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New immunotherapy MK-1045 takes on tough lymphomas

NCT ID NCT07519772

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 10 times

Summary

This study tests an experimental immunotherapy called MK-1045 in 200 people with two types of non-Hodgkin lymphoma: follicular lymphoma (slow-growing) and diffuse large B-cell lymphoma (fast-growing). Participants have already tried at least two other treatments without success. The trial aims to see if MK-1045 is safe and whether it can shrink or eliminate tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
MK-1045 (also called CN-201), an immunotherapy drug given by IV or injection
What this could lead to
If successful, MK-1045 could offer a new treatment option for people with certain types of non-Hodgkin lymphoma that have not responded to prior therapies.
What could go wrong
This is an early-phase trial (1b/2) with only 200 participants, so results may not apply to everyone. The main focus is safety, and it is not yet known if MK-1045 will shrink tumors or improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma follicular lymphoma lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA, FOLLICULAR LYMPHOMA, LARGE B-CELL, DIFFUSE LYMPHOMA, NON-HODGKIN

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Antalya Egitim ve Arastirma Hastanesi ( Site 1003)

    RECRUITING

    Antalya, 7100, Turkey (Türkiye)

  • Beijing Cancer hospital ( Site 1701)

    RECRUITING

    Beijing, Beijing Municipality, 100142, China

  • Box Hill Hospital ( Site 0202)

    RECRUITING

    Box Hill, Victoria, 3128, Australia

  • Carmel Hospital ( Site 0602)

    RECRUITING

    Haifa, 3436212, Israel

  • Colorado Blood Cancer Institute ( Site 7000)

    RECRUITING

    Denver, Colorado, 80218, United States

  • Derriford Hospital ( Site 1304)

    RECRUITING

    Plymouth, Devon, Pl6 8DH, United Kingdom

  • Fondazione Policlinico Universitario Agostino Gemelli ( Site 0705)

    RECRUITING

    Roma, 00168, Italy

  • Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1000)

    RECRUITING

    Ankara, 06230, Turkey (Türkiye)

  • Haddasah Medical Center ( Site 0600)

    RECRUITING

    Jerusalem, 9112001, Israel

  • Hospital Universitari Vall de Hebron ( Site 1102)

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre ( Site 1105)

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Gregorio Maranon ( Site 1101)

    RECRUITING

    Madrid, 28007, Spain

  • Hospital Virgen de la Victoria ( Site 1104)

    RECRUITING

    Málaga, Malaga, 29010, Spain

  • INOC - Istituto Nazionale Oncologico Candiolo ( Site 0701)

    RECRUITING

    Candiolo, Piedmont, 10060, Italy

  • Institut Català d'Oncologia (ICO) - Badalona ( Site 1103)

    RECRUITING

    Badalona, Barcelona, 08916, Spain

  • Instituto Alexander Fleming ( Site 1404)

    RECRUITING

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

  • Istituto Europeo di Oncologia IRCCS ( Site 0702)

    RECRUITING

    Milan, 20141, Italy

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale-SC Ematologia Oncologica ( Site 0700)

    RECRUITING

    Campania, Napoli, 80131, Italy

  • Koç Üniversitesi Hastanesi ( Site 1001)

    RECRUITING

    Istanbul, 34010, Turkey (Türkiye)

  • Medipol Mega Universite Hastanesi ( Site 1002)

    RECRUITING

    Istanbul, 34214, Turkey (Türkiye)

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( Site 0900)

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • Pratia MCM Krakow ( Site 0903)

    RECRUITING

    Krakow, Lesser Poland Voivodeship, 30-727, Poland

  • Pratia Onkologia Katowice ( Site 0902)

    RECRUITING

    Katowice, Silesian Voivodeship, 40-519, Poland

  • Princess Margaret Cancer Centre ( Site 0301)

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

  • SCRI Oncology Partners ( Site 0100)

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Samsun Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi ( Site 1005)

    RECRUITING

    Samsun, 55270, Turkey (Türkiye)

  • Sanatorio Nuestra Senora del Rosario ( Site 1403)

    RECRUITING

    Rosario, Santa Fe Province, 2001, Argentina

  • Shaare Zedek Medical Center ( Site 0603)

    RECRUITING

    Jerusalem, 9103102, Israel

  • Sheba Medical Center ( Site 0601)

    RECRUITING

    Ramat Gan, 5265601, Israel

  • Sourasky Medical Center. ( Site 0604)

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Sun Yat-Sen University Cancer Center ( Site 1712)

    RECRUITING

    Guangzhou, Guangdong, 510060, China

  • The Catholic University of Korea, Yeouido St. Mary's Hospital ( Site 0801)

    RECRUITING

    Seoul, 07345, South Korea

  • The Christie NHS Foundation Trust ( Site 1300)

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • Townsville University Hospital ( Site 0204)

    RECRUITING

    Townsville, Queensland, 4814, Australia

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