ALK-positive anaplastic large cell lymphoma

Researchers are testing an experimental drug called SY-12321 in adults with advanced cancers that carry an ALK gene change. These include non-small cell lung cancer, inflammatory myofibroblastic tumor, anaplastic large-cell lymphoma, colorectal cancer, pancreatic cancer, and brea…

This study tests a drug called repotrectinib in children and young adults (up to age 25) with advanced solid tumors, lymphoma, or brain tumors that have specific gene changes (ALK, ROS1, or NTRK1-3). The goal is to find the safest dose and see if the drug shrinks tumors. Particip…

This phase 3 study compares a new drug, NVL-655, to the standard treatment alectinib in people with advanced ALK-positive non-small cell lung cancer who have not had prior therapy. About 450 participants will be randomly assigned to receive either NVL-655 or alectinib. The main g…

This early-phase study tests gilteritinib, a drug already approved for a type of leukemia, in about 40 adults with ALK-positive non-small cell lung cancer whose tumors no longer respond to standard ALK inhibitors. Participants take gilteritinib tablets daily in 28-day cycles. The…

This early-phase trial tests a new approach for people with certain lymphomas that have come back or not responded to treatment. Researchers take immune cells from healthy donors, modify them to recognize and attack CD30-positive cancer cells, and add a molecule (C7R) to boost th…

This early-phase study tests a combination of two drugs, alectinib and duvelisib, in 30 people with a rare type of blood cancer called ALK-positive anaplastic large cell lymphoma that has come back or not responded to prior treatment. The goal is to find a safe dose and see if th…

This phase 2 trial tests a risk-adapted treatment for children, adolescents, and young adults with relapsed or refractory ALK-positive anaplastic large cell lymphoma. Participants receive nivolumab (an immunotherapy) combined with chemotherapy drugs like vinblastine or brentuxima…

This study tests whether the drug golidocitinib can help keep peripheral T-cell lymphoma (a rare blood cancer) from coming back after initial chemotherapy. About 136 adults who had a good response to first treatment but cannot or choose not to have a stem cell transplant will tak…

This study tests a drug called brigatinib in children and young adults (ages 1 to 25) with certain ALK-positive cancers, including anaplastic large cell lymphoma and inflammatory myofibroblastic tumors. The goal is to find the best dose and see how safe and effective the drug is.…

This study is creating a large database of information and tissue samples from 1,000 people with T-cell lymphoma. Researchers will use this data to learn more about the disease and how to improve patient outcomes. Participants provide medical information and optional blood and na…