Actinic keratosis

This study tests a gel (Ameluz®) plus red light therapy for actinic keratosis, rough precancerous patches on skin. It includes 172 adults with 4-15 spots on arms, legs, neck, or trunk. The goal is to see if the treatment clears these spots better than a placebo gel.

This trial tests whether a lower-strength light-activated gel (8% vs. 16%) and a shorter wait time before red light treatment (1 hour vs. 3 hours) can effectively clear actinic keratoses—rough, precancerous spots caused by sun damage—on the face. Participants will receive one of …

This study compares two different incubation times for a light-activated cream used to treat actinic keratosis, a common precancerous skin condition caused by sun exposure. Participants receive either no wait or a one-hour wait after applying the cream before blue light therapy. …

This study tested an ointment called tirbanibulin (Klisyri®) on adults with actinic keratosis, a common precancerous skin condition caused by sun exposure. The trial included 280 participants and applied the ointment to larger skin areas (up to 100 cm²) on the face or balding sca…

This small study tested whether a gel called Ameluz, activated by a special broadband light (BBL), can treat both actinic keratoses (rough, scaly spots that can turn into skin cancer) and general sun damage on the face. Ten adults with mild to moderate skin damage received two tr…

This study tested whether the drug everolimus can reduce new skin cancers in heart transplant patients who already had skin cancer. 175 participants received either everolimus or standard immunosuppressants. The goal was to see if everolimus lowers the number of new skin tumors n…

This study tested whether a 1-hour indoor light treatment works as well as the standard 2-hour version for actinic keratosis (scaly sun-damaged spots) on the scalp. Fifty-five adults with multiple lesions received both durations on different sides of their scalp. Researchers meas…

This study tested a non-invasive device that uses light to classify skin lesions as healthy, actinic keratosis, or carcinoma. Researchers aimed to see if it could help doctors diagnose skin conditions more accurately without needing a biopsy. The study involved 142 adults with su…

This study tested whether an artificial intelligence (AI) tool could help primary care doctors diagnose skin conditions more accurately. Nine doctors reviewed 30 images of various skin problems, first giving their own diagnosis and then a final diagnosis after seeing the AI's sug…

This study tested whether taking nicotinamide (a form of vitamin B3) as a pill or applying it as a cream could reduce precancerous skin spots called actinic keratoses on the face. 74 adults with at least three such spots were randomly assigned to receive either oral nicotinamide …

This study tested a new device called Flexitheralight against the usual light therapy for actinic keratosis, which are rough spots caused by sun damage. About 29 adults with at least 10 spots on their forehead or scalp took part. The goal was to see if the new device works just a…

This study tested whether shorter incubation times for a topical gel (10% ALA) before red-light photodynamic therapy (PDT) could reduce pain while still effectively clearing actinic keratoses (AKs) on the face. Thirty adults with at least 10 AK lesions were randomly assigned to h…

This study examined 119 people with precancerous or early skin cancer lesions to understand how cells change as they become cancerous. Researchers took small skin samples and analyzed their metabolism and protein markers. The goal was to learn more about the transition from harml…

This study tested a new video device that takes images of skin lesions during photodynamic therapy (PDT) for actinic keratoses, a common precancerous skin condition. The goal was to see if the device could predict how well the treatment works by measuring certain chemicals in the…

This early-stage study tested a new cream called GZ21T in 41 healthy adults to see if it is safe and how the body absorbs it. The cream is being developed for actinic keratosis, a skin condition that can lead to cancer. No treatment was given; the goal was only to check for side …

This study tested a new handheld device that measures a natural chemical called protoporphyrin IX in the skin. This chemical is important for photodynamic therapy, a light-based treatment for certain skin conditions. Researchers measured the chemical levels in 219 adults at diffe…