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Can your own tooth be the best bone graft? a trial puts it to the test

NCT ID NCT07723183

Disease control Sponsor: University of Malaya Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This trial tests whether a bone graft made from a patient's own extracted wisdom tooth works as well as a synthetic material (EthOss) for preserving bone and gum after lower wisdom tooth removal. In a split-mouth design, each participant receives both grafts—one in each socket—and is followed for 24 weeks. Researchers measure pain, swelling, gum healing, and new bone growth to see which material performs better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
auto tooth bone graft (ATB) or synthetic EthOss
What this could lead to
If successful, this could show that using a patient's own tooth as a graft is a safe and effective option for preserving bone and gum after wisdom tooth removal.
What could go wrong
This is a small, early-phase trial with only 12 participants, so results may not apply to everyone. Both grafts are already used clinically, so the main question is about comparative performance, not a breakthrough.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

12 people

The number who actually took part.

Started

Aug 2023

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient who requires surgical removal of bilateral impacted M3. * Patient with impacted bilateral M3 which are sound. * Impacted bilateral M3 classified as Class I or II with Level A or B according to Pell and Gregory's classification. * Presence of M2 adjacent to the M3 to be extracted. * Patient aged 18 to 35 years old. * Patient with periodontal status of: * Basic Periodontal Score (BPE) 2 at lower right and lower left sextants. * Full mouth plaque score \<30%. Exclusion Criteria: * Impacted M3 associated in the following conditions: * Fracture of angle of mandible. * Radiological evidence of cyst or tumour. * Incomplete root formation. * Acute pulpitis or severe pericoronitis that is not under-controlled. * Gross dental caries. * Retained roots of mandibular third molar with history of removal of unerupted/impacted M3. * Patient's age \<18 years old or \> 35 years old * M2 with periapical inflammation, periodontitis, distal caries or delayed or non-responsive pulp sensibility test to exclude tooth with perio-endo lesion. * Pregnant woman. * Patient on oral contraceptives. * Current or previous bisphosphonate therapy or history of radiotherapy to the jaws. * Active smoker.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Socket preservation Wisdom tooth Wisdom tooth socket preservation

Contacts and locations

Locations

  • Faculty of Dentistry Universiti Malaya

    Kuala Lumpur, Wilayah Perseketuan Kuala Lumpur, 50603, Malaysia

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