Bilirubin metabolism disease

This expanded access program offers the experimental drug odevixibat to people with progressive familial intrahepatic cholestasis (PFIC) who have severe itching and high bile acid levels but cannot join the main clinical trial. The drug works by blocking a bile acid transporter i…

This study compares two ways of using phototherapy (light treatment) for jaundice in extremely premature infants (under 750 grams or 27 weeks gestation). One group gets continuous light, the other gets timed cycles based on bilirubin levels. The main goal is to see if cycled phot…

This study tests whether giving extremely preterm babies less intravenous (IV) fat (lipids) can lower harmful bilirubin levels and protect their brain development. Bilirubin can build up in these tiny infants and cause hearing loss or long-term disabilities. Researchers will comp…

This pilot study tests whether gently massaging a newborn's belly can help prevent jaundice, a common condition that causes yellowing of the skin. Researchers at UC Davis will enroll 30 healthy newborns and ask some parents to perform the massage. The main goal is to see if paren…

This study tests whether a special hat with built-in goggles can make phototherapy more comfortable for full-term newborns with jaundice, compared to standard eye patches. Researchers will measure the babies' comfort levels, bilirubin changes, treatment duration, and parental sat…

This study tests whether gentle acupressure on specific points can lower bilirubin levels in full-term newborns with jaundice. Sixty babies will be randomly assigned to receive acupressure or standard care. The goal is to see if this simple, non-invasive technique can help reduce…

This study looks at a rare liver disease called PFIC, which causes severe itching and liver damage. Researchers compare patients who took the drug odevixibat to those who did not, using data from past studies and a patient registry. The goal is to see if odevixibat helps avoid li…

This study followed children and young adults with genetic liver diseases that cause bile buildup. The goal was to track how these diseases progress over time, including the need for liver transplants or other complications. No treatments were tested; the aim was simply to learn …

This study tests a new wireless sensor that continuously measures the light dose babies receive during phototherapy for jaundice. Currently, doctors check light levels only once a day with a handheld device, which can be inaccurate. The sensor aims to provide real-time data to en…