Autonomic nervous system disorder

This study tests a procedure called cardioneuroablation for people with a slow heart rate (bradycardia) caused by overactive vagal nerves. Doctors use a catheter to ablate (destroy) specific nerve clusters in the heart. The trial will enroll 188 participants aged 18-65 and measur…

This study tests a new way to treat children with gut-brain disorders like cyclic vomiting and functional dyspepsia. The therapy uses a mild electrical nerve stimulation to the ear, personalized based on each child's nerve activity. The goal is to improve quality of life and redu…

This trial tests whether an injected tracer called HED, seen on PET/CT or MRI scans, can help diagnose diseases of the sympathetic nervous system, the part of the body that controls automatic responses like heart rate and blood pressure. Researchers will scan 500 adults who have …

This study tests whether Northera (droxidopa) is safe and can improve symptoms like dizziness, fainting, and low blood pressure in children aged 7 to 17 with Menkes disease. Six to ten participants will receive either the drug or a placebo in two four-week periods, with careful d…

This study tests whether a structured exercise program can improve heart rate variability (a measure of heart health), reduce menopausal symptoms, and enhance sleep and quality of life in postmenopausal women aged 45 to 65. Forty women will either join a supervised 12-week exerci…

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study is testing whether a small, battery-powered device worn on the ear can reduce gastrointestinal symptoms in children aged 10-18 with hypermobile Ehlers-Danlos syndrome (hEDS) and related autonomic nervous system problems. The device, called IB-Stim, delivers gentle elec…

This study tests whether special breathing exercises can help veterans and others with persistent post-concussion symptoms like headaches, dizziness, and memory trouble. The exercises aim to improve heart rate variability, a sign of how well the nervous system is working. 148 par…

This study tests a prescription wrist device called NightWare that detects when a veteran with PTSD is having a nightmare and gently disrupts it without waking them. Researchers want to see if better sleep from fewer nightmares can also improve blood vessel and heart health. 125 …

This study gathers medical information from 200 adults with possible nerve, muscle, or autonomic nervous system disorders who are not already in other NIH studies. Participants undergo standard tests like nerve conduction studies, EMG, and physical exams. The data is stored anony…

This study checks if a French version of the New Mobility Score (NMS) works well for older adults hospitalized after a hip fracture. The NMS is a simple test that measures how well a person can move indoors, outdoors, and while shopping. Researchers will test it with 100 patients…

This study looks at how blood pressure changes when standing affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants, with and without orthostatic hypotension (low blood pressure on standing), will take thinking tests while lying down and st…

This study looks at how the body's automatic systems control heart rate, blood pressure, and blood flow to the brain when a person stands up. Sixty healthy adults will have their heart activity, blood pressure, brain blood velocity, and breathing recorded while lying down and the…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study looks at whether raising carbon dioxide levels in the blood can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 levels in 26 adults with POTS during a tilt-tabl…

This study looks at how the autonomic nervous system (which controls automatic body functions) might be involved in liver cancer. Researchers will measure nerve activity and psychological traits in 100 adults with cirrhosis to find new ways to detect liver cancer earlier. The goa…

This study looks at whether doing jaw stretches and a specific breathing pattern (4-4-8) can affect stress levels, muscle tightness, and mood. About 52 healthy university students will be randomly assigned to do these exercises. Researchers will measure heart rate, blood pressure…

This study from the University of Florida is looking at how listening to calming music might affect your health and sense of calm. About 100 participants will listen to a 15-minute music session, fill out surveys, and some will also have their heart rate monitored and give saliva…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

This study looks at why people with COPD may have overactive nerve signals that increase heart rate and narrow blood vessels. Researchers will measure nerve activity, breathing, and inflammation in 135 adults with COPD. The goal is to better understand the causes, not to test a n…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at a mobile workshop called Breizh Fabribus that uses 3D printing and laser cutting to make custom assistive devices on the spot for people with disabilities in a region of France. Researchers will track 70 people who received a device to see if it helps them do …

This study looks at whether a blood test for a protein called p-tau181 and brain scans can predict which elderly patients with dementia, frailty, and loss of independence will need to visit the emergency room within six months. Researchers will follow 110 participants and track E…

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …