New hope for blood cancer: targeted therapy combo shows promise in phase 2 trial

NCT ID NCT06890884

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 9 times

Summary

This study tests whether a new drug, zilovertamab vedotin, combined with standard chemotherapy (R-CHP) works better than another approved drug combo for people with a specific type of fast-growing blood cancer called GCB diffuse large B-cell lymphoma. About 594 adults who have not had treatment before will take part. The main goal is to see if the cancer completely disappears after treatment.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma diffuse large B-cell lymphoma germinal center B-cell type

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA, LARGE B-CELL, DIFFUSE

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

AZ Delta ( Site 0303)
RECRUITING

Roeselare, West-Vlaanderen, 8800, Belgium
AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0306)
RECRUITING

Mechelen, Antwerpen, 2800, Belgium
Abramson Cancer Center and Perelman Center for Advanced Medicine ( Site 0131)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Aichi Cancer Center ( Site 1007)
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Alliance Cancer Specialists (ACS) ( Site 8010)
RECRUITING

Sellersville, Pennsylvania, 18960, United States
Arcispedale Santa Maria Nuova ( Site 0706)
RECRUITING

Reggio Emilia, 42123, Italy
Atlantic Health Morristown Medical Center ( Site 0163)
RECRUITING

Morristown, New Jersey, 07960, United States
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 0702)
RECRUITING

Palermo, Sicily, 90146, Italy
Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0703)
RECRUITING

Alessandria, 15121, Italy
Baptist Health Hardin ( Site 0154)
RECRUITING

Elizabethtown, Kentucky, 42701, United States
Baptist Health Lexington ( Site 0127)
RECRUITING

Lexington, Kentucky, 40503, United States
Baptist MD Anderson Cancer Center ( Site 0176)
RECRUITING

Jacksonville, Florida, 32207, United States
Bass Medical Group ( Site 0123)
RECRUITING

Walnut Creek, California, 94598, United States
Beacon Cancer Care ( Site 0142)
RECRUITING

Post Falls, Idaho, 83854, United States
Beth Israel Deaconess Medical Center ( Site 0161)
RECRUITING

Boston, Massachusetts, 02215, United States
Boca Raton Regional Hospital-Lynn Cancer Institute ( Site 0130)
RECRUITING

Boca Raton, Florida, 33486, United States
Bozeman Health Deaconess Hospital ( Site 0183)
RECRUITING

Bozeman, Montana, 59715, United States
Bristol Haematology and Oncology Centre ( Site 0908)
RECRUITING

Bristol, Bristol, City of, BS2 8ED, United Kingdom
Cancer Care Associates Of York ( Site 0174)
RECRUITING

York, Pennsylvania, 17403, United States
Centrum für Hämatologie und Onkologie Bethanien ( Site 0417)
RECRUITING

Frankfurt am Main, Hesse, 60389, Germany
Christie Hospital NHS Trust ( Site 0901)
RECRUITING

Manchester, M20 4BX, United Kingdom
Churchill Hospital ( Site 0903)
RECRUITING

Oxford, Oxfordshire, OX3 7LJ, United Kingdom
City of Hope - Phoenix ( Site 0202)
RECRUITING

Goodyear, Arizona, 85338, United States
City of Hope Comprehensive Cancer Center ( Site 0191)
RECRUITING

Duarte, California, 91010, United States
Clatterbridge Cancer Centre - Liverpool ( Site 0911)
RECRUITING

Liverpool, L7 8YA, United Kingdom
Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 0199)
RECRUITING

Mayfield Heights, Ohio, 44124, United States
Cleveland Clinic Main ( Site 0101)
RECRUITING

Cleveland, Ohio, 44195, United States
Cliniques Universitaires Saint-Luc ( Site 0302)
RECRUITING

Brussels, Bruxelles-Capitale, Region de, 1200, Belgium
Colorado West Healthcare System-Grand Valley Oncology ( Site 0165)
RECRUITING

Grand Junction, Colorado, 81505, United States
Dana Farber Cancer Institute ( Site 0111)
RECRUITING

Boston, Massachusetts, 02215, United States
Dietrich Bonhoeffer Klinikum-Neubrandenburg ( Site 0439)
RECRUITING

Neubrandenburg, Mecklenburg-Vorpommern, 17036, Germany
Edith Wolfson Medical Center ( Site 0602)
RECRUITING

Holon, 5810001, Israel
Erie County Medical Center ( Site 0175)
COMPLETED

Buffalo, New York, 14215, United States
Fairview Hospital-Moll Cancer Center ( Site 0198)
RECRUITING

Cleveland, Ohio, 44111, United States
Fujita Health University Hospital ( Site 1003)
RECRUITING

Toyoake, Aichi-ken, 470-1192, Japan
Genesis Cancer and Blood Institute ( Site 0193)
RECRUITING

Hot Springs, Arkansas, 71913, United States
Georgetown University Medical Center ( Site 0117)
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Guy s & St Thomas NHS Foundation Trust ( Site 0904)
RECRUITING

London, London, City of, SE1 9RT, United Kingdom
HELIOS Klinikum Wuppertal ( Site 0435)
RECRUITING

Wuppertal, North Rhine-Westphalia, 42283, Germany
Haddasah Medical Center ( Site 0601)
RECRUITING

Jerusalem, 9112001, Israel
Hammersmith Hospital ( Site 0915)
RECRUITING

London, London, City of, W12 0 HS, United Kingdom
Hokkaido University Hospital ( Site 1004)
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hopital de Jolimont ( Site 0304)
RECRUITING

Haine-Saint-Paul, Hainaut, 7100, Belgium
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 0707)
RECRUITING

Meldola, Forli-Cesena, 47014, Italy
Illinois Cancer Care ( Site 7005)
RECRUITING

Peoria, Illinois, 61615, United States
Infirmary Cancer Care ( Site 0157)
RECRUITING

Mobile, Alabama, 36607, United States
Intermountain Healthcare - St. George ( Site 0203)
RECRUITING

St. George, Utah, 84790, United States
Intermountain Medical Center ( Site 0182)
RECRUITING

Murray, Utah, 84107, United States
Ironwood Cancer & Research Centers ( Site 0204)
RECRUITING

Chandler, Arizona, 85224, United States
Istituto Clinico Humanitas ( Site 0704)
RECRUITING

Rozzano, Milano, 20089, Italy
Istituto Europeo di Oncologia ( Site 0701)
RECRUITING

Milan, 20141, Italy
Johanniter Krankenhaus Bonn ( Site 0440)
RECRUITING

Bonn, North Rhine-Westphalia, 53113, Germany
KRH Klinikum Siloah ( Site 0441)
RECRUITING

Hanover, Lower Saxony, 30459, Germany
Kansai Medical University Hospital ( Site 1006)
RECRUITING

Hirakata, Osaka, 573-1191, Japan
Klinikum Chemnitz gGmbH ( Site 0405)
RECRUITING

Chemnitz, Saxony, 09113, Germany
Klinikum Kassel GmbH ( Site 0434)
RECRUITING

Kassel, Hesse, 34125, Germany
Klinikum Stuttgart. Klinik fur Hamatologie. Onkologie. Palliativmedizin und Stammzelltransplantation ( Site 0419)
RECRUITING

Stuttgart, Baden-Wurttemberg, 70174, Germany
LMU Klinikum ( Site 0428)
RECRUITING

Munich, Bavaria, 81377, Germany
Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0108)
RECRUITING

New York, New York, 10016, United States
Lincoln County Hospital ( Site 0906)
RECRUITING

Lincoln, Lincolnshire, LN2 5QY, United Kingdom
Louisiana State University Health Sciences Shreveport ( Site 0195)
RECRUITING

Shreveport, Louisiana, 71103, United States
Mater Misercordiae University Hospital ( Site 0501)
RECRUITING

Dublin, D07 R2WY, Ireland
Medical College of Wisconsin ( Site 0103)
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants (MOHC) ( Site 8007)
RECRUITING

Newark, Delaware, 19713, United States
Medical University of South Carolina ( Site 0153)
RECRUITING

Charleston, South Carolina, 29425, United States
Mid Florida Hematology and Oncology Center ( Site 0152)
RECRUITING

