Avascular necrosis
MONDO:0018373Necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.
Also known as: AVN, avascular necrosis of bone
141 clinical trials for this condition and its sub-types, 80 tagged with Avascular necrosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Avascular necrosis
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Primary avascular necrosis 0 trials · 39 incl. sub-types
3 sub-types
- Familial avascular necrosis of femoral head 20 trials · 39 incl. sub-types Sub-types →
- Idiopathic avascular necrosis 1 trial
- Pseudohypoparathyroidism type 1C 0 trials
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Secondary avascular necrosis 1 trial · 38 incl. sub-types
6 sub-types
- Osteonecrosis of the jaw 21 trials
- Gaucher disease type I 12 trials
- Hereditary antithrombin deficiency 3 trials
- Secondary non-traumatic avascular necrosis 1 trial
- Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency 0 trials
- Traumatic avascular necrosis 0 trials
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Dysbaric osteonecrosis 0 trials
Most studied deeper sub-types
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Can a new plastic hip liner outlast the old ones?
Disease control CompletedThis study tracks 245 adults aged 18 to 60 who receive a Vivacit-E liner during hip replacement surgery. The liner is a plastic cup that fits inside the hip socket to allow smooth movement. Researchers measure how long the liner stays in place without needing removal, and they ch…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Can a less invasive hip surgery speed up recovery?
Disease control CompletedThis trial compares two surgical approaches for total hip replacement: the minimally invasive SuperPATH technique and the conventional posterior approach. Adults with hip arthritis or related conditions are randomly assigned to one of the two procedures. The study tracks recovery…
Phase 4 • Sponsor: Dr. Gavin Wood • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New Stem-Free shoulder implant shows promise in european study
Disease control CompletedThis study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Which artificial knee feels most natural? study pits four designs Head-to-Head
Disease control CompletedThis study compared four different knee replacement devices in 218 adults with knee arthritis to see which one patients 'forget' about most after surgery. The main goal was to measure how natural the joint feels using the Forgotten Joint Score. Results could help surgeons choose …
Sponsor: David F. Scott, MD • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Bone filler injection in hip shows promise for pain relief
Disease control CompletedThis study followed 77 people who had a procedure called Subchondroplasty for hip bone defects. Doctors injected a calcium phosphate bone filler into the damaged area. The goal was to see if it improved pain, movement, and daily activities over two years. Results were measured us…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New shoulder implant shows promise in early study
Disease control CompletedThis study tested a new shoulder implant called the Catalyst CSR System in 87 people with shoulder arthritis or bone damage. The implant is designed to preserve more natural bone than traditional replacements. Researchers measured pain, movement, and implant safety over two years…
Sponsor: Catalyst OrthoScience • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Can a sprinkle of powder and a wash stop joint infections?
Disease control CompletedThis study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. T…
Phase 1 • Sponsor: NYU Langone Health • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Hip implant passes 10-Year test
Disease control CompletedThis study looked at how well a specific hip replacement system (the Allofit IT Shell with Longevity Liners) works over 10 years. 197 people with hip problems like arthritis or bone death received the implant. The main goal was to see how many implants were still in place without…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Robot-Assisted knee surgery shows promise in alignment study
Disease control CompletedThis study tested a robotic system called CORI that helps surgeons plan and perform knee replacement surgery. The goal was to see if the robot helps place the new knee joint more accurately. 126 adults who needed a partial or total knee replacement took part. The results showed t…
Sponsor: Smith & Nephew, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New knee implant helps patients forget they have a fake joint
Disease control CompletedThis study looked at how well a specific knee replacement, the Medacta GMK Sphere, works over time. Researchers measured how often patients forgot about their artificial knee in daily life, two and five years after surgery. The study involved 260 adults with osteoarthritis who ne…
Sponsor: Medacta USA • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New shoulder implant MIRAI put to the test in 76 patients
Disease control CompletedThis study followed 76 adults who received a total shoulder replacement using the MIRAI modular prosthesis. Researchers measured how well the shoulder functioned and how stable the implant was over five years. The goal was to see if the implant helps patients move better and last…
Sponsor: Permedica spa • Aim: Disease control
Last updated Jun 26, 2026 12:51 UTC
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Could a nasal spray shield aging brains from Post-Surgery confusion?
Prevention CompletedThis trial tests whether oxytocin nasal spray can prevent postoperative delirium—a state of confusion that can occur after surgery—in older adults undergoing orthopedic procedures. Participants aged 65 and older will receive the spray before the end of anesthesia and twice daily …
Phase 2 • Sponsor: Zhejiang University • Aim: Prevention
Last updated Aug 22, 2026 00:00 UTC
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New knee tensioner aims to improve replacement outcomes
Symptom relief CompletedThis study is testing a device called the CORI™ KNEE TENSIONER, which helps surgeons balance the knee during total knee replacement surgery. Fifty adults who need a knee replacement will have the surgery using this device, and their recovery and quality of life will be tracked fo…
Sponsor: Smith & Nephew, Inc. • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Scientists examine bone tissue to uncover causes of hip joint decay
Knowledge-focused CompletedThis study looked at bone tissue from 34 men who had hip replacement surgery due to femoral head necrosis (bone death in the hip joint). Researchers used advanced imaging and spectroscopy to identify changes in bone structure and composition. The goal was to better understand wha…
Sponsor: Lille Catholic University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:10 UTC
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Hip implant performance under review in completed study
Knowledge-focused CompletedThis study looked back at 54 people who had a hip replacement with a specific part called the CL TRAUMA cemented stem. The goal was to see if the part was safe and worked well. Researchers measured how well patients could move and if they had pain using a standard hip score.
Sponsor: Limacorporate S.p.a • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Hip implant performance tracked in 162 patients
Knowledge-focused CompletedThis study followed 162 people who received a G7 hip cup system during hip replacement surgery. Researchers measured pain, function, and hip movement using standard scores. The goal was to see how the device performs in everyday patients with arthritis or other joint problems.
Sponsor: Zimmer Biomet • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Hip troubles: new study reveals how they change your posture and balance
Knowledge-focused CompletedThis study looked at 110 adults with different hip problems, such as arthritis or labral tears, to understand how these conditions affect posture, muscle strength, balance, pain, and quality of life. Researchers used special 3D imaging and pain tests to measure these factors. The…
Sponsor: Hacettepe University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Hip implant showdown: which stem saves more bone?
Knowledge-focused CompletedThis study looked at 40 people who had a total hip replacement through a small incision in the front of the hip. Researchers compared two types of metal stems (AMIStem and Quadra) to see how bone density around the implant changed one year after surgery. The goal was to find out …
Sponsor: Medacta International SA • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC