Adrenocortical insufficiency

Researchers are testing a block-and-replace strategy for people with endogenous Cushing syndrome, a condition where the body makes too much cortisol. Participants receive osilodrostat, a drug that lowers cortisol production, along with a replacement glucocorticoid called methylpr…

This study looks at whether people with inflammatory or autoimmune diseases can safely stop taking steroids (like prednisone) right away instead of slowly reducing the dose over 4 weeks. The goal is to see if stopping quickly leads to more hospital visits or adrenal crises. About…

This study is testing whether the drug ravulizumab can help people with generalized myasthenia gravis (gMG) safely reduce or stop taking oral steroids. About 75 adults who are already on ravulizumab and taking at least 7.5 mg of prednisone daily will follow a gradual steroid-tape…

This study aims to find the most accurate cortisol levels to diagnose adrenal insufficiency, a condition where the body doesn't make enough cortisol. Researchers will test 90 healthy volunteers and people already diagnosed with the condition using a new, highly specific cortisol …

This observational study will measure salivary cortisol in 220 healthy adults and people with Cushing's syndrome or adrenal insufficiency. The goal is to establish normal reference ranges and find the best cut-off values for diagnosis. Researchers will compare two lab methods to …

This study looks at whether taking extra hydrocortisone during times of mild to moderate stress (physical or mental) can improve health-related quality of life, especially fatigue, in people with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA) who are on long-term, low…

This study tests whether a low dose of hydrocortisone (a cortisol-like hormone) can reduce symptoms like fatigue and dizziness in people who have recently stopped taking prednisolone for giant cell arteritis or polymyalgia rheumatica. About 100 adults aged 50 and older will recei…

This natural history study aims to gather information from up to 3,000 people with genetic conditions that cause too much androgen (male-like hormones), such as congenital adrenal hyperplasia (CAH) and familial male-limited precocious puberty (FMPP). Participants undergo various …

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study looks at how often children with leukemia or lymphoma develop a shortage of natural stress hormones after high-dose steroid treatment. Researchers will test 40 children during and after therapy to see how long the deficiency lasts and who is most at risk. The goal is t…

This study follows 521 patients who had adrenal gland surgery for primary aldosteronism, a condition causing high blood pressure. Researchers want to see how often the remaining adrenal gland fails to produce enough cortisol after surgery, especially in patients who also had extr…