Orange City, Florida, 32763, United States
Minnesota Oncology Hematology (MNO) ( Site 8004)
RECRUITING

Burnsville, Minnesota, 55337, United States
Mission Blood & Cancer Care ( Site 0114)
RECRUITING

Waukee, Iowa, 50263, United States
Mount Sinai Braman Comprehensive Cancer Center ( Site 0140)
RECRUITING

Miami Beach, Florida, 33140, United States
NHO Revive Research Institute, LLC ( Site 0121)
RECRUITING

Lincoln, Nebraska, 68506, United States
Nagasaki University Hospital ( Site 1008)
RECRUITING

Nagasaki, 852-8501, Japan
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0803)
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
National Cancer Center Hospital ( Site 1009)
RECRUITING

Chūō, Tokyo, 104-0045, Japan
National Hospital Organization Sendai Medical Center ( Site 1005)
RECRUITING

Sendai, Miyagi, 983-8520, Japan
Nippon Medical School Hospital ( Site 1001)
RECRUITING

Bunkyo, Tokyo, 113-8603, Japan
Northwest Cancer Specialists (Compass Oncology) ( Site 8000)
RECRUITING

Vancouver, Washington, 98684, United States
Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185)
RECRUITING

Louisville, Kentucky, 40207, United States
Novant Health Forsyth Medical Center ( Site 0206)
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Novant Health Presbyterian Medical Center ( Site 0177)
RECRUITING

Charlotte, North Carolina, 28204, United States
Ochsner Clinic Foundation ( Site 0189)
RECRUITING

New Orleans, Louisiana, 70121, United States
Ochsner LSU Health - Monroe Medical Center, Family Medicine Clinic ( Site 0209)
RECRUITING

Monroe, Louisiana, 71202, United States
Optum Medical Care, PC ( Site 0122)
RECRUITING

Westbury, New York, 11590, United States
Otto-Von-Guericke-Universitaet Magdeburg ( Site 0411)
RECRUITING

Magdeburg, Saxony-Anhalt, 39120, Germany
Our Lady of the Lake Physician Group-Medical Oncology ( Site 0180)
RECRUITING

Baton Rouge, Louisiana, 70808, United States
Palo Verde Cancer Specialists ( Site 0105)
RECRUITING

Glendale, Arizona, 85304, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0208)
RECRUITING

Mineola, New York, 11501, United States
Pratia MCM Krakow ( Site 0804)
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-727, Poland
Pratia Onkologia Katowice ( Site 0801)
RECRUITING

Katowice, Silesian Voivodeship, 40-519, Poland
Providence Oncology and Hematology Clinic Westside ( Site 0179)
RECRUITING

Portland, Oregon, 97225, United States
Providence Portland Medical Center ( Site 0120)
RECRUITING

Portland, Oregon, 97213, United States
Queen Elizabeth Hospital Birmingham ( Site 0912)
RECRUITING

Birmingham, B15 2TH, United Kingdom
Rabin Medical Center ( Site 0607)
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Health Care Campus ( Site 0604)
RECRUITING

Haifa, 3109601, Israel
Rocky Mountain Cancer Centers (RMCC) ( Site 8001)
RECRUITING

Aurora, Colorado, 80012, United States
Roswell Park Cancer Institute ( Site 0192)
RECRUITING

Buffalo, New York, 14263, United States
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0135)
RECRUITING

Burbank, California, 91505, United States
Royal Devon & Exeter Hospital ( Site 0910)
RECRUITING

Exeter, Devon, EX2 5DW, United Kingdom
SCRI Oncology Partners ( Site 7002)
RECRUITING

Nashville, Tennessee, 37203, United States
SSM Health Dean Medical Group ( Site 0106)
RECRUITING

Madison, Wisconsin, 53715, United States
SUNY Upstate Cancer Center ( Site 0178)
RECRUITING

Syracuse, New York, 13210, United States
Saint Elizabeth Medical Center Edgewood ( Site 0141)
RECRUITING

Edgewood, Kentucky, 41017, United States
Sheba Medical Center ( Site 0603)
RECRUITING

