Age-related clonal hematopoiesis
MONDO:0100544A precancerous condition characterized by the gradual, clonal expansion of hematopoietic stem and progenitor cells carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. It is associated with an increased risk of developing hematologic cancers.
Also known as: ARCH
14 clinical trials for this condition and its sub-types, 0 tagged with Age-related clonal hematopoiesis itself.
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Milder chemo may make stem cell transplants safer for Non-Cancer patients
Disease control Recruiting nowThis phase 2 trial tests a combination of three chemotherapy drugs (treosulfan, fludarabine, thiotepa) plus an immune-suppressing antibody before a donor stem cell transplant in up to 40 people under 50 with non-cancerous blood disorders. The goal is to see if this milder conditi…
Phase 2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Can a heat probe through an endoscope treat pancreatic lesions?
Disease control Recruiting nowThis study tests whether a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) can safely treat pancreatic lesions. The approach uses a special endoscope to deliver heat energy directly to the lesion. Researchers will enroll 60 people with pre-malignan…
Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
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Simple blood test could spot cancer early
Diagnosis Recruiting nowThis study is testing a new blood test called PanTum Detect to see how well it can find early signs of cancer or pre-cancer. The test looks for certain markers in immune cells. Researchers will compare the blood test results with standard PET/CT scans in 134 adults—half with susp…
Sponsor: Comenius University • Aim: Diagnosis
Last updated Jun 27, 2026 08:11 UTC
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Scientists launch massive tumor repository to unlock cancer secrets
Knowledge-focused Recruiting nowThis study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 06, 2026 00:00 UTC
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Cancer samples sought to unlock treatment secrets
Knowledge-focused Recruiting nowThis study collects blood, bone marrow, and tumor samples from 500 adults with cancer or pre-cancerous conditions. Researchers will use these samples to learn more about how cancers behave and why some respond differently to treatments. Participants provide samples over time and …
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Massive study aims to unlock secrets of early blood cancers
Knowledge-focused Recruiting nowThis study looks at genetic changes in people with early-stage blood cancers or conditions that may lead to cancer. Researchers will analyze blood, bone marrow, or cheek cell samples from up to 10,000 participants to find DNA errors linked to cancer risk and progression. The goal…
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Massive cancer gene mapping project aims to unlock new treatments
Knowledge-focused Recruiting nowThis study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…
Sponsor: Avera McKennan Hospital & University Health Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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5000 volunteers help hunt for hidden cancer clues
Knowledge-focused Recruiting nowThis study collects tissue, blood, urine, and stool samples from 5000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could improve early detecti…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Robot vs. laparoscopic: which pancreas surgery is better?
Knowledge-focused Recruiting nowThis study compares two minimally invasive surgical techniques—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with benign or pre-cancerous growths. About 256 participants will be randomly assigned to one of the two procedures. The goal is to …
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:56 UTC