New drug zanubrutinib takes on kidney disease in major trial

NCT ID NCT05707377

Ongoing Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the drug zanubrutinib can help people with primary membranous nephropathy, a kidney disease that causes protein leakage. About 178 participants will receive either zanubrutinib or the standard drug tacrolimus. The goal is to see if zanubrutinib reduces protein in urine and leads to complete remission of the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

zanubrutinib

What this could lead to

If successful, zanubrutinib could offer a new treatment option for people with this kidney disease, potentially reducing protein leakage and preserving kidney function.

What could go wrong

This is a mid-stage trial with 178 participants, so results are not yet proven. Zanubrutinib may not work better than the current drug, and side effects like infection or bleeding are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

idiopathic membranous glomerulonephritis membranous glomerulonephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY MEMBRANOUS NEPHROPATHY

Contacts and locations

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Locations

Aberdeen Royal Infirmary

Aberdeen, AB25 2ZN, United Kingdom
Amicis Research Center

Granada Hills, California, 91344, United States
Beijing An Zhen Hospital, Capital Medical University

Beijing, Beijing Municipality, 100029, China
Carolina Nephrology

Spartanburg, South Carolina, 29306-3927, United States
Erciyes University Medical Faculty

Erciyes, 38030, Turkey (Türkiye)
Fakultni Nemocnice Olomouc

Olomouc, 77900, Czechia
Fujian Medical University Union Hospital

Fuzhou, Fujian, 350001, China
General Hospital of Ningxia Medical University

Yinchuan, Ningxia, 750004, China
Guangdong Provincial Peoples Hospital

Guangzhou, Guangdong, 510080, China
Guizhou Provincial Peoples Hospital

Guiyang, Guizhou, 550002, China
Hcfmusp Hospital Das Clinicas Da Faculdade de Medicina Da Universidade de Sao Paulo

São Paulo, 05403-000, Brazil
Instituto Pro Renal Brasil

Curitiba, 80420-011, Brazil
Intermed Consultants

Minneapolis, Minnesota, 55435-2130, United States
Istscientifico Di Pavia, Fondazione Smaugeri, Irccs, Clinica Del Lavoro E Della Riabilitazione

Pavia, 27100, Italy
Jiangsu Province Hospital

Nanjing, Jiangsu, 210029, China
Kidney Specialist of Southern Nevada (Ksosn)

Las Vegas, Nevada, 89106-4852, United States
Kocaeli University Research and Application Hospital Department of Nephrology

Kocaeli, 41380, Turkey (Türkiye)
Medical Company Llc

Grozny, Chechenskaya Respublika, 364029, Russia
Nanyang Central Hospital

Nanyang, Henan, 473000, China
Ott Healthcare, Inc (Corporate Medical Centre)

Scarborough Village, Ontario, M1H 3G4, Canada
Peking University First Hospital

Beijing, Beijing Municipality, 100034, China
Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518036, China
Renmin Hospital of Wuhan University

Wuhan, Hubei, 430060, China
Royal Derby Hospital

Derby, DE22 3NE, United Kingdom
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200025, China
Shandong Provincial Hospital

Jinan, Shandong, 250021, China
Shanghai General Hospital

Shanghai, Shanghai Municipality, 200080, China
Shanxi Provincial Peoples Hospital

Taiyuan, Shanxi, 030012, China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital

Chengdu, Sichuan, 610071, China
Stanford University

Palo Alto, California, 94304, United States
The Affiliated Hospital of Qingdao University Branch South

Qingdao, Shandong, 266000, China
The First Affiliated Hospital of Baotou Medical College

Baotou, Inner Mongolia, 14017, China
The First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, 530021, China
The First Affiliated Hospital of Ningbo University

Ningbo, Zhejiang, 315010, China
The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, 361003, China
The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, 830054, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital, Sun Yat Sen University

Guangzhou, Guangdong, 510080, China
The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310003, China
The First Hospital of Hebei Medical University

Shijiazhuang, Hebei, 50000, China
The Second Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150001, China
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China
University of Cincinnati College of Medicine

Cincinnati, Ohio, 45267-2827, United States
Vseobecna Fakultni Nemocnice V Praze

Prague, 10000, Czechia
Weifang Peoples Hospital

Weifang, Shandong, 261000, China
Wuxi Peoples Hospital

Wuxi, Jiangsu, 214023, China
Zhejiang Provincial Peoples Hospital

Hangzhou, Zhejiang, 310014, China