Ramat Gan, 5265601, Israel
Shimane University Hospital ( Site 1002)
RECRUITING

Izumo, Shimane, 693-8501, Japan
Soroka Medical Center ( Site 0606)
RECRUITING

Beersheba, 8410101, Israel
Sourasky Medical Center ( Site 0608)
RECRUITING

Tel Aviv, 6423906, Israel
Specjalistyczny Szpital im. Dr Alfreda Sokolowskiego w Walbrzychu ( Site 0807)
RECRUITING

Wałbrzych, Lower Silesian Voivodeship, 58-309, Poland
St Vincent's University Hospital ( Site 0502)
RECRUITING

Dublin, Dublin, D04 T6F4, Ireland
Stoke Mandeville Hospital ( Site 0917)
RECRUITING

Aylesbury, Buckinghamshire, HP21 8AL, United Kingdom
Szpital Specjalistyczny im. Jedrzeja Sniadeckiego w Nowym Saczu ( Site 0806)
RECRUITING

Nowy Sącz, Lesser Poland Voivodeship, 33-300, Poland
Temple University Hospital ( Site 0133)
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
Tennessee Cancer Specialists ( Site 7004)
RECRUITING

Knoxville, Tennessee, 37909, United States
Texas Oncology - Central/South Texas ( Site 8006)
RECRUITING

Austin, Texas, 78705, United States
Texas Oncology - Northeast Texas ( Site 8002)
RECRUITING

Palestine, Texas, 75801, United States
Texas Oncology - San Antonio ( Site 8009)
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology - West Texas ( Site 8008)
RECRUITING

Amarillo, Texas, 79124, United States
The James Cook University Hospital ( Site 0909)
RECRUITING

Middlesbrough, England, TS4 3BW, United Kingdom
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0145)
COMPLETED

Tyler, Texas, 75701, United States
UT Southwestern Medical Center ( Site 0190)
RECRUITING

Dallas, Texas, 75390, United States
UZ Leuven ( Site 0301)
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
Uniklinik Erlangen ( Site 0412)
RECRUITING

Erlangen, Bavaria, 91054, Germany
Universita degli Studi di Napoli Federico II ( Site 0705)
RECRUITING

Naples, 80131, Italy
UniversitaetsklInikum Tuebingen ( Site 0410)
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck ( Site 0425)
RECRUITING

Lübeck, Schleswig-Holstein, 23562, Germany
Universitaetsklinikum Wuerzburg ( Site 0401)
RECRUITING

Würzburg, Bavaria, 97080, Germany
University Hospital Limerick ( Site 0503)
RECRUITING

Limerick, V94 F858, Ireland
University Hospitals Plymouth NHS Trust ( Site 0905)
RECRUITING

Plymouth, Devon, PL68DH, United Kingdom
University Hospitals of Cleveland ( Site 0155)
RECRUITING

Cleveland, Ohio, 44106, United States
University Of Nebraska Medical Center ( Site 0110)
RECRUITING

Omaha, Nebraska, 68198, United States
University of Chicago Medical Center ( Site 0126)
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center ( Site 0156)
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Iowa-Holden Comprehensive Cancer Center ( Site 0139)
RECRUITING

Iowa City, Iowa, 52242, United States
University of North Carolina Medical Center ( Site 0136)
RECRUITING

Chapel Hill, North Carolina, 27514, United States
Universitätsklinikum Aachen ( Site 0418)
RECRUITING

Aachen, North Rhine-Westphalia, 52074, Germany
Universitätsklinikum Jena ( Site 0438)
RECRUITING

Jena, Thuringia, 07747, Germany
Uniwersyteckie Centrum Kliniczne ( Site 0802)
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-214, Poland
VCU Health Adult Outpatient Pavillion ( Site 0138)
RECRUITING

Richmond, Virginia, 23219, United States
VITAZ ( Site 0307)
RECRUITING

Sint-Niklaas, Oost-Vlaanderen, 9100, Belgium
Valley Health Systems - Ridgewood Campus ( Site 0125)
RECRUITING

Paramus, New Jersey, 07652, United States
Virginia Cancer Specialists, PC ( Site 8003)
RECRUITING

Manassas, Virginia, 20110, United States
ZIV Medical Center ( Site 0605)
RECRUITING

Safed, 13100, Israel

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