New pill targets HER2 cancers in phase 2 trial

NCT ID NCT06581432

Recruiting now Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 6 times

Summary

This study tests an oral drug called zongertinib in adults with advanced solid tumors that have HER2 mutations or overexpression and have not responded to prior treatment. Participants take one of two daily doses and continue as long as they benefit. Doctors regularly check tumor size and overall health to see if the drug shrinks tumors and how safe it is.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zongertinib (a daily oral drug that blocks HER2, a protein that can fuel cancer growth)
What this could lead to: If successful, zongertinib could offer a new treatment option for people with advanced cancers that have HER2 changes and have stopped responding to other therapies.
What could go wrong: This is an early-phase (Phase 2) trial with no control group, so results are preliminary. The drug may not shrink tumors in many participants, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOURS

Contacts and locations

Locations

AOU Università degli Studi della Campania Luigi Vanvitelli
RECRUITING

Naples, 80131, Italy
ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
Aichi Cancer Center Hospital
RECRUITING

Aichi, Nagoya, 464-8681, Japan
Alaska Oncology and Hematology, LLC
RECRUITING

Anchorage, Alaska, 99508, United States
Alliance Cancer Specialists, PC, Wynnewood
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Anhui Provincial Cancer Hospital
NOT_YET_RECRUITING

Hefei, 230001, China
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Asklepios Kliniken GmbH & Co. KGaA
RECRUITING

Hamburg, 22763, Germany
Az. Ospedaliere Umberto I di Ancona
RECRUITING

Ancona, 60020, Italy
BC Cancer Agency - Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
BRCR Global
RECRUITING

Tamarac, Florida, 33321, United States
CTR Georges-François Leclerc
RECRUITING

Dijon, 21079, France
CTR Leon Berard
RECRUITING

Lyon, 69373, France
Cancer Research South Australia
NOT_YET_RECRUITING

Adelaide, South Australia, 5000, Australia
Centre Hospitalier de l'Universite de Montreal (CHUM)
RECRUITING

Montreal, Quebec, H2X 0A9, Canada
Centro di riferimento Oncologico
NOT_YET_RECRUITING

Aviano (PN), 33081, Italy
Charité - Universitätsmedizin Berlin
NOT_YET_RECRUITING

Berlin, 12203, Germany
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Clínica Universidad de Navarra
RECRUITING

Pamplona, 31008, Spain
Clínica Universidad de Navarra - Madrid
RECRUITING

Madrid, 28027, Spain
Community MD Anderson Cancer Center - East Medical Oncology
RECRUITING

Indianapolis, Indiana, 46219, United States
Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, 15006, Spain
Cross Cancer Institute (University of Alberta)
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Fondazione Policlinico Universitario Campus Bio-medico
NOT_YET_RECRUITING

Rome, 00128, Italy
GenesisCare North Shore
RECRUITING

St Leonards, New South Wales, 2065, Australia
HOP Timone
RECRUITING

Marseille, 13385, France
HOP la Milétrie
RECRUITING

Poitiers, 86000, France
Hammersmith Hospital
NOT_YET_RECRUITING

London, W12 0HS, United Kingdom
Henan Cancer Hospital
RECRUITING

Zhengzhou, 450008, China
Hokkaido University Hospital
RECRUITING

Hokkaido, Sapporo, 060-8648, Japan
Hospital Clinico De Valencia (INCLIVA)
NOT_YET_RECRUITING

Valencia, 46010, Spain
Hospital Clínico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Duran i Reynals
NOT_YET_RECRUITING

Barcelona, 08908, Spain
Hospital Germans Trias i Pujol
NOT_YET_RECRUITING

Badalona, 08916, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
INS Bergonie
RECRUITING

Bordeaux, 33000, France
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Illinois Cancer Specialists
RECRUITING

Arlington Heights, Illinois, 60005, United States
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France
Istituto Scientifico Romagnolo
RECRUITING

Meldola (FC), 47014, Italy
Japanese Foundation for Cancer Research
RECRUITING

Tokyo, Koto-ku, 135-8550, Japan
Justus-Liebig Universität Gießen
RECRUITING

Giessen, 35392, Germany
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Klinikum rechts der Isar der Technischen Universität München
RECRUITING

München, 81675, Germany
Kyushu University Hospital
RECRUITING

Fukuoka, Fukuoka, 812-8582, Japan
Macquarie University
RECRUITING

Macquarie Park, New South Wales, 2109, Australia
Maryland Oncology Hematology, Columbia
RECRUITING

Columbia, Maryland, 21044, United States
McGill University Health Centre (MUHC)
COMPLETED

Montreal, Quebec, H4A 3J1, Canada
Memorial Sloan-Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
National Cancer Center Hospital
RECRUITING

Tokyo, Chuo-ku, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Chiba, Kashiwa, 277-8577, Japan
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore
Nederlands Kanker Instituut
RECRUITING

Amsterdam, 1066 CX, Netherlands
Ninewells Hospital & Medical School
RECRUITING

Dundee, DD1 9SY, United Kingdom
Okayama University Hospital
NOT_YET_RECRUITING

Okayama, Okayama, 700-8558, Japan
Osaka International Cancer Institute
RECRUITING

Osaka, Osaka, 541-8567, Japan
Oslo Universitetssykehus HF, Radiumhospitalet
RECRUITING

Oslo, N-0379, Norway
Pan American Center for Oncology Trials, LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Peking University First Hospital
RECRUITING

Beijing, 100034, China
Precision NextGen Oncology
RECRUITING

Beverly Hills, California, 90212, United States
Presbyterian Healthcare Services
RECRUITING

Albuquerque, New Mexico, 87110, United States
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Radboud Universitair Medisch Centrum
RECRUITING

Nijmegen, 6525 GL, Netherlands
Samsung Medical Center
RECRUITING

Seoul, 135-710, South Korea
Sarah Cannon Research Institute at Mary Crowley
RECRUITING

Dallas, Texas, 75230, United States
Scripps Cancer Center Torrey Pines
RECRUITING

La Jolla, California, 92037, United States
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital
RECRUITING

Seoul, 03722, South Korea
Shanghai East Hospital
RECRUITING

Shanghai, 200120, China
Shanghai GoBroad Cancer Hospital
RECRUITING

Shanghai, 200131, China
Shizuoka Cancer Center
RECRUITING

Shizuoka, Sunto-gun, 411-8777, Japan
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
RECRUITING

Hangzhou, 310016, China
St John of God Subiaco Hospital
RECRUITING

Subiaco, Western Australia, 6008, Australia
Taylor Cancer Research Center
RECRUITING

Maumee, Ohio, 43537, United States
Texas Oncology - Plano West
RECRUITING

Plano, Texas, 75093, United States
The Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, 330006, China
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Union Hospital Tongji Medical College Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, 430022, China
Universitair Ziekenhuis Antwerpen
RECRUITING

Edegem, 2650, Belgium
University of Arizona Comprehensive Cancer Center
RECRUITING

Tucson, Arizona, 85719, United States
Universität Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitätsklinikum Mannheim GmbH
RECRUITING

Mannheim, 68167, Germany
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Virginia Cancer Specialists, PC
RECRUITING

Fairfax, Virginia, 22031, United States
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06511, United States

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