New drug cocktail targets tough breast cancer
NCT ID NCT03901469
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a combination of two drugs, ZEN003694 and talazoparib, in people with triple-negative breast cancer who do not have BRCA gene mutations. The trial aimed to see if the combo could shrink tumors or stop them from growing. It included 115 participants but was terminated early, so final results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ZEN003694 (a BET inhibitor) combined with talazoparib (a PARP inhibitor)
- What this could lead to
- If successful, this combination could offer a new treatment option for triple-negative breast cancer patients who don't have BRCA mutations.
- What could go wrong
- The trial was terminated early, so results are limited. It was a phase 2 study, meaning it's still early and may not lead to a proven treatment. Side effects from the drug combination are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affliated Hospital of Jining Medical University
Jining, Shandong, 272000, China
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Emory University Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Hunan Cancer Hospital
Changsha, Hunan, 410000, China
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Institut Jules Bordet
Anderlecht, 1070, Belgium
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MD Anderson
Houston, Texas, 77030, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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START Madrid
Madrid, 28050, Spain
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Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510289, China
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Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, 510060, China
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Tennessee Oncology (Sarah Cannon)
Nashville, Tennessee, 37203, United States
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The First Affiliated Hosptial of Bengbu Medical College
Bengbu, Anhui, 233000, China
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The Second People's Hospital of Neijiang
Neijiang, Sichuan, 641100, China
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Tianjing Medical University Cancer Institute & Hospital
Tianjin, Tianjin Municipality, 300060, China
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UZ Leuven
Leuven, 3000, Belgium
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University of Kansas Cancer Center
Westwood, Kansas, 66203, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Vall d'Hebron Institute of Oncology (VHIO)
Barcelona, 08035, Spain
More trials for these conditions
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