Acute liver failure
MONDO:0019542Rapid deterioration of liver function causing encephalopathy and coagulopathy. It results from damage to the liver parenchyma usually secondary to acetaminophen overdose or viral infections.
Also known as: acute hepatic failure, fulminant hepatic failure
25 clinical trials for this condition and its sub-types, 16 tagged with Acute liver failure itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Acute liver failure
-
Can calming the immune system save Kids' livers?
Disease control OngoingThis study tests whether two drugs that calm the immune system—high-dose steroids or anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned to receive one of…
Phase 2 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
-
Stem cell injection aims to prevent deadly liver complication
Disease control By invitation onlyThis early-phase trial tests whether injecting special liver-like cells into the abdominal muscle can help prevent or treat Small-for-Size syndrome, a serious complication that can occur after partial liver surgery. The study involves 12 patients and focuses mainly on safety, che…
Early phase 1 • Sponsor: Zhi-Jun Zhu • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
-
Scientists hunt for clues in body fluids to predict liver failure outcomes
Knowledge-focused OngoingThis study aims to find biological markers in blood, urine, stool, and breath that can predict how patients with acute liver injury or failure will fare. Researchers will collect samples daily for up to seven days from 200 participants, and a small group will also undergo MRI sca…
Sponsor: University of Edinburgh • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC
-
Scientists track rare liver diseases in kids to unlock clues
Knowledge-focused PausedThis study follows up to 90 children and young adults with mitochondrial liver diseases to learn how these conditions progress over time. Researchers will collect medical data and samples to better understand the diseases and find markers that predict outcomes. The goal is to imp…
Sponsor: Arbor Research Collaborative for Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC