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Can a new Weight-Loss shot replace wegovy without stomach trouble?

NCT ID NCT07812597

Disease control Sponsor: Beijing QL Biopharmaceutical Co.,Ltd Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers are testing whether adults with obesity can safely switch from semaglutide (Wegovy) to an experimental drug called zovaglutide. The trial enrolls 210 people aged 18 to 75 with a BMI of at least 28 who do not have diabetes. Participants first receive semaglutide injections, then some switch to zovaglutide while others continue semaglutide, and researchers track side effects and whether the switch succeeds.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
zovaglutide, an experimental weight-loss injection
What this could lead to
If it works, people with obesity could have another injectable option for weight management, possibly with fewer stomach side effects than current drugs.
What could go wrong
This is a phase 2 trial with 210 participants, so safety and tolerability data are early. Switching drugs may cause gastrointestinal side effects or fail to control weight, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 210 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female subjects aged≥18years and≤75 years at the time of signing the Informed Consent Form (ICF). * At screening, Body Mass Index (BMI)≥28kg/m² * Weight change due to diet and exercise alone within 3 months prior to screening did not exceed 5%. Exclusion Criteria: * Previously diagnosed obesity caused by monogenic mutations, other diseases, or medications. * Previous diagnosis of diabetes; or HbA1c ≥ 6.5% or fasting blood glucose ≥ 7.0 mmol/L at screening. * Used of medicines or treatments that affect weight within 3 months prior to screening. * History of acute or chronic pancreatitis, or pancreatic injury. * History of medullary thyroid carcinoma (MTC) or type 2 multiple endocrine neoplasia (MEN2) in personal or family history. * History of medullary thyroid carcinoma (MTC) or type 2 multiple endocrine neoplasia (MEN2) in personal or family history. * Patient Health Questionnaire-9 (PHQ-9) scale score is ≥ 15 at screening * Screening Columbia-Suicide Severity Rating Scale(C-SSRS) questionnaire suicide ideation response of "Category 4 or 5," or any "yes" response to suicidal behavior questions

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    16 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050, China

  • Central Hospital Affiliated to Shandong First Medical University

    Jinan, Shandong, 250000, China

  • Handan First Hospital

    Handan, Hebei, 056002, China

  • Harbin Medical University Affiliated Fourth Hospital

    Harbin, Heilongjiang, 150001, China

  • Hebei Petro China Cental Hospital

    Langfang, Hebei, 065000, China

  • Huizhou Central People's Hospital

    Huizhou, Guangdong, 516008, China

  • Jilin Province FAW General Hospital

    Changchun, Jilin, 130011, China

  • Jincheng General Hospital

    Jincheng, Shanxi, 48006, China

  • Peking University People's Hospital

    Beijing, Beijing Municipality, 100044, China

  • The 2nd People's Hospital of Chengdu

    Chengdu, Sichuan, 610021, China

  • The Fifth People's Hospital of Shenyang

    Shenyang, Liaoning, 110023, China

  • The First Affiliated of Nanyang Medical College

    Nanyang, Henan, 473000, China

  • The First People's Hospital of Changde

    Changde, Hunan, 415003, China

  • Yichang Central People's Hospital (Xiling Campus)

    Yichang, Hubei, 443000, China

  • Zibo Central Hospital

    Zibo, Shandong, 255036, China

  • Zibo Municipal Hospital

    Zibo, Shandong, 255400, China

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