- Creutzfeldt Jacob disease 4 trials · 7 incl. sub-types Sub-types →
- Fatal familial insomnia 4 trials
- Gerstmann-Straussler-Scheinker syndrome 1 trial
- Huntington disease-like 1 0 trials
- PrP systemic amyloidosis 0 trials
- Familial Alzheimer-like prion disease 0 trials
- Kuru 0 trials
- Scrapie 0 trials
- Spongiform encephalopathy with neuropsychiatric features 0 trials
- Sporadic fatal insomnia 0 trials
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Cerebral cortical dysplasia 2 trials · 7 incl. sub-types
2 sub-types
- Isolated focal cortical dysplasia 5 trials · 6 incl. sub-types Sub-types →
- Central bilateral macrogyria 0 trials
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Progressive bulbar palsy 5 trials
1 sub-type
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Akinetic mutism 3 trials
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Bilirubin encephalopathy 3 trials
1 sub-type
- Kernicterus due to isoimmunization 0 trials
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Central nervous system cyst 3 trials
1 sub-type
- Choroid plexus cyst 0 trials
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Megalencephaly 3 trials
4 sub-types
- Bagatelle Cassidy syndrome 0 trials
- Isolated megalencephaly 0 trials
- Macrocephaly/megalencephaly syndrome, autosomal recessive 0 trials
- Megalencephaly, autosomal dominant 0 trials
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Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types
1 sub-type
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Encephaloclastic disorder 0 trials · 3 incl. sub-types
3 sub-types
- Porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Hydranencephaly 0 trials Sub-types →
- Schizencephaly 0 trials Sub-types →
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Cerebral malaria 2 trials
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Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types
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Wernicke encephalopathy 1 trial
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Brain compression 1 trial
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Cerebral sarcoidosis 1 trial
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Reye syndrome 0 trials
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XK aprosencephaly 0 trials
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Acute bilirubin encephalopathy 0 trials
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Aprosencephaly 0 trials
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Atelencephaly 0 trials
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Bulbar polio 0 trials
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Cerebritis 0 trials
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Chronic bilirubin encephalopathy 0 trials
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Colpocephaly 0 trials
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12 sub-types
- Complex cortical dysplasia with other brain malformations 1 0 trials
- Complex cortical dysplasia with other brain malformations 2 0 trials
- Complex cortical dysplasia with other brain malformations 3 0 trials
- Complex cortical dysplasia with other brain malformations 4 0 trials
- Complex cortical dysplasia with other brain malformations 5 0 trials
- Complex cortical dysplasia with other brain malformations 6 0 trials
- Complex cortical dysplasia with other brain malformations 7 0 trials
- Cortical dysplasia, complex, with other brain malformations 10 0 trials
- Cortical dysplasia, complex, with other brain malformations 11 0 trials
- Cortical dysplasia, complex, with other brain malformations 12 0 trials
- Cortical dysplasia, complex, with other brain malformations 9 0 trials
- Polymicrogyria with optic nerve hypoplasia 0 trials
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Diabetic encephalopathy 0 trials
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Disorder of optic chiasm 0 trials
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Encephalopathy, acute transient 0 trials
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Glycine encephalopathy 0 trials
5 sub-types
- Atypical glycine encephalopathy 0 trials
- Glycine encephalopathy 1 0 trials
- Glycine encephalopathy 2 0 trials
- Infantile glycine encephalopathy 0 trials
- Neonatal glycine encephalopathy 0 trials
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Meningoencephalocele 0 trials
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Midbrain disorder 0 trials
Most studied deeper sub-types
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New drug aims to slow Alzheimer's in early stages
Disease control Stopped earlyThis study tests an experimental drug called GSK4527226 in 367 people with early Alzheimer's (mild memory problems or mild dementia). Participants receive either a low dose, high dose, or placebo through an IV. The goal is to see if the drug can slow down declines in memory and d…
Phase 2 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Alzheimer's drug trial halted early: what happened?
Disease control Stopped earlyThis early-stage study tested a new drug, ADEL-Y01, in healthy volunteers and people with mild Alzheimer's or mild cognitive impairment. The goal was to check safety and how the drug moves through the body. The trial was stopped early, so results are limited.
Phase 1 • Sponsor: Alzheimer's Disease Expert Lab (ADEL), Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Alzheimer's drug extension trial halted early — what we know
Disease control Stopped earlyThis study gave Alzheimer's patients who had already completed earlier XPro1595 trials an extra 55 to 74 weeks of the drug to check long-term safety and effects on memory and brain health. Only 11 people took part, and the trial was terminated early, so the findings are limited. …
Phase 2 • Sponsor: Inmune Bio, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Early trial of experimental cancer drug halted; data still under review
Disease control Stopped earlyThis early-phase study tested a new drug called PF-07284890, alone or with another drug (binimetinib), in 65 people with advanced cancers that have a specific genetic change (BRAF V600 mutation), including cancers that spread to the brain. The trial was terminated early, but rese…
Phase 1 • Sponsor: Pfizer • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Tiny brain scanner takes on the big machine
Diagnosis Stopped earlyResearchers are testing NeuroLF, a small brain-only PET scanner, to see if it can produce brain images good enough for diagnosis. Participants who are already scheduled for a routine brain PET scan receive an extra scan on NeuroLF right after their standard scan, using the same r…
Sponsor: Positrigo AG • Aim: Diagnosis
Last updated Sep 20, 2026 00:00 UTC
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New brain scanner peers into COVID's neurological mysteries
Knowledge-focused Stopped earlyThis pilot study tested a new brain PET-MR scanner to see if it can capture clear images of brain metabolism and blood flow in people who had COVID-19 and those who did not. Only 3 participants were enrolled before the study ended early. The goal was to develop an imaging protoco…
Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC