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Progressive familial intrahepatic cholestasis type 2
MONDO:0011156Progressive familial intrahepatic cholestasis type 2 (PFIC2), a type of progressive familial intrahepatic cholestasis (PFIC), is a severe, neonatal, hereditary disorder in bile formation that is hepatocellular in origin and not associated with extrahepatic features. Initially, PFIC2 was reported under the name Byler syndrome.
Also known as: ABCB11 progressive familial intrahepatic cholestasis, BSEP deficiency, PFIC2, cholestasis, progressive familial intrahepatic 2, cholestasis, progressive familial intrahepatic, type 2, progressive familial intrahepatic cholestasis caused by mutation in ABCB11, progressive familial intrahepatic cholestasis type 2, cholestasis, progressive familial intrahepatic, 2
11 clinical trials for this condition and its sub-types, 4 tagged with Progressive familial intrahepatic cholestasis type 2 itself.
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New study aims to make bile duct drainage safer
Symptom relief Recruiting nowThis study tests two methods for widening a blocked bile duct during a special endoscopy procedure. One method uses a mechanical dilator, the other uses an electrocautery device. The goal is to see which causes less bleeding. The trial will involve 64 patients who cannot have sta…
Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Bile duct battle: which backup technique works best?
Knowledge-focused Recruiting nowThis study compares two advanced techniques used when doctors have trouble reaching the bile duct during a procedure called ERCP. About 188 adults with difficult bile duct access will be randomly assigned to either an endoscopic ultrasound-guided rendezvous technique or an early …
Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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New national registry aims to unlock secrets of rare childhood liver diseases
Knowledge-focused Recruiting nowThis study creates a Canadian registry for children under 18 with Alagille syndrome or genetic intrahepatic cholestasis, rare liver conditions that cause bile buildup. Researchers will collect health data from medical records over time to understand how these diseases progress an…
Sponsor: Children's Hospital of Eastern Ontario • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Gene hunt for mysterious adult liver disease
Knowledge-focused Recruiting nowThis study is using advanced whole-genome sequencing to find hidden genetic causes of cholestatic liver disease in adults whose condition remains unexplained after standard tests. Researchers will compare the DNA of 60 affected adults to a large group of healthy controls. The goa…
Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Albumin recovery time may forecast surgical outcomes
Knowledge-focused Recruiting nowThis study tracks 1,000 patients undergoing major liver, pancreas, or bile duct surgery to see if the time it takes for their albumin levels to return to normal can predict complications and length of hospital stay. Albumin is a protein that drops after surgery due to inflammatio…
Sponsor: Institute of Liver and Biliary Sciences, India • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC