Bone development disease
MONDO:0005497A disease involving the bone development.
Also known as: bone development disease, bone development disease or disorder, disease of bone development, disease or disorder of bone development, disorder of bone development
527 clinical trials for this condition and its sub-types, 2 tagged with Bone development disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Bone development disease
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Osteochondrodysplasia 12 trials · 380 incl. sub-types
50 sub-types
- Osteogenesis imperfecta 35 trials · 329 incl. sub-types Sub-types →
- Achondroplasia 26 trials
- Hypochondroplasia 9 trials
- Spondyloepiphyseal dysplasia 0 trials · 8 incl. sub-types Sub-types →
- Spondyloepimetaphyseal dysplasia 0 trials · 4 incl. sub-types Sub-types →
- Blount disease 2 trials Sub-types →
- Diastrophic dysplasia 2 trials
- Mesomelic dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Neonatal osteosclerotic dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Cleidocranial dysplasia 1 1 trial
- Metaphyseal chondrodysplasia, Jansen type 1 trial
- Microcephalic osteodysplastic primordial dwarfism type I 1 trial
- Microcephalic osteodysplastic primordial dwarfism type II 1 trial
- Midface dysplasia 1 trial
- Pseudoachondroplasia 1 trial
- Akaba Hayasaka syndrome 0 trials
- Boomerang dysplasia 0 trials
- Desbuquois dysplasia 0 trials Sub-types →
- Fairbank disease 0 trials
- Kashin-Beck disease 0 trials
- Kniest dysplasia 0 trials
- Leri-Weill dyschondrosteosis 0 trials Sub-types →
- Pyle disease 0 trials Sub-types →
- Schmid metaphyseal chondrodysplasia 0 trials
- Acheiropody 0 trials
- Achondrogenesis 0 trials Sub-types →
- Acrocapitofemoral dysplasia 0 trials
- Acromesomelic dysplasia 0 trials Sub-types →
- Arterial tortuosity-bone fragility syndrome 0 trials
- Atelosteogenesis 0 trials Sub-types →
- Bone dysplasia, lethal Holmgren type 0 trials
- Brachyolmia 0 trials Sub-types →
- Campomelic dysplasia 0 trials
- Cleidocranial dysplasia 2 0 trials
- Cleidocranial dysplasia, recessive form 0 trials
- Fibrochondrogenesis 0 trials Sub-types →
- Hypertrichotic osteochondrodysplasia Cantu type 0 trials
- Lethal Kniest-like dysplasia 0 trials
- Lethal chondrodysplasia, Seller type 0 trials
- Linkeropathy 0 trials Sub-types →
- Mesomelia-synostoses syndrome 0 trials
- Metaphyseal chondrodysplasia, Kaitila type 0 trials
- Metaphyseal chondrodysplasia, Spahr type 0 trials
- Metaphyseal chondrodysplasia-retinitis pigmentosa syndrome 0 trials
- Multiple epiphyseal dysplasia 0 trials Sub-types →
- Pycnodysostosis 0 trials
- Pyknoachondrogenesis 0 trials
- Schneckenbecken dysplasia 0 trials
- Thanatophoric dysplasia 0 trials Sub-types →
- Ulna metaphyseal dysplasia syndrome 0 trials
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Dysostosis 0 trials · 85 incl. sub-types
108 sub-types
- Synostosis 1 trial · 40 incl. sub-types Sub-types →
- Amniotic band syndrome 8 trials · 9 incl. sub-types Sub-types →
- Spondylocostal dysostosis 5 trials · 8 incl. sub-types Sub-types →
- Non-syndromic amelia 1 trial · 5 incl. sub-types Sub-types →
- Oculoauriculovertebral spectrum with radial defects 0 trials · 5 incl. sub-types Sub-types →
- Rubinstein-Taybi syndrome 3 trials Sub-types →
- Acheiria 0 trials · 2 incl. sub-types Sub-types →
- Congenital absence of both forearm and hand 1 trial · 2 incl. sub-types Sub-types →
- Congenital pseudoarthrosis of the limbs 1 trial · 2 incl. sub-types Sub-types →
- Hemimelia 0 trials · 2 incl. sub-types Sub-types →
- Nail-patella syndrome 2 trials
- Currarino triad 1 trial
- Duane-radial ray syndrome 1 trial Sub-types →
- EEC syndrome 1 trial Sub-types →
- Acrofacial dysostosis 0 trials · 1 incl. sub-types Sub-types →
- Femoral agenesis/hypoplasia 1 trial Sub-types →
- Femur-fibula-ulna complex 1 trial
- Frontonasal dysplasia 1 trial Sub-types →
- Split hand-foot malformation 0 trials · 1 incl. sub-types Sub-types →
- Thalidomide embryopathy 1 trial
- Thrombocytopenia-absent radius syndrome 1 trial
- Trigonocephaly 1 trial Sub-types →
- ADULT syndrome 0 trials
- Adams-Oliver syndrome 0 trials Sub-types →
- Aphalangy-hemivertebrae-urogenital-intestinal dysgenesis syndrome 0 trials
- Cooks syndrome 0 trials
- EEM syndrome 0 trials
- Fuhrmann syndrome 0 trials
- Gollop-Wolfgang complex 0 trials
- IVIC syndrome 0 trials
- Karsch-Neugebauer syndrome 0 trials
- Melhem-Fahl syndrome 0 trials
- Prata-Liberal-Goncalves syndrome 0 trials
- Absence deformity of leg-cataract syndrome 0 trials
- Absent radius-anogenital anomalies syndrome 0 trials
- Absent tibia-polydactyly-arachnoid cyst syndrome 0 trials
- Acromesomelic dysplasia 2B 0 trials
- Adactylia, unilateral 0 trials
- Adactyly of foot 0 trials Sub-types →
- Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome 0 trials Sub-types →
- Aphalangy-syndactyly-microcephaly syndrome 0 trials
- Apodia 0 trials Sub-types →
- Autosomal recessive amelia 0 trials
- Bipartite talus 0 trials
- Brachydactyly-arterial hypertension syndrome 0 trials
- Brachytelephalangy-dysmorphism-Kallmann syndrome 0 trials
- Camptodactyly syndrome, Guadalajara type 2 0 trials
- Camptodactyly syndrome, Guadalajara type 3 0 trials
- Camptodactyly with fibrous tissue hyperplasia and skeletal dysplasia 0 trials
- Camptodactyly, myopia, and fibrosis of the medial rectus muscle of eye 0 trials
- Congenital absence of both lower leg and foot 0 trials Sub-types →
- Congenital absence of thigh and lower leg with foot present 0 trials Sub-types →
- Congenital absence of upper arm and forearm with hand present 0 trials
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome 0 trials
- Congenital pseudoarthrosis of clavicle 0 trials
- Dysostosis multiplex, Ain-Naz type 0 trials
- External auditory canal atresia-vertical talus-hypertelorism syndrome 0 trials
- Femoral-facial syndrome 0 trials
- Fibular aplasia, tibial campomelia, and oligosyndactyly syndrome 0 trials
- Fibular aplasia-ectrodactyly syndrome 0 trials
- Genitopatellar syndrome 0 trials
- Hand-foot-genital syndrome 0 trials
- Heart-hand syndrome 0 trials Sub-types →
- Hereditary thrombocytosis with transverse limb defect 0 trials
- Humerus trochlea aplasia 0 trials
- Hyperphalangy 0 trials Sub-types →
- Imperforate oropharynx-costo vetebral anomalies syndrome 0 trials
- Intellectual disability-brachydactyly-Pierre Robin syndrome 0 trials
- Intellectual disability-spasticity-ectrodactyly syndrome 0 trials
- Ischio-vertebral syndrome 0 trials
- Lethal faciocardiomelic dysplasia 0 trials
- Limb transversal defect-cardiac anomaly syndrome 0 trials
- Mammary-digital-nail syndrome 0 trials
- Mandibulofacial dysostosis 0 trials Sub-types →
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-hip dysplasia syndrome 0 trials Sub-types →
- Oculomaxillofacial dysostosis 0 trials Sub-types →
- Omphalocele-diaphragmatic hernia-cardiovascular anomalies-radial ray defect syndrome 0 trials
- Oromandibular-limb anomalies syndrome 0 trials Sub-types →
- Otoonychoperoneal syndrome 0 trials
- Patella aplasia/hypoplasia 0 trials Sub-types →
- Pelvic dysplasia-arthrogryposis of lower limbs syndrome 0 trials
