Acute pancreatitis

This trial tests an experimental drug called SGC001 in people who are likely to develop severe acute pancreatitis, a painful inflammation of the pancreas that can lead to organ failure. Participants receive either SGC001 or a placebo as a single intravenous infusion alongside sta…

This trial tests whether a special cooling tube placed near the pancreas can help people with acute pancreatitis recover faster. Participants are randomly assigned to receive either standard care alone or standard care plus the cooling device for up to three days. The study measu…

This study looks at whether a preventive endoscopic procedure (sphincterotomy) can lower the risk of future bile duct problems in frail patients who cannot have their gallbladder removed after a bout of pancreatitis caused by gallstones. About 92 adults will be randomly assigned …

This study tests whether giving the blood thinner heparin early can prevent organ failure in people hospitalized with acute pancreatitis. The inflammation from pancreatitis can cause tiny blood clots that damage organs like the lungs and kidneys. Half of the 100 participants will…

This trial investigates whether flushing the bile duct opening with ice-cold water after an ERCP procedure can reduce the chance of developing pancreatitis, a frequent complication. Researchers will compare patients who receive the flush to those who do not, looking at pancreatit…

This trial tests whether a procedure called EUS-guided gallbladder drainage can prevent future gallbladder attacks in people who are too sick or frail for surgery. Participants are randomly assigned to receive either the drainage procedure or standard medical care. The study will…

This study looks at 30 people with mild gallstone-related pancreatitis who choose not to have their gallbladder removed. Half will get an ERCP with sphincterotomy (a procedure that opens the bile duct), and half will receive standard care without the procedure. The goal is to see…

This trial tests whether a single intravenous dose of tacrolimus, given just before an ERCP procedure, can lower the chance of developing post-ERCP pancreatitis (PEP) in adults at moderate-to-high risk. Participants receive either tacrolimus or a placebo infusion, along with stan…

This trial tests whether a single dose of rectal indomethacin, a common anti-inflammatory drug, can prevent pancreatitis in patients undergoing a bile duct procedure (ERCP) who have had a prior sphincterotomy. About 860 adults will be randomly assigned to receive the drug or no d…

This study compares two doses of a rectal anti-inflammatory drug (indomethacin) to prevent pancreatitis after an ERCP procedure in people at high risk. About 1,036 adults will be randomly assigned to receive either 100 mg or 200 mg right after the procedure. The goal is to see if…

Researchers are testing whether intermittent fasting improves quality of life for adults with acute or chronic pancreatitis. Participants follow a daily 16-hour fast or receive standard calorie guidance. The study measures pancreas-related quality of life, pain, opioid use, weigh…

This study tests whether a thoracic epidural block—a numbing injection near the spine—can help people with severe acute pancreatitis avoid or shorten the need for intensive care support like breathing machines and kidney dialysis. Participants are randomly assigned to receive eit…

This study compares home management versus standard hospital care for people with mild acute pancreatitis. Participants will be randomly assigned to either go home with daily phone check-ins and a clinic visit, or stay in the hospital. The goal is to see if home care is as safe a…

This study compares an oral carbohydrate solution (a sugar drink) to a standard clear liquid diet as the first food given to people with mild to moderate acute pancreatitis. The goal is to see which approach causes fewer problems like pain or nausea and leads to a shorter hospita…

This study looks at whether routine blood test results can help predict which patients with acute pancreatitis will develop severe disease or die within 28 days. Researchers will track 109 adults admitted with acute pancreatitis and compare their blood cell ratios, such as neutro…

This study looks at adults with acute pancreatitis, a sudden inflammation of the pancreas, to understand the different ways it presents and what happens to patients. Researchers will track 100 participants to identify patterns and potential predictors of outcomes. The goal is to …

This study looks at whether early endoscopic findings in the stomach and duodenum can help predict how severe acute pancreatitis will become. Researchers will perform an upper GI endoscopy within 24-48 hours of hospital admission in 200 adult patients with acute pancreatitis. The…

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This study looks at two scoring systems, NEWS-2 and NEWS-Calcium, to see which better predicts the risk of dying in the hospital for people aged 65 and older with acute pancreatitis. Researchers will review medical records of 350 patients to compare the scores. The goal is to hel…

This study will compare two different schedules for removing pancreatic stents placed during ERCP to prevent pancreatitis. One group will have the stent removed after 1-3 months, while the other will have it removed within 10 days. The goal is to see which timing leads to fewer c…

This study looks at whether the ratio of C-reactive protein to albumin (CAR) in the blood can help predict acute kidney injury in people with acute pancreatitis. Researchers will measure CAR in 150 adults admitted to Assiut University Hospitals and see how it relates to kidney pr…

This study will look at whether certain markers from a standard complete blood count (CBC) can help doctors assess how severe acute pancreatitis is and predict patient outcomes. Researchers will analyze data from 100 adult patients treated for acute pancreatitis. The goal is to s…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…