Acute opioid poisoning

MONDO:0018173

Acute opioid poisoning is a rare intoxication with opioids, a large group of alkaloid analgesics, mainly characterized by miosis (pinpoint pupil), respiratory depression (bradypnea/apnea) and central nervous system depression (sedation or coma). Other manifestations include hypotension, reduced bowel motility, hypothermia and hypoglycemia. Naloxone, a competitive inhibitor of the mu-opioid receptor, is a potent antagonist and is used as the antidote for opioid intoxication.

38 clinical trials for this condition and its sub-types, 36 tagged with Acute opioid poisoning itself.

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↑ Acute disease (4756) ↑ Poisoning (313)

Including sub-types (38) Tagged with Acute opioid poisoning (36)

Trials to join now! 12 Not yet recruiting 8 Not yet finished but already full! 10 Completed 7 Terminated 1

Can a better antidote stop opioid overdoses faster?

Disease control Stopped early

This study investigates how effectively two opioid antidotes—naloxone (given as a nasal spray or injection) and nalmefene (given as an injection)—can reverse dangerous breathing problems caused by strong opioids like fentanyl. The trial includes both healthy volunteers and people…

Phase 1 • Sponsor: Leiden University Medical Center • Aim: Disease control

Last updated Jul 31, 2026 00:00 UTC

Acute opioid poisoning

Where it sits in the disease tree

Can a better antidote stop opioid overdoses faster?