Acute opioid poisoning
MONDO:0018173Acute opioid poisoning is a rare intoxication with opioids, a large group of alkaloid analgesics, mainly characterized by miosis (pinpoint pupil), respiratory depression (bradypnea/apnea) and central nervous system depression (sedation or coma). Other manifestations include hypotension, reduced bowel motility, hypothermia and hypoglycemia. Naloxone, a competitive inhibitor of the mu-opioid receptor, is a potent antagonist and is used as the antidote for opioid intoxication.
38 clinical trials for this condition and its sub-types, 36 tagged with Acute opioid poisoning itself.
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Smart mask alarms may spot breathing trouble before it turns critical
Disease control Not yet recruitingThis trial tests a new monitoring device, the Linshom CPRM, which fits into an oxygen mask or nasal cannula and alerts nurses when a patient's breathing starts to fail. Researchers will compare standard monitoring plus the Linshom alarm against standard monitoring alone in about …
Sponsor: Linshom Medical, Inc. • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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A second chance after overdose: does structured Follow-Up keep patients in care?
Disease control Not yet recruitingThis study tests whether a structured early addiction care program, including a consultation, toxicology feedback, and regular follow-up calls over six months, helps people who come to the emergency room after a drug overdose stay engaged in addiction treatment. Adults hospitaliz…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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Overdose prevention program aims to save homeless Veterans' lives
Disease control Not yet recruitingThis study tests a program that provides overdose education and naloxone (a drug that reverses opioid overdoses) to homeless veterans at risk. The program is being rolled out at VA sites that serve veterans in supportive housing. Researchers will measure how well sites adopt the …
Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
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New ER discharge plan aims to stop opioid overdose deaths
Disease control Not yet recruitingThis study tests a combination of telehealth, peer support, and medication (buprenorphine) to help people with opioid use disorder stay in treatment after leaving the emergency room. The goal is to reduce repeat overdoses and prevent deaths. About 160 adults who have had an opioi…
Phase 4 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Mailed test strips aim to slash opioid overdose deaths
Prevention Not yet recruitingThis study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…
Sponsor: University of Alabama at Birmingham • Aim: Prevention
Last updated Sep 17, 2026 00:00 UTC
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New app aims to cut HIV and overdose risk for women leaving jail
Prevention Not yet recruitingThis study tests a mobile app called PA-LINKS designed to help women who have recently been in jail or prison access HIV prevention medicine (PrEP) and treatment for opioid use disorder. About 74 women will use the app and work with a navigator to connect to these services. The g…
Sponsor: Temple University • Aim: Prevention
Last updated Jun 27, 2026 12:33 UTC
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New tool aims to prevent opioid overdose during dose tapering
Prevention Not yet recruitingThis study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…
Sponsor: University of Colorado, Denver • Aim: Prevention
Last updated Jun 27, 2026 12:23 UTC
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Can a fast naloxone dose save hearts stopped by opioids?
Symptom relief Not yet recruitingResearchers are testing whether giving naloxone soon after resuscitation starts can help people whose hearts stop outside the hospital after an opioid overdose. The trial enrolls adults in out-of-hospital cardiac arrest who are at risk of opioid involvement and who have received …
Phase 2 • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Sep 13, 2026 00:00 UTC