Basal cell carcinoma

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers are testing the drug cemiplimab, given alone or with other anti-cancer drugs, in people with locally advanced basal cell carcinoma that cannot be treated with surgery or radiation. The trial compares how well the combinations work against cemiplimab by itself and trac…

This trial tests whether a new skin graft substitute (CAMP) plus standard wound care helps wounds heal faster after Mohs surgery for skin cancer compared to standard care alone. About 160 adults who have had Mohs surgery for a skin cancer will be randomly assigned to receive eith…

This study tests a new type of radiation called FLASH therapy, which delivers the entire dose in milliseconds instead of minutes. The goal is to see if it can treat skin cancers (squamous cell and basal cell carcinomas) just as well as standard radiation but with fewer side effec…

This study tests whether high intensity focused ultrasound (HIFU) works as well as standard cryotherapy (freezing) for treating low-risk basal cell carcinomas and Bowen's disease. About 294 adults with small skin cancers on their body (not face or hands) will be randomly assigned…

This study asks whether an artificial intelligence algorithm can accurately identify basal cell carcinoma, a common type of skin cancer, from digitized tissue samples. Researchers will compare the AI's diagnostic performance—its sensitivity and specificity—against the assessments…

This study tests whether an AI-powered imaging tool can accurately detect the edges of common skin cancers before surgery. Researchers will compare AI-OCT scans with standard surgical results in 30 adults with basal cell carcinoma. If the AI works well, it could help surgeons rem…

This study tests whether a special camera (LC-OCT) can help surgeons remove basal cell carcinoma more efficiently. About 290 adults with skin cancer will be randomly assigned to standard surgery or surgery guided by this imaging tool. The goal is to see if the camera reduces the …

This Phase 3 trial tests whether a daily imiquimod cream applied to the face for 12 weeks can prevent new basal cell carcinomas (BCC) in 1,630 veterans at high risk. Participants apply either the active cream or a placebo and are followed for up to 3 years with skin exams. The go…

This trial tests whether injecting Botox (abobotulinumtoxin-A) into the forehead muscles just before paramedian forehead flap surgery can improve the cosmetic appearance of the resulting scar. Adults with nasal skin cancer defects needing this reconstruction are randomly assigned…

This study will show 20 cases of basal cell carcinoma (the most common skin cancer) to doctors from different specialties—dermatologists, oncologists, surgeons, and radiation therapists—to see how they classify and treat the same cases. The goal is to understand why there is so m…

This study tests a non-invasive imaging technique called LC-OCT for diagnosing basal cell carcinoma, the most common skin cancer. Researchers will review medical records of about 300 patients to see if LC-OCT can accurately detect cancer and guide treatment without needing a biop…

This study looks at whether using a high-frequency ultrasound before surgery for common skin cancers on the head and neck can help surgeons remove the entire tumor the first time. About 400 adults with basal or squamous cell skin cancer will be in the study. Some will get the sta…