- Pelvis-shoulder dysplasia 0 trials
- Pelviscapular dysplasia 0 trials
- Phocomelia, Schinzel type 0 trials
- Phocomelia-ectrodactyly-deafness-sinus arrhythmia syndrome 0 trials
- Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome 0 trials
- Postaxial tetramelic oligodactyly 0 trials
- Preaxial digit brachydactyly-webbed fingers 0 trials
- Progressive non-infectious anterior vertebral fusion 0 trials
- Proximal femoral focal deficiency 0 trials
- Radial deficiency-tibial hypoplasia syndrome 0 trials
- Radio-renal syndrome 0 trials
- Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome 0 trials Sub-types →
- Rapadilino syndrome 0 trials
- Shoulder and thorax deformity-congenital heart disease syndrome 0 trials
- Splenogonadal fusion-limb defects-micrognathia syndrome 0 trials
- Split foot 0 trials Sub-types →
- Split hand 0 trials Sub-types →
- Split hand-foot malformation 1 with sensorineural hearing loss 0 trials
- Split-foot malformation-mesoaxial polydactyly syndrome 0 trials
- Spondylocostal dysostosis-anal and genitourinary malformations syndrome 0 trials
- Syngnathia multiple anomalies 0 trials
- Tetraamelia-multiple malformations syndrome 0 trials Sub-types →
- Tetramelic monodactyly 0 trials
- Tibia, hypoplasia or aplasia of, with polydactyly 0 trials
- Tibial aplasia-ectrodactyly syndrome 0 trials Sub-types →
- Ulna hypoplasia-intellectual disability syndrome 0 trials
- Ulnar hypoplasia-split foot syndrome 0 trials
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Developmental dysplasia of the hip 62 trials
4 sub-types
- Developmental dysplasia of the hip 1 5 trials
- Developmental dysplasia of the hip 2 0 trials
- Developmental dysplasia of the hip 3 0 trials
- Developmental dysplasia of the hip 4 0 trials
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Angioosteohypotrophic syndrome 0 trials
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Odontoid hypoplasia 0 trials
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Segmental odontomaxillary dysplasia 0 trials
Most studied deeper sub-types
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Can a new hip implant stand the test of time?
Disease control Stopped earlyThis study follows about 300 people who receive a hip replacement using the GTS cementless stem, a type of implant that anchors to bone without cement. The goal is to see how well the implant performs over up to 10 years, measuring pain, function, and joint stability. Participant…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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A common supplement may shield bones in kidney disease — a trial puts it to the test
Disease control Stopped earlyThis pilot trial investigates whether potassium citrate can improve bone quality and strength in adults and children with chronic kidney disease. Participants take either potassium citrate or a placebo for six months, along with blood and urine tests and advanced bone scans. The …
Phase 2/3 • Sponsor: Albert Einstein College of Medicine • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Experimental achondroplasia drug trial halted early
Disease control Stopped earlyThis study tested an experimental drug called SAR442501 in children with achondroplasia, a common form of dwarfism. The goal was to see if the drug was safe and could improve growth. However, the trial was stopped early after enrolling only 16 children, so we have very little inf…
Phase 2 • Sponsor: Sanofi • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Could a common cholesterol drug protect bones and hearts after spinal injury?
Disease control Stopped earlyThis study tested whether the statin drug rosuvastatin, taken daily with supplements, could improve bone density and reduce heart disease risk in adults with long-term spinal cord injury. Only 8 people enrolled before the trial was stopped early. Participants received either rosu…
Phase 2 • Sponsor: Dr. B. Catharine. Craven • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Bladder cancer drug combo study halted early
Disease control Stopped earlyThis study looked at whether adding an immunotherapy drug (pembrolizumab) to a targeted therapy (pemigatinib) works better than the targeted therapy alone or standard care for people with advanced bladder cancer that has a specific gene change (FGFR3). The study was stopped early…
Phase 2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Targeted drug pemigatinib tested in tumors with FGFR mutations – trial stopped early
Disease control Stopped earlyThis phase 2 study tested the drug pemigatinib in 111 people with advanced solid tumors that have specific FGFR gene mutations or translocations. The goal was to see if the drug could shrink tumors. The trial was terminated early, so the full results are not available.
Phase 2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Experimental cancer drug INCB062079 tested in early trial
Disease control Stopped earlyThis early-phase trial tested a new drug called INCB062079 in 25 people with advanced liver cancer and other solid tumors. The main goal was to check safety and find the best dose. The study was terminated early, so results are limited.
Phase 1 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Tiny trial compares skull surgery techniques for babies
Disease control Stopped earlyThis study compared two ways of doing endoscopic strip craniectomy (a keyhole surgery to remove a fused skull seam) in infants under 6 months with sagittal craniosynostosis. The goal was to see which method leads to better head shape and fewer complications. Only 6 babies were en…
Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 26, 2026 19:07 UTC
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Experimental drug for brittle bones tested in small trial
Disease control Stopped earlyThis early-stage trial tested a single dose of a drug called SAR439459 in 16 adults with osteogenesis imperfecta (brittle bone disease). The drug aims to block a protein that may weaken bones. The study focused on safety and how the drug moves through the body, but it was termina…
Phase 1 • Sponsor: Sanofi • Aim: Disease control
Last updated Jun 26, 2026 16:39 UTC
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Scientists dive into rare cholesterol disorders to uncover clues
Knowledge-focused Stopped earlyThis study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Brain scans reveal how skull surgery affects young Children's neural pathways
Knowledge-focused Stopped earlyThis study looked at how craniosynostosis—a condition where a baby's skull bones fuse too early—affects brain development. Researchers used special MRI scans and developmental tests to compare children with the condition before and after skull surgery to healthy children of the s…
Sponsor: University of Arkansas • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Puberty blockers and bones: new study explores risks for transgender teens
Knowledge-focused Stopped earlyThis study looked at bone health in transgender youth aged 9-14 who were starting puberty blockers (GnRH agonists). Researchers used MRI and other scans to measure bone marrow and density changes over 24 months, comparing them to healthy peers. The goal was to understand if block…
Sponsor: Amy DiVasta, MD • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Tiny study on nerve stimulation for pain halted early
Knowledge-focused Stopped earlyThis study looked at a type of spinal cord stimulation (SCS) that doesn't cause tingling, called paresthesia-free SCS, in 10 adults with chronic pain. Researchers wanted to see how well it works and how it affects pain perception. The study was terminated early, so the findings a…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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New hip implant put to the test: will it stay put?
Knowledge-focused Stopped earlyThis study looked at a specific hip implant shell (the Pinnacle Acetabular Shell) used in total hip replacement. Researchers wanted to see how much the implant moved (migrated) over two years using a special X-ray technique called RSA. They also tracked how patients felt and func…
Sponsor: DePuy Orthopaedics • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Elderly arthritis study reveals hidden health risks
Knowledge-focused Stopped earlyThis study aimed to understand how age influences serious health issues like infections, cancer, heart disease, and bone fractures in people with rheumatoid arthritis. Researchers compared patients over 65 with younger adults (18-50) who had the same disease. The study was stoppe…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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HIV drugs may weaken bones: new study investigates
Knowledge-focused Stopped earlyThis study looked at bone density in HIV-positive men to see if antiretroviral drugs cause bone thinning. Researchers compared men starting HIV treatment with those not yet on therapy over two years. The goal was to understand why bone loss is more common in HIV patients.